The cytotoxicity and microdosimetry of astatine-211-labeled chimeric monoclonal antibodies in human glioma and melanoma cells in vitro

Radiation Research

Volumn 149, Issue 2, 1998, Pages 155-162

  Larsen, Roy H ^a   Akabani, Gamal ^a   Welsh, Phil ^a   Zalutsky, Michael R ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASTATINE 211; CHIMERIC ANTIBODY; CHONDROITIN SULFATE; L SELECTIN; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; TENASCIN;

ALPHA RADIATION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EXTRACELLULAR MATRIX; GLIOMA; HUMAN; HUMAN CELL; MELANOMA; MICRODOSIMETRY; PRIORITY JOURNAL; RADIATION DOSE; RADIOIMMUNOTHERAPY;

ANTIBODIES, MONOCLONAL; ASTATINE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, RADIATION; GLIOMA; HUMANS; IMMUNOTOXINS; MELANOMA; TUMOR CELLS, CULTURED;

EID: 0031908544     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579925     Document Type: Article

References (23)

1. M. R. Zalutsky and D. D. Bigner, Radioimmunotherapy with α-particle emitting radioimmunoconjugates. Acta Oncol. 35, 373-379 (1996).
2. G. Vaidyanathan and M. R. Zalutsky, Targeted therapy using alpha emitters. Phys. Med. Biol. 41, 1915-1931 (1996).
3. G. W. Barendsen, The relationship between RBE and LET for different types of lethal damage in mammalian cells: Biophysical and molecular mechanisms. Radiat. Res. 139, 257-270 (1994).
4. 2 - a preliminary report. J. Neuro-Oncol. 24, 109-122 (1995).
5. B. Fertil and E. P. Malaise, Intrinsic radiosensitivity of human cell lines is correlated with radioresponsivness of human tumors: Analysis of 101 published survival curves. Int. J. Radiat. Oncol. Biol. Phys. 11, 1699-1707 (1985).
6. X. He, G. E. Archer, C. J. Wikstrand, S. L. Morrison, M. R. Zalutsky, D. D. Bigner and S. K. Batra, Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. J. Neuroimmunol. 52, 127-137 (1994).
7. S. K. Batra, M. L. Niswonger, C. J. Wikstrand, C. N. Pegram, M. R. Zalutsky, S. L. Morrison and D. D. Bigner, Mouse/human chimeric Me1-14 antibody: Genomic cloning of the variable region genes, linkage to human constant region genes, expression and characterization. Hybridoma 13, 87-97 (1994).
8. M. R. Zalutsky, G. A. Archer, P. K. Garg, S. K. Batra and D. D. Bigner, Chimeric anti-tenascin antibody 81C6: Increased tumor localization compared with its murine parent. Nucl. Med. Biol. 23, 449-458 (1996).
9. J. L. Dangl, T. Wensel, S. L. Morrison, L. Stryer, L. A. Herzenberg and V. T. Oi, Segmental flexibility of genetically engineered chimeric human, rabbit, and mouse antibodies. EMBO J. 7, 1989-1994 (1988).
10. 211 At reaction. Appl. Radiat. Isot. 47, 135-143 (1996).
11. 2 fragments with the α-particle emitting nuclide astatine-211: Preservation of immunoreactivity and in vivo localizing capacity. Proc. Natl. Acad. Sci. USA 86, 7149-7153 (1989).
12. S. H. Bigner, J. Mark, P. C. Burger, S. M. Mahaley, Jr., D. E. Bullard, L. H. Muhlbaier and D. D. Bigner, Specific chromosomal abnormalities in malignant human gliomas. Cancer Res. 88, 405-411 (1988).
13. J. Yuan, Estimation of variance for AUC in animal studies. J. Pharm. Sci. 82, 761-763 (1993).
14. ICRU, Stopping Powers and Ranges for Protons and Alpha Particles. Report 49, International Commission on Radiation Units and Measurements, Bethesda, MD, 1992.
15. T. G. Stinchcomb and J. C. Roeske, Analysis of survival of C-18 cells after irradiation in suspension with chelated and ionic bismuth-212 using microdosimetry. Radiat. Res. 140, 48-54 (1994).
16. J. L. Humm and L. M. Chin, A model for cell inactivation by α-particle internal emitters. Radiat. Res. 134, 143-150 (1993).
17. J. C. Roeske and T. G. Stinchcomb, Relationships between cell survival and specific energy spectra for therapeutic alpha-particle emitters. Radiat. Res. 145, 268-273 (1996).
18. 211At-TP-3 monoclonal antibody: Comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays. Radiat. Res. 139, 178-184 (1994).
19. 211At-labelled monoclonal antibody. Br. J. Cancer 69, 1000-1005 (1994).
20. M. L. Hauck, M. W. Dewhirst and M. R. Zalutsky, The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody. Nucl. Med. Biol. 23, 551-557 (1996).
21. R. M. Macklis, J. Y. Lin, B. Beresford, R. W. Atcher, J. J. Hines and J. L. Humm, Cellular kinetics, dosimetry, and radiobiology of α-particle radioimmunotherapy: Induction of apoptosis. Radiat. Res. 130, 220-226 (1992).
22. M. R. Raju, Y. Eisen, S. Carpenter and W. C. Inkret, Radiobiology of α particles. III. Cell inactivation by α-particle traversais of the cell nucleus. Radiat. Res. 128, 204-209 (1991).
23. 210Po alpha particles on survival and preneoplastic transformation of primary rat tracheal epithelial cells irradiated while in suspension or in the intact tissue. Radiat. Res. 135, 89-96 (1993).