메뉴 건너뛰기




Volumn 18, Issue 4, 2009, Pages 303-307

Adynamic bone disease: clinical and therapeutic implications

Author keywords

Adynamic bone disease; chronic kidney disease; hemodialysis; vascular calcification

Indexed keywords

ALKALINE PHOSPHATASE; ALUMINUM HYDROXIDE; BIOLOGICAL MARKER; CALCIUM; CALCIUM CARBONATE; LANTHANUM CARBONATE; PARATHYROID HORMONE; SEVELAMER; VITAMIN D;

EID: 67849096870     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32832c4df0     Document Type: Review
Times cited : (47)

References (39)
  • 1
    • 0031920748 scopus 로고    scopus 로고
    • Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study
    • Block G, Hulbert-Shearon T, Levin N, et al. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 1998; 31:607-617.
    • (1998) Am J Kidney Dis , vol.31 , pp. 607-617
    • Block, G.1    Hulbert-Shearon, T.2    Levin, N.3
  • 2
    • 3543139492 scopus 로고    scopus 로고
    • Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    • Block GA, Klassen PS, Lazarus JM, et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15:2208-2218.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2208-2218
    • Block, G.A.1    Klassen, P.S.2    Lazarus, J.M.3
  • 3
    • 0035725506 scopus 로고    scopus 로고
    • Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    • Blacher J, Gué rin AP, Pannier B, et al. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 2001; 38:938-942.
    • (2001) Hypertension , vol.38 , pp. 938-942
    • Blacher, J.1    Gué rin, A.P.2    Pannier, B.3
  • 4
    • 33645757920 scopus 로고    scopus 로고
    • Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    • Moe S, Drueke T, Cunningham J, et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69:1945-1953.
    • (2006) Kidney Int , vol.69 , pp. 1945-1953
    • Moe, S.1    Drueke, T.2    Cunningham, J.3
  • 5
    • 0001844737 scopus 로고
    • Uremic osteodystrophy, classification, cause, and treatment
    • Frame B, Potts JRJ, editors, Amesterdam: Excerpta Medica;
    • Sherrard DJ, Out S, Maloney NA. Uremic osteodystrophy, classification, cause, and treatment. In: Frame B, Potts JRJ, editors. Clinical disorders of bone and mineral metabolism. Amesterdam: Excerpta Medica; 1983. pp. 254-259.
    • (1983) Clinical disorders of bone and mineral metabolism , pp. 254-259
    • Sherrard, D.J.1    Out, S.2    Maloney, N.A.3
  • 7
    • 12544257882 scopus 로고    scopus 로고
    • Bone biopsy as a diagnostic tool in the assessment of renal osteosdystrophy
    • Spasovski GB. Bone biopsy as a diagnostic tool in the assessment of renal osteosdystrophy. Int J Artif Organs 2004; 27:918-923.
    • (2004) Int J Artif Organs , vol.27 , pp. 918-923
    • Spasovski, G.B.1
  • 8
    • 0031714473 scopus 로고    scopus 로고
    • Hypokinetic azotemic osteodystrophy
    • Cannata-Andia JB. Hypokinetic azotemic osteodystrophy. Kidney Int 1998; 54:1000-1016.
    • (1998) Kidney Int , vol.54 , pp. 1000-1016
    • Cannata-Andia, J.B.1
  • 9
    • 44449113188 scopus 로고    scopus 로고
    • Adynamic bone disease: Bone and beyond
    • This is an excellent and very comprehensive review of adynamic bone disease
    • Brandenburg VM, Floege J. Adynamic bone disease: bone and beyond. NDT Plus 2008; 3:135-147. This is an excellent and very comprehensive review of adynamic bone disease.
    • (2008) NDT Plus , vol.3 , pp. 135-147
    • Brandenburg, V.M.1    Floege, J.2
  • 10
    • 0022566861 scopus 로고
    • Aluminum and renal osteodystrophy
    • Nebeker HG, Coburn JW. Aluminum and renal osteodystrophy. Annu Rev Med 1986; 37:79-95.
    • (1986) Annu Rev Med , vol.37 , pp. 79-95
    • Nebeker, H.G.1    Coburn, J.W.2
  • 12
    • 85120122088 scopus 로고    scopus 로고
    • Barreto FC, Barreto DV, Moyses RM, et al. K/DOQI-recommended intact PTH levels do not prevent low-turnover bone disease in hemodialysis patients. Kidney Int 2008; 73:771-777. This interesting study tested the effectiveness of the K/DOQI-suggested iPTH target range indialysispatients with CKD stage 5 forpreventing bone-remodeling disorders in hemodialysis patients. The bone biopsies from patients with iPTH levels within the recommended K/DOQI guidelines range showed a high incidence of low-turnover bone disease. The data suggest that other biochemical markers may be required to accurately measure bone-remodeling status in hemodialysis patients.
    • Barreto FC, Barreto DV, Moyses RM, et al. K/DOQI-recommended intact PTH levels do not prevent low-turnover bone disease in hemodialysis patients. Kidney Int 2008; 73:771-777. This interesting study tested the effectiveness of the K/DOQI-suggested iPTH target range indialysispatients with CKD stage 5 forpreventing bone-remodeling disorders in hemodialysis patients. The bone biopsies from patients with iPTH levels within the recommended K/DOQI guidelines range showed a high incidence of low-turnover bone disease. The data suggest that other biochemical markers may be required to accurately measure bone-remodeling status in hemodialysis patients.
  • 13
    • 1842575839 scopus 로고    scopus 로고
    • The importance of bone health in end-stage renal disease: Out of the frying pan, into the fire?
    • Malluche HH, Mawad H, Monier-Faugere MC. The importance of bone health in end-stage renal disease: out of the frying pan, into the fire? Nephrol Dial Transplant 2004; 19 (Suppl 1):i9-i13.
    • (2004) Nephrol Dial Transplant , vol.19 , Issue.SUPPL. 1
    • Malluche, H.H.1    Mawad, H.2    Monier-Faugere, M.C.3
  • 14
    • 0037670176 scopus 로고    scopus 로고
    • Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis
    • Spasovski GB, Bervoets AR, Behets GJ, et al. Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis. Nephrol Dial Transplant 2003; 18:1159-1166.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 1159-1166
    • Spasovski, G.B.1    Bervoets, A.R.2    Behets, G.J.3
  • 15
    • 85190652692 scopus 로고    scopus 로고
    • Ferreira A, Frazão JM, Monier-Faugere MC, et al. Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients. J Am Soc Nephrol 2008; 19:405-412. This randomized, open-label study, conducted in 119 hemodialysis patients over 54 weeks compared the effects of sevelamer hydrochloride and calcium carbonate on bone. Biopsy-proven adynamic bone disease was the most frequent bone abnormality at baseline (59%). Sevelamer resulted in no statistically significant changes in bone turnover or mineralization compared with calcium carbonate, but the bone formation rate increased and trabecular architecture improved with sevelamer treatment.
    • Ferreira A, Frazão JM, Monier-Faugere MC, et al. Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients. J Am Soc Nephrol 2008; 19:405-412. This randomized, open-label study, conducted in 119 hemodialysis patients over 54 weeks compared the effects of sevelamer hydrochloride and calcium carbonate on bone. Biopsy-proven adynamic bone disease was the most frequent bone abnormality at baseline (59%). Sevelamer resulted in no statistically significant changes in bone turnover or mineralization compared with calcium carbonate, but the bone formation rate increased and trabecular architecture improved with sevelamer treatment.
  • 17
    • 33846446044 scopus 로고    scopus 로고
    • Comments on plasma parathyroid hormone levels and their relationship to bone histopathology among patients undergoing dialysis
    • Goodman WG. Comments on plasma parathyroid hormone levels and their relationship to bone histopathology among patients undergoing dialysis. Semin Dial 2007; 20:1-4.
    • (2007) Semin Dial , vol.20 , pp. 1-4
    • Goodman, W.G.1
  • 18
    • 23844542415 scopus 로고    scopus 로고
    • The evolution of assays for parathyroid hormone
    • Goodman WG. The evolution of assays for parathyroid hormone. Semin Dial 2005; 18:296-301.
    • (2005) Semin Dial , vol.18 , pp. 296-301
    • Goodman, W.G.1
  • 19
    • 0034791485 scopus 로고    scopus 로고
    • Improved assessment of bone turnover by PTH-(1-84)/large C-PTH fragments ratio in ESRD patients
    • Monier-Faugere MC, Geng Z, Mawad H, et al. Improved assessment of bone turnover by PTH-(1-84)/large C-PTH fragments ratio in ESRD patients. Kidney Int 2001; 60:1460-1468.
    • (2001) Kidney Int , vol.60 , pp. 1460-1468
    • Monier-Faugere, M.C.1    Geng, Z.2    Mawad, H.3
  • 20
    • 0036189082 scopus 로고    scopus 로고
    • Osteoprotegerin and parathyroid hormone as markers of high-turnover osteodystrophy and decreased bone mineralization in hemodialysis patients
    • Haas M, Leko-Mohr Z, Roschger P, et al. Osteoprotegerin and parathyroid hormone as markers of high-turnover osteodystrophy and decreased bone mineralization in hemodialysis patients. Am J Kidney Dis 2002; 39:580-586.
    • (2002) Am J Kidney Dis , vol.39 , pp. 580-586
    • Haas, M.1    Leko-Mohr, Z.2    Roschger, P.3
  • 21
    • 0033021783 scopus 로고    scopus 로고
    • Circulating biochemical markers of bone remodelling in uremic patients
    • Urena P, De Vernejoul MC. Circulating biochemical markers of bone remodelling in uremic patients. Kidney Int 1999; 55:2141-2156.
    • (1999) Kidney Int , vol.55 , pp. 2141-2156
    • Urena, P.1    De Vernejoul, M.C.2
  • 22
    • 3042528668 scopus 로고    scopus 로고
    • Arterial calcifications and bone histomorphometry in end-stage renal disease
    • London GM, Marty C, Marchais SJ, et al. Arterial calcifications and bone histomorphometry in end-stage renal disease. J Am Soc Nephrol 2004; 15:1943-1951.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1943-1951
    • London, G.M.1    Marty, C.2    Marchais, S.J.3
  • 23
    • 29244440848 scopus 로고    scopus 로고
    • PTH and the risks for hip, vertebral, and pelvic fractures among patients on dialysis
    • Danese MD, Kim J, Doan QV, et al. PTH and the risks for hip, vertebral, and pelvic fractures among patients on dialysis. Am J Kidney Dis 2006; 47:149-156.
    • (2006) Am J Kidney Dis , vol.47 , pp. 149-156
    • Danese, M.D.1    Kim, J.2    Doan, Q.V.3
  • 24
    • 0042885985 scopus 로고    scopus 로고
    • Arterial media calcification in end-stage renal disease: Impact on all-cause and cardiovascular mortality
    • London GM, Gué rin AP, Marchais SJ, et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephol Dial Transplant 2003; 18:1731-1740.
    • (2003) Nephol Dial Transplant , vol.18 , pp. 1731-1740
    • London, G.M.1    Gué rin, A.P.2    Marchais, S.J.3
  • 25
    • 2942724370 scopus 로고    scopus 로고
    • A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients
    • Adragão T, Pires A, Lucas C, et al. A simple vascular calcification score predicts cardiovascular risk in haemodialysis patients. Nephrol Dial Transplant 2004; 19:1480-1488.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 1480-1488
    • Adragão, T.1    Pires, A.2    Lucas, C.3
  • 26
    • 0037138580 scopus 로고    scopus 로고
    • Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease?
    • Raggi P, Boulay A, Chasan-Taber S, et al. Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 2002; 39:695-701.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 695-701
    • Raggi, P.1    Boulay, A.2    Chasan-Taber, S.3
  • 27
    • 0027991769 scopus 로고
    • Evidence for abnormal calcium homeostasis in patients with adynamic bone disease
    • Kurz P, Monier-Faugere MC, Bognar B, et al. Evidence for abnormal calcium homeostasis in patients with adynamic bone disease. Kidney Int 1994; 46:855-861.
    • (1994) Kidney Int , vol.46 , pp. 855-861
    • Kurz, P.1    Monier-Faugere, M.C.2    Bognar, B.3
  • 28
    • 44449085692 scopus 로고    scopus 로고
    • The link between cardiovascular and bone disease in hemodialysis patients
    • vi 217 MO014
    • Asci G, Ozkahya M, Duman S, et al. The link between cardiovascular and bone disease in hemodialysis patients. Nephrol Dial Transplant 2007; 22(Suppl 6): vi 217 (MO014).
    • (2007) Nephrol Dial Transplant , vol.22 , Issue.SUPPL. 6
    • Asci, G.1    Ozkahya, M.2    Duman, S.3
  • 29
    • 54749090958 scopus 로고    scopus 로고
    • London GM, Marchais SJ, Gé rin AP, et al. Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD. J Am Soc Nephrol 2008; 19:1827-1835. Using bone histomorphometry and pulse wave velocity in 66 dialysis patients, there was a positive relationship between calcium load, bone activity and aortic stiffness. These positive associations were stronger in patients with adynamic bone disease.
    • London GM, Marchais SJ, Gé rin AP, et al. Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD. J Am Soc Nephrol 2008; 19:1827-1835. Using bone histomorphometry and pulse wave velocity in 66 dialysis patients, there was a positive relationship between calcium load, bone activity and aortic stiffness. These positive associations were stronger in patients with adynamic bone disease.
  • 30
    • 56049127121 scopus 로고    scopus 로고
    • Barreto DV, Barreto FC, Carvalho AB, et al. Association of changes in bone remodeling and coronary calcification in hemodialysis patients: a prospective study. Am J Kidney Dis 2008; 52:1139-1150. This prospective study evaluated the association between bone remodeling disorders and progression of coronary artery calcification in 64 hemodialysis patients. Bone-related laboratory parameters and bone histomorphometric characteristics were assessed at baseline and after 1 year of follow-up. Low-turnover bone disease correlated with coronary artery calcification scores assessed by coronary multislice tomography and its progression.
    • Barreto DV, Barreto FC, Carvalho AB, et al. Association of changes in bone remodeling and coronary calcification in hemodialysis patients: a prospective study. Am J Kidney Dis 2008; 52:1139-1150. This prospective study evaluated the association between bone remodeling disorders and progression of coronary artery calcification in 64 hemodialysis patients. Bone-related laboratory parameters and bone histomorphometric characteristics were assessed at baseline and after 1 year of follow-up. Low-turnover bone disease correlated with coronary artery calcification scores assessed by coronary multislice tomography and its progression.
  • 31
    • 0038187803 scopus 로고    scopus 로고
    • DHaese PC, Spasovski GB, Sikole A, et al. A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients. Kidney Int 2003; 63 (Suppl):S73-S78.
    • D"Haese PC, Spasovski GB, Sikole A, et al. A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients. Kidney Int 2003; 63 (Suppl):S73-S78.
  • 32
    • 66849101767 scopus 로고    scopus 로고
    • Low bone volume: A risk factor for coronary calcifications in hemodialysis patients
    • Adragao T, Herberth J, Monier-Faugere MC, et al. Low bone volume: a risk factor for coronary calcifications in hemodialysis patients. Clin J Am Soc Nephrol 2009; 4:450-455.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 450-455
    • Adragao, T.1    Herberth, J.2    Monier-Faugere, M.C.3
  • 33
    • 33847327503 scopus 로고    scopus 로고
    • Low-calcium dialysate improves mineral metabolism in hemodialysis patients
    • Fugimori A, Yorifuji M, Sakai M, et al. Low-calcium dialysate improves mineral metabolism in hemodialysis patients. Clin Nephrol 2007; 67:20-24.
    • (2007) Clin Nephrol , vol.67 , pp. 20-24
    • Fugimori, A.1    Yorifuji, M.2    Sakai, M.3
  • 34
    • 33747821066 scopus 로고    scopus 로고
    • Reversal of adynamic bone disease by lowering of dialysate calcium
    • Haris A, Sherrard DJ, Hercz G. Reversal of adynamic bone disease by lowering of dialysate calcium. Kidney Int 2006; 70:931-937.
    • (2006) Kidney Int , vol.70 , pp. 931-937
    • Haris, A.1    Sherrard, D.J.2    Hercz, G.3
  • 35
    • 59849108347 scopus 로고    scopus 로고
    • Igarashi P, Aronson PS. Late-breaking clinical trials at renal week 2008. Clin J Am Soc Nephrol 2008; 3:RB01-RB04. One of the abstracts in this special session at the Renal Week 2008 presented a study conducted in a large population of prevalent dialysis patients with a follow-up of 24 months. In this bone biopsy study, the authors showed that lowering dialysate Ca level induced an improvement in bone turnover, bone formation and reduced coronary artery calcifications progression evaluated by multislice CT.
    • Igarashi P, Aronson PS. Late-breaking clinical trials at renal week 2008. Clin J Am Soc Nephrol 2008; 3:RB01-RB04. One of the abstracts in this special session at the Renal Week 2008 presented a study conducted in a large population of prevalent dialysis patients with a follow-up of 24 months. In this bone biopsy study, the authors showed that lowering dialysate Ca level induced an improvement in bone turnover, bone formation and reduced coronary artery calcifications progression evaluated by multislice CT.
  • 36
    • 0028035183 scopus 로고
    • Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy
    • Goodman WG, Ramirez JA, Belin TR, et al. Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy. Kidney Int 1994; 46:1160-1166.
    • (1994) Kidney Int , vol.46 , pp. 1160-1166
    • Goodman, W.G.1    Ramirez, J.A.2    Belin, T.R.3
  • 37
    • 0031888062 scopus 로고    scopus 로고
    • Diminished linear growth during intermittent calcitriol therapy in children undergoing CCPD
    • Kuizon BD, Goodman WG, Juppner H, et al. Diminished linear growth during intermittent calcitriol therapy in children undergoing CCPD. Kidney Int 1998; 53:205-211.
    • (1998) Kidney Int , vol.53 , pp. 205-211
    • Kuizon, B.D.1    Goodman, W.G.2    Juppner, H.3
  • 38
    • 20844459261 scopus 로고    scopus 로고
    • Activated injectable vitamin D and hemodialysis survival: A historical cohort study
    • Teng M, Wolf M, Ofsthun MN, et al. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol 2005; 16:1115-1125.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1115-1125
    • Teng, M.1    Wolf, M.2    Ofsthun, M.N.3
  • 39
    • 33745210682 scopus 로고    scopus 로고
    • Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients
    • Kalantar-Zadeh K, Kuwae N, Regidor DL, et al. Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients. Kidney Int 2006; 70:771-780.
    • (2006) Kidney Int , vol.70 , pp. 771-780
    • Kalantar-Zadeh, K.1    Kuwae, N.2    Regidor, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.