Evidence of extranuclear cell sensitivity to alpha-particle radiation using a microdosimetric model. I. Presentation and validation of a microdosimetric model

Radiation Research

Volumn 171, Issue 6, 2009, Pages 657-663

  Chouin, N ^a   Bernardeau, K ^a   Davodeau, F ^a   Cherel M ^a,b   Faivre Chauvet, A ^a   Bourgeois, M ^a   Apostolidis, C ^c   Morgenstern, A ^c   Lisbona, A ^a,d   Bardis, M ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c JOINT RESEARCH CENTRE   (Italy)

^d CLCC Nantes Atlantique Ren Gauducheau ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; ALPHA RADIATION; ANALYTIC METHOD; ARTICLE; CELL ISOLATION; CELL NUCLEUS; CELL SURVIVAL; ENERGY; INTERMETHOD COMPARISON; MICRODOSIMETRY; MODEL; MONOLAYER CULTURE; MONTE CARLO METHOD; PRIORITY JOURNAL; RADIOSENSITIVITY; VALIDATION PROCESS; WHOLE CELL; CELL; CELL MEMBRANE; COMPUTER PROGRAM; CYTOPLASM; METHODOLOGY; RADIATION EXPOSURE; RADIOMETRY; SPECTROSCOPY; THEORETICAL MODEL; TIME;

ALGORITHMS; ALPHA PARTICLES; CELL MEMBRANE; CELL NUCLEUS; CELL SURVIVAL; CELLS; CYTOPLASM; MODELS, THEORETICAL; MONTE CARLO METHOD; RADIOMETRY; SOFTWARE; SPECTRUM ANALYSIS; TIME FACTORS;

EID: 67849092565     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1371.1     Document Type: Article

References (35)

1. R. M. Macklis, B. M. Kinsey, A. I. Kassis, J. L. Ferrara, R. W. Atcher, J. J. Hines, C. N. Coleman, S. J. Adelstein and S. J. Burakoff, Radioimmunotherapy with alpha-particle-emitting immunoconjugates. Science 240, 1024-1026 (1988).
2. J. G. Jurcic, S. M. Larson, G. Sgouros, M. R. McDevitt, R. D. Finn, C. R. Divgi, A. M. Ballangrud, K. A. Hamacher, D. Ma and D. A. Scheinberg, Targeted alpha particle immunotherapy for myeloid leukemia. Blood 100, 1233-1239 (2002).
3. 211At-labeled chimeric antitenascin monoclonal antibody 81C6. J. Nucl. Med. 49, 30-38 (2008).
4. B. J. Allen, C. Raja, S. Rizvi, Y. Li, W. Tsui, P. Graham, J. F. Thompson, R. A. Reisfeld and J. Kearsley, Intralesional targeted alpha therapy for metastatic melanoma. Cancer Biol. Ther. 4, 1318-1324 (2005).
5. B. J. Allen, C. Raja, S. Rizvi, E. Y. Song and P. Graham, Tumour anti-vascular alpha therapy: a mechanism for the regression of solid tumours in metastatic cancer. Phys. Med. Biol. 52, L15-L19 (2007).
6. S. Nilsson, R. H. Larsen, S. D. Fossa, L. Balteskard, K. W. Borch, J. E. Westlin, G. Salberg and O. S. Bruland, First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases. Clin. Cancer Res. 11, 4451-4459 (2005).
7. M. R. McDevitt, G. Sgouros, R. D. Finn, J. L. Humm, J. G. Jurcic, S. M. Larson and D. A. Scheinberg, Radioimmunotherapy with alpha-emitting nuclides. Eur. J. Nucl. Med. 25, 1341-1351 (1998).
8. ICRU, Stopping Powers and Ranges for Protons and α Particles. Report 49, International Commission on Radiation Units and Measurements, Bethesda, MD, 1993.
9. E. J. Hall, Radiobiology for the Radiologist, 2nd ed. Harper and Row, Hagerstown, MD, 1978.
10. M. Bardiés and P. Pihet, Dosimetry and microdosimetry of targeted radiotherapy. Curr. Pharm. Des. 6, 1469-1502 (2000).
11. T. R. Munro, The relative radiosensitivity of the nucleus and cytoplasm of Chinese hamster fibroblasts. Radiat. Res. 42, 451-470 (1970).
12. C. Soyland and S. P. Hassfjell, Survival of human lung epithelial cells following in vitro alpha-particle irradiation with absolute determination of the number of alpha-particle traversals of individual cells. Int. J. Radiat. Biol. 76, 1315-1322 (2000).
13. J. L. Humm, J. C. Roeske, D. R. Fisher and G. T. Chen, Microdosimetric concepts in radioimmunotherapy. Med. Phys. 20, 535-541 (1993).
14. ICRU, Microdosimetry. Report 36, International Commission on Radiation Units and Measurements, Washington, DC, 1983.
15. W. C. Roesch, Microdosimetry of internal sources. Radiat. Res. 70, 494-510 (1977).
16. T. G. Stinchcomb and J. C. Roeske, Analytic microdosimetry for radioimmunotherapeutic alpha emitters. Med. Phys. 19, 1385-1393 (1992).
17. R. H. Larsen, G. Akabani, P. Welsh and M. R. Zalutsky, The cytotoxicity and microdosimetry of astatine-211-labeled chimeric monoclonal antibodies in human glioma and melanoma cells in vitro. Radiat. Res. 149, 155-162 (1998).
18. E. Aurlien, R. H. Larsen, G. Akabani, D. R. Olsen, M. R. Zalutsky and O. S. Bruland, Exposure of human osteosarcoma and bone marrow cells to tumour-targeted alpha-particles and gamma-irradiation: analysis of cell survival and microdosimetry. Int. J. Radiat. Biol. 76, 1129-1141 (2000).
19. D. E. Charlton, Radiation effects in spheroids of cells exposed to alpha emitters. Int. J. Radiat. Biol. 76, 1555-1564 (2000).
20. S. Palm, J. L. Humm, R. Rundqvist and L. Jacobsson, Microdosimetry of astatine-211 single-cell irradiation: role of daughter polonium-211 diffusion. Med. Phys. 31, 218-225 (2004).
21. Y. Kvinnsland, T. Stokke and E. Aurlien, Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nuclei. Radiat. Res. 155, 288-296 (2001).
22. P. V. Neti and R. W. Howell, Log normal distribution of cellular uptake of radioactivity: implications for biologic responses to radiopharmaceuticals. J. Nucl. Med. 47, 1049-1058 (2006).
23. G. W. Barendsen and H. M. Walter, Effects of different ionizing radiations on human cells in tissue culture. IV. Modification of radiation damage. Radiat. Res. 21, 314-329 (1964).
24. J. L. Humm, A microdosimetric model of astatine-211 labeled antibodies for radioimmunotherapy. Int. J. Radiat. Oncol. Biol. Phys. 13, 1767-1773 (1987).
25. J. L. Humm and L. M. Chin, A model of cell inactivation by alphaparticle internal emitters. Radiat. Res. 134, 143-150 (1993).
26. D. E. Charlton and R. Sephton, A relationship between microdosimetric spectra and cell survival for high-LET irradiation. Int. J. Radiat. Biol. 59, 447-457 (1991).
27. T. G. Stinchcomb and J. C. Roeske, Analysis of survival of C-18 cells after irradiation in suspension with chelated and ionic bismuth-212 using microdosimetry. Radiat. Res. 140, 48-54 (1994).
28. J. S. Hendricks, MCNPX extensions version 2.5.0. LA-UR-04-0570, Los Alamos National Laboratory, Los Alamos, NM, 2004.
29. S. Agostinelli, J. Allison and K. Amako, GEANT4 - a simulation toolkit. Nucl. Instrum. Methods Phys. Res. A 506, 250-255 (2003).
30. TM - A general Monte Carlo N-particle transport code, version 4B. LA-12625-M, Los Alamos National Laboratory, Los Alamos, NM, 1997.
31. S. P. Ahlen, Theoretical and experimental aspects of the energy loss of relativistic heavily ionizing particles. Rev. Mod. Phys. 52, 121173 (1980).
32. N. Bohr, The penetration of atomic particles through matter. Kgl. Danske Videnskab. Selskab. Matt-Fys. Medd. 18, 8 (1948).
33. J. C. Roeske and M. Hoggarth, Alpha-particle Monte Carlo simulation for microdosimetric calculations using a commercial spreadsheet. Phys. Med. Biol. 52, 1909-1922 (2007).
34. A. M. Kellerer, Analysis of patterns of energy deposition; a survey of theoretical relations in microdosimetry. In Proceedings of the Second Symposium in Microdosimetry, Stresa, Italy (H. G. Ebert, Ed.), pp. 107-134. EUR 4452 d-f-e, Commission of the European Communities, Luxembourg, 1970.
35. A. M. Kellerer and D. Chmelevsky, Criteria for the applicability of LET. Radiat. Res. 63, 226-234 (1975).