Beta human chorionic gonadotropin (β-hCG) expression in pituitary adenomas: Relationship to endocrine function and tumour recurrence

Pituitary

Volumn 12, Issue 3, 2009, Pages 190-195

  Doyle, Paul M ^a   Thiryayi, Waziq A ^a   Joshi, Abhijit ^a   du Plessis, Daniel ^a   Kearney, Tara ^a   Gnanalingham, Kanna K ^a  

^a HOPE HOSPITAL   (United Kingdom)

Author keywords

Beta human chorionic gonadotropin ( hCG); Endocrine function and tumour recurrence; Pituitary adenomas

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; CORTICOTROPIN; GROWTH HORMONE; KI 67 ANTIGEN; PROLACTIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RECURRENCE; ENDOCRINE FUNCTION; FEMALE; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NONFUNCTIONING PITUITARY ADENOMA; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECURRENCE RISK;

ADULT; AGED; AGED, 80 AND OVER; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PITUITARY NEOPLASMS;

EID: 67849111433     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11102-008-0155-x     Document Type: Article

References (27)

1. Heaney AP (2005) Pituitary tumour pathogenesis. Br Med Bull 75-76:81-97
2. Horvath E (1994) Ultrastructural markers in the pathological diagnosis of pituitary adenomas. Ultrastruct Pathol 18:171-179
3. Kovacs K, Horvath E (1986) Tumours of the pituitary gland. In: Hartmann WH, Sabin LH (eds) Atlas of tumour pathology. Armed Forces Institute of Pathology, Washington, pp 47-49
4. Jameson JL, Klibanski A, Black PM, Zervas NT, Lindell CM, Hsu DW et al (1987) Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest 80(5):1472-1478
5. Baz E, Saeger W, Uhlig H, Fehr S, Ludecke DK (1991) HGH, PRL and beta HCG/beta LH gene expression in clinically inactive pituitary adenomas detected by in situ hybridization. Virchows Arch A Pathol Anat Histopathol 418:405-410
6. Dirnhofer S, Hermann M, Hittmair A, Hoermann R, Kapelari K, Berger P (1996) Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1. J Clin Endocrinol Metab 81(12):4212-4217
7. Levy A, Biswas S, Burton PA, Lightman SL (1994) Expression of chorionic gonadotrophin in human pituitary adenomas. Eur J Endocrinol 131(6):615-622
8. Black PM, Hsu DW, Klibanski A, Kliman B, Jameson JL, Ridgway EC et al (1987) Hormone production in clinically nonfunctioning pituitary adenomas. J Neurosurg 66(2):244-250
9. Cole LA (1998) HCG, its free subunits and its metabolites: Roles in pregnancy and trophoblastic disease. J Reprod Med 43:3-10
10. Syrigos KN, Fyssas I, Konstandoulakis MM, Harrington KJ, Papadopoulos S, Milingos N et al (1998) Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma. Gut 42(1):88-91
11. Yoong W, Subba B, Youssef I, Ojo K, Jarvis K (2005) Pancreatic adenocarcinoma: A cause of elevated serum beta HCG. J Obstet Gynaecol 25(1):89-91
12. Stenman UH, Alfthan H, Ranta T, Vartiainen E, Jalkanen J, Seppala M (1987) Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin-releasing hormone and sex steroids. J Clin Endocrinol Metab 64(4):730-736
13. Policastro PF, Daniels-McQueen S, Carle G, Boime I (1986) A map of the hCG beta-LH beta gene cluster. J Biol Chem 261(13):5907-5916
14. Hollenberg AN, Pestell RG, Albanese C, Boers ME, Jameson JL (1994) Multiple promoter elements in the human chorionic gonadotropin beta subunit genes distinguish their expression from the luteinizing hormone beta gene. Mol Cell Endocrinol 106(1-2):111-119
15. Pizarro CB, Oliveira MC, Coutinho LB, Ferreira NP (2004) Measurement of Ki-67 antigen in 159 pituitary adenomas using the MIB-1 monoclonal antibody. Braz J Med Biol Res 37(2):235-243
16. Saccomanno K, Spada A, Bassetti M, Gil-del-Alamo P, Faglia G (1994) Immunodetection of chorionic gonadotropin and its subunits in human nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 78(5):1103-1107
17. Filippella M, Galland F, Kujas M, Young J, Faggiano A, Lombardi G et al (2006) Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: A clinical and immunohistochemical study. Clin Endocrinol (Oxf) 65(4):536-543
18. Mastronardi L, Guiducci A, Spera C, Puzzilli F, Liberati F, Maira G (1999) Ki-67 labelling index and invasiveness among anterior pituitary adenomas: Analysis of 103 cases using the MIB-1 monoclonal antibody. J Clin Pathol 52(2):107-111
19. Saccomanno K, Bassetti M, Lania A, Losa M, Faglia G, Spada A (1997) Immunodetection of glycoprotein hormone subunits in nonfunctioning and glycoprotein hormone-secreting pituitary adenomas. J Endocrinol Invest 20(2):59-64
20. Hammond E, Griffin J, Odell WD (1991) A chorionic gonadotropin-secreting human pituitary cell. J Clin Endocrinol Metab 72(4):747-754
21. Berger P, Kranewitter W, Madersbacher S, Gerth R, Geley S, Dirnhofer S (1994) Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis. FEBS Lett 343:229-233
22. Lei ZM, Toth P, Rao CV, Pridham D (1993) Novel coexpression of human chorionic gonadotropin (hCG)/human luteinizing hormone receptors and their ligand hCG in human fallopian tubes. J Clin Endocrinol Metab 77(3):863-872
23. Tallen G, Fehr S, Saeger W, Uhlig H, Lüdecke DK (1993) Detection of growth hormone, prolactin and human beta-chorionic gonadotropin mRNA in growth hormone-secreting pituitary adenomas and in prolactin-secreting pituitary adenomas by in situ hybridization using a non-isotopic detection method. Acta Endocrinol (Copenh) 128(5):411-417
24. Mahta A, Haghpanah V, Lashkari A, Heshmat R, Larijani B, Tavangar SM (2007) Nonfunctioning pituitary adenoma: Immunohistochemical analysis of 85 cases. Folia Neuropathol 45(2):72-77
25. Ruddon RW, Krzesicki RF, Beebe JS, Loesel L, Perini F, Peters BP (1989) Conformational intermediates in the production of the combinable form of the beta-subunit of chorionic gonadotropin. Endocrinology 124(2):862-869
26. Thapar K, Kovacs K, Scheithauer BW, Stefaneanu L, Horvath E, Pernicone PJ et al (1996) Proliferative activity and invasiveness among pituitary adenomas and carcinomas: An analysis using the MIB-1 antibody. Neurosurgery 38(1):99-106
27. Hsu DW, Hakim F, Biller BMK, de la Monte S, Zervas NT, Klibanski et al (1993) Significance of proliferation of cell nuclear antigen index in predicting pituitary adenoma recurrence. J Neurosurg 78:753-761