Immunodetection of glycoprotein hormone subunits in nonfunctioning and glycoprotein hormone-secreting pituitary adenomas

Journal of Endocrinological Investigation

Volumn 20, Issue 2, 1997, Pages 59-64

  Saccomanno, K ^a   Bassetti, M ^b   Lania, A ^a   Losa, M ^b   Faglia, G ^a   Spada, A ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Glycoprotein; Immunohistochemistry; Pituitary adenomas; Pituitary tumors

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; GLYCOPROTEIN; GONADOTROPIN; LUTEINIZING HORMONE; PEPTIDE HORMONE; PROTEIN SUBUNIT; THYROTROPIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; PROTEIN EXPRESSION; SCHOOL CHILD;

EID: 0030899274     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03347977     Document Type: Article

References (22)

1. Asa S.L., Gerrie B.M., Singer W., Horvath E., Kovaks K., Smyth H.S. Gonadotropin secretion in vitro by human pituitary null cell adenomas and oncocytomas. J. Clin. Endocrinol. Metab. 62: 1011, 1986.
2. Jameson J.L.,Klibansky A.,Black P.M.,Zervas N.T.,Lindell C.M., Husu DW, Snyder P.J. Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J. Clin. Endocrinol. Metab. 80: 1472, 1987.
3. Yamada S., Asa S.L., Kovaks K., Muller P., Smyth H.S. Analysis of hormone secretion by clinically nonfunctioning human pituitary adenomas using the reverse hemolytic plaque assay. J. Clin. Endocrinol. Metab. 68: 73, 1989.
4. Kwekkeboom D.J., De Jong F.H., Lamberts S.W.J. Gonadotropin release by clinically nonfunctioning and gonadotroph pituitary adenomas in vivo and in vitro; relation to sex and effects of thytropin-releasing hormone, gonadotropin-releasing hormone and bromocriptine. J. Clin. Endocrinol. Metab. 68: 1128, 1989.
5. Beck-Peccoz P., Persani L., Medri G., Guerrero M.I., Spada A., Faglia G. New aspect in "non-functioning" pituitary tumors. In: Casanueva F.F., Dieguez C., (Eds.) Recent advances in basic and clinical neuroendocrinology. Elvesier, Amsterdam, 1989, p. 295.
6. Katznelson L., Alexander J.M., Bikkal H.A., Jameson J.L., Husu D.W., Klibanski A. Imbalanced follicle-stimulating hormone β-subunit hormone biosynthesis in human pituitary adenomas. J. Clin. Endocrinol. Metab. 74: 1343, 1992.
7. Saccomanno K., Gil-del-Alamo P., Bassetti M., Reza-Elahi F., Spada A. In vitro detection of glycoprotein production and secretion by human nonfunctioning pituitary adenomas. J. Endocrinol. Invest. 16: 105, 1993.
8. Heshmati H.M., Turpin G., Kujas M. The immunocytochemical heterogeneity of silent pituitary adenomas. Acta Endocrinol. (Copenh.) 118: 533, 1988.
9. Saccomanno K., Spada A., Bassetti M., Gil-del-Alamo P., Faglia G. Immunodetection of chorionic gonadotropin and its subunits in human nonfunctioning pituitary adenomas. J. Clin. Endocrinol. Metab. 78: 1103, 1994.
10. Ambrosi B., Bassetti M., Ferrario R., Medri G., Giannattasio G., Faglia G. Precocious puberty in a boy with a PRL-, LH-, and FSH-secreting pituitary tumor; hormonal and immunocytochemical sudies. Acta Endocrinol. (Copenh.) 122: 569, 1990.
11. Bassetti M., Spada A., Arosio M., Valklr L., Brina M., Giannattasio G. Morphological studies on mixed growth hormone (GH) and prolactin (PRL)-secreting human pituitary adenomas. Coexistence of GH and PRL in the same secretory granule. J. Clin. Endocrinol. Metab. 62: 1093, 1986.
12. Bassetti M., Brina M., Spada A., Giannattasio G. Somatomammotrophic cells in GH-secreting and PRL-secreting human pituitary adenomas. J. Endocrinol. Invest. 12: 705, 1989.
13. Rosa P., Bassetti M., Weiss U., Huttner W.B. Widespread occurrence of secretogranin/cromogranin in the matrix of secretory granules of endocrinologically silent pituitary adenomas. J. Histochem. Cytochem. 40: 523, 1992.
14. Gil-Del-Alamo P., Saccomanno K., Lania A., Pettersson K.S.I., Beck-Peccoz P., Spada A. Serum levels of β-subunit of chorionic gonadotropin in patients with pituitary tumors. Eur. J. Endocrinol. 133: 33, 1985.
15. Beck-Peccoz P., Persani L., Faglia G. Glycoprotein hormone α-subunit in pituitary adenomas. Trends Endocrinol. Metab. 3: 41, 1992.
16. Snyder P.J. Gonadotroph cell adenomas of the pituitary. Endocr. Rev. 6: 552, 1985.
17. Daneshdoost L., Genarelli T.A., Bashey H.M., Savino P.J., Sergott R.C., Bosley T.M., Snyder P.J. Recognition of gonadotroph adenomas in women. N. Engl. J. Med. 324: 589, 1991.
18. Daneshdoost L., Genarelli T.A., Bashey H.M., Savino P.J., Sergott R.C., Bosley T.M., Snyder P.J. Identification of gonadotroph adenomas in men with clinically nonfunctioning adenomas by the luteinizing hormone β subunit response to thyrotropin -releasing hormone. J. Clin. Endocrinol. Metab. 77: 1352, 1993.
19. Snyder P.J. Gonadotroph adenomas. J. Clin. Endocrinol. Metab. 80: 1059, 1995.
20. Gil-del-Alamo P., Pettersson K.S.I., Saccomanno K., Spada A., Faglia G., Beck-Peccoz P. Abnormal response of luteinizing hormone beta subunit to thyrotropin-releasing hormone in patients with nonfunctioning pituitary adenomas. Clin. Endocrinol. (Oxf.) 41: 661, 1994.
21. Alexander J.M., Biller B.M.K., Bikkai H., Zervas N.T., Arnold A., Klibanski A. A Clinically nonfunctioning pituitary tumors are monoclonal in origin. J. Clin. Invest. 86: 336, 1990.
22. Kopp P., Kimura E.T., Aeschimann S., Oestreicher M., Tobler A., Studer H. Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters. J. Clin. Endocrinol. Metab. 79: 134, 1994.