A multicenter, outpatient, open-label study to evaluate the dosing, effectiveness, and safety of topiramate as monotherapy in the treatment of epilepsy in clinical practice

Epilepsy and Behavior

Volumn 15, Issue 4, 2009, Pages 506-512

  Sankar, Raman ^a   Ramsay, Eugene ^b   McKay, Amy ^c   Hulihan, Joseph ^c   Wiegand, Frank ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Epilepsy; Monotherapy; Partial onset seizures; Primary generalized tonic clonic seizures; Stabilized dose; Tolerability; Topiramate

Indexed keywords

CARBAMAZEPINE; CLONAZEPAM; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; LORAZEPAM; OXCARBAZEPINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ADOLESCENT; ADULT; AGED; ANOREXIA; ARTICLE; ATTENTION DISTURBANCE; BICARBONATE BLOOD LEVEL; CHILD; CHLORIDE BLOOD LEVEL; CLINICAL PRACTICE; CLINICAL TRIAL; CONCENTRATION LOSS; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPILEPSY; EVENING DOSAGE; FATIGUE; FEMALE; HUMAN; HYPESTHESIA; INSOMNIA; LIVER FUNCTION TEST; MAGNESIUM BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MONOTHERAPY; MOOD DISORDER; MORNING DOSAGE; MULTICENTER STUDY; NAUSEA; OPEN STUDY; OUTPATIENT; PARESTHESIA; PSYCHOMOTOR DISORDER; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOMNOLENCE; SPEECH DISORDER; TASTE AVERSION; WEIGHT REDUCTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; CHILD; DATA INTERPRETATION, STATISTICAL; EPILEPSY; FEMALE; FRUCTOSE; HUMANS; MALE; MIDDLE AGED; OUTPATIENTS; SEIZURES; YOUNG ADULT;

EID: 67849118449     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2009.06.021     Document Type: Article

References (23)

1. WHO. Epilepsy, ; 2007 [accessed September 2007].
2. Epilepsy Foundation. Epilepsy and seizure statistics, ; 2007 [accessed September 2007].
3. WHO. Epilepsy: Aetiology, epidemiology, and prognosis, ; 2007 [accessed September 2007].
4. Gilliam F. Optimizing health outcomes in active epilepsy. Neurology 58 Suppl. 5 (2002) S9-S20
5. Kwan P., and Brodie M.J. Effectiveness of first antiepileptic drug. Epilepsia 10 (2001) 1255-1260
6. Elger C.E., Brodie M.J., Anhut H., et al. Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study. Epilepsia 46 (2005) 1926-1936
7. French J.A., Kanner A.M., Bautista J., et al. Efficacy and tolerability of the new antiepileptic drugs: I. Treatment of new onset epilepsy. Neurology 62 (2004) 1252-1260
8. Arroyo S., Dodson W.E., Privitera M.D., et al. For the EPMN-106/INT-28 Investigators. Randomized dose-controlled study of topiramate as first-line therapy in epilepsy. Acta Neurol Scand 112 (2005) 214-222
9. Gilliam F.G., Veloso F., Bomhof M.A.M., et al. A dose-comparison trial of topiramate as monotherapy in recently diagnosed partial epilepsy. Neurology 60 (2003) 196-202
10. Privitera M.D., Brodie M.J., Mattson R.H., Chadwick D.W., Neto W., Wang S., and for the EPMN 105 Study Group. Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. Acta Neurol Scand 107 (2003) 165-175
11. Ramsay E.R., Uthman B., Pryor F.M., et al. Topiramate in older patients with partial-onset seizures: a pilot double-blind, dose-comparison study. Epilepsia 49 (2008) 1180-1185
12. Glauser T., Ben-Menachem E., Bourgeois B., et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 47 (2006) 1094-1120
13. MacDonald B.K., et al. Factors predicting prognosis of epilepsy after presentation with seizures. Ann Neurol 48 (2000) 833-841
14. Sillanpää M. Remission of seizures and predictors of intractability in long-term follow-up. Epilepsia 34 (1993) 930-936
15. Collaborative Group for the Study of Epilepsy. Prognosis of epilepsy in newly referred patients: a multicenter prospective study of the effects of monotherapy on the long-term course of epilepsy. Epilepsia 1992;33:45-51.
16. Kwan P., and Brodie M. Early identification of refractory epilepsy. N Engl J Med 342 (2000) 314-319
17. Reynolds E.H. Early treatment and prognosis of epilepsy. Epilepsia 28 (1987) 97-106
18. Reynolds E.H. Controversies in management: do anticonvulsants alter the natural course of epilepsy? Treatment should be started as early as possible. Br Med J 310 (1995) 176-177
19. Reynolds E.H., Elwes R.D., and Shorvon S.D. Why does epilepsy become intractable? Prevention of chronic epilepsy. Lancet 332 (1983) 952-954
20. Berg A.T., and Shinnar S. Do seizures beget seizures? An assessment of the clinical evidence in humans. J Clin Neurophysiol 14 (1997) 102-110
21. Von Donselaar C.A., Brouwer O.F., Geerts A.T., et al. Clinical course of untreated tonic-clonic seizures in childhood: prospective, hospital based study. Br Med J 314 (1997) 401-404
22. Jones R.M., Butler J.A., Thomas V.A., et al. Adherence to treatment in patients with epilepsy: associations with seizure control and illness beliefs. Seizure 15 (2006) 504-508
23. Enriquez-Caceres M., and Soto-Santillana M. Non-compliance with pharmacological treatment in patients with epilepsy. Rev Neurol 42 (2006) 647-654