Exposure of human osteosarcoma and bone marrow cells to tumour-targeted α-particles and γ-irradiation: Analysis of cell survival and microdosimetry

International Journal of Radiation Biology

Volumn 76, Issue 8, 2000, Pages 1129-1141

  Aurlien, E ^a   Larsen, R H ^b   Akabani, G ^c   Olsen, D R ^a   Zalutsky, M R ^c   Bruland, O S ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60;

ALPHA RADIATION; ANTIGEN EXPRESSION; AREA UNDER THE CURVE; ARTICLE; BONE MARROW CELL; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; GAMMA RADIATION; HUMAN; HUMAN CELL; MICRODOSIMETRY; OSTEOSARCOMA CELL; PRIORITY JOURNAL; RADIATION INJURY;

EID: 0033914181     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000050111604     Document Type: Article

References (44)

1. AXDERSON, P. M., MEYERS, D. E., HASZ, D. E., COVALCUIC, K., SALTZMAN, D., KHANNA, C. and UCKUN, F. M., 1995, In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein. Cancer Research, 55, 1321-1327.
2. AKABANI, G. and ZALUTSKY, M. R., 1997, Microdosimetry of astatine-211 using histological images: application to bone marrow. Radiation Research, 148, 599-607.
3. BARENDSEN, G. W., KOOT, C. J., VAN KERSEN, G. R., BEWLEY, D. K., FIELD, S. B. and PARNELL, C. J., 1965, The effect of oxygen on impairment of the proliferative capacity of human cells in culture by ionizing radiations of different LET. International Journal of Radiation Oncology, Biology, Physics, 10, 317-327.
4. BOYUM, A., 1976, Isolation of lymphocytes, granulocytes, and macrophages. Scandinavian Journal of Immunology, 5, 9-15.
5. BRULAND, O. S., FODSTAD, O., AAS, M., SOLHEIM, O. P., HOIE, J., SKRETTING, A., WINDEREN, M., MICHAELSEN, T. and PIHL, A., 1994, Immunoscintigraphy of bone sarcomas -results in 5 patients. European Journal of Cancer, 30A, 1484-1489.
6. BRULAND, O., FODSTAD, O., FUNDERUD, S. and PIHL, A., 1986, New monoclonal antibodies specific for human sarcomas. International Journal of Cancer, 38, 27-31.
7. BRULAND, O., FODSTAD, O., SKRETTING, A. and PIHL, A., 1987, Selective localisation of two radiolabellod anti-sarcoma monoclonal antibodies in human osteosarcoma xenografts. British Journal of Cancer, 56, 21-25.
8. BRULAND, O. S., FODSTAD, O., STENWIG, A. E. and PIHL, A., 1988, Expression and characteristics of a novel human osteosarcoma-associated cell surface antigen. Cancer Research, 48, 5302-5309.
9. 211At-labeled antibodies in vitro. Scandinavian Symposium in Radiation Oncology, p. 52 (Abstract).
10. BRULAND, O. S. and PIHL, A., 1997, On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy. European Journal of Cancer, 33, 1725-1731.
11. CHARLTON, D. E., UTTERIDGE, T. D. and ALLEN, B. J., 1998, Theoretical treatment of human haemopoietic stem cell survival following irradiation by alpha particles. International Journal of Radiation Biology, 74, 111-118.
12. DOUAY, L., GORIN, N. C., LAPORTE, J. P., LOPEZ, M., NAJMAN, A. and DUHAMEL, G., 1984, ASTA Z 7557 (INN mafosfamide) for the in vitro treatment of human leukemic bone marrows. Investigational New Drugs, 2, 187-190.
13. EAVES, C. J., 1996, Myclopoiesis. In Leukemia, 6th edition, edited by E. S. Henderson, T. A. Lister and M. F. Greaves (London: Saunders Company), pp. 46-63.
14. FODSTAD, O., BROGGER, A., BRULAND, O., SOLHEIM, O. P., NESLAND, J. M. and PIHL, A., 1986, Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma. International Journal of Cancer, 38, 33-40.
15. GORIN, N. C., 1986, Autologous bone marrow transplantation in acute leukemia. Journal of National Cancer Institute, 76, 1281-1287.
16. GORIN, N. C., AEGERTER, P., AUVERT, B., MELONI, G., GOLDSTONE, A. H., BURNETT, A., CARELLA, A., KORBLING, M., HERVE, P. and MARANINCHI, D., 1990, Autologous bone marrow transplantation for acute myclocytic leukemia in first remission: a European survey of the role of marrow purging. Blood, 75, 1606-1614.
17. HAINES, D. M., BRULAND, O. S., MATTE, G., WILKINSON, A. A., MERIC, S. M. and FOWLER, J. D., 1992, Immunoscintigraphic detection of primary and metastatic spontaneous canine osteosarcoma with F(ab')2 fragments of osteosarcoma-associated monoclonal antibody TP-1. Anticancer Research, 12, 2151-2157.
18. HALL, E. J., 1994a, Linear energy transfer and relative biological effectiveness. In Radiobiology for the Radiologist, 4th edition (Philadelphia, PA: J. B. Lippincott Company), pp. 153-164.
19. HALL, E. J., 1994b, Cell survival curves. In Radiobiology for the Radiologist, 4th edition (Philadelphia, PA: J. B. Lippincott Company), pp. 29-44.
20. HARTER, K. W., 1994, Osteosarcoma and less common sarcomas of childhood. In Radiation Therapy in Pediatric Oncology, edited by J. R. Cassady (Berlin: Springer-Verlag), pp. 305-317.
21. HOVIG, E., ANDREASSEN, A., FANGAN, B. M. and BORRESEN, A. L., 1992, A TP53 mutation detected in cells established from an osteosarcoma, but not in the retinoblastoma of a patient with bilateral retinoblastoma and multiple primary osteosarcomas. Cancer Genetics and Cytogenetics, 64, 178-182.
22. KASSIS, A. I., HARRIS, C. R., ADELSTEIN, S. J., RUTH, T. J., LAMBRECHT, R. and WOLF, A. P., 1986, The in vitro radiobiology of astatine-211 decay. Radiation Research, 105, 27-36.
23. KIMLER, B. F., PARK, C. H., YAKAR, D. and MIES, R. M., 1984, Lack of recovery from radiation-induced sublethal damage in human haematopoietic cells. British Journal of Cancer, 6, 221-225.
24. LARSEN, R. H., AKABANI, G., WELSH, P. and ZALUTSKY, M. R., 1998, The cytotoxicity and microdosimetry of astatine-211-labeled chimeric monoclonal antibodies in human glioma and melanoma cells in vitro. Radiation Research, 149, 155-162.
25. LARSEN, R. H., BRULAND, O. S., HOFF, P., ALSTAD, J., LINDMO, T. and ROFSTAD, E. K., 1994b, Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays. Radiation Research, 139, 178-184.
26. LARSEN, R. H., BRULAND, O. S., HOFF, P., ALSTAD, J. and ROFSTAD, E. K., 1994a, Analysis of the therapeutic gain in the treatment of human osteosarcoma microcolonies in vitro with 211At-labelled monoclonal antibody. British Journal of Cancer, 69, 1000-1005.
27. 211At-labelling of polymer particles for radio-therapy: synthesis, purification and stability. Journal of Labelled Compounds and Radiopharmaceuticals, XXXIII, 977-986.
28. 125I-labelled monoclonal antibodies. Biodistribution in mice carrying human osteosarcoma xenografts. Journal of labelled Compounds and Radiopharmaceuticals, XXXIV, 774-785.
29. LORIMORE, S. A., GOODHEAD, D. T. and WRIGHT, E. G., 1993, Inactivation of haeniopoietic stem cells by slow alpha-particles. International Journal of Radiation Biology, 63, 655-660.
30. MALAWER, M. M., LINK, M. P. and DONALDSON, S. S., 1997, Sarcomas of bone. In Cancer. Principles and Practice of Oncology, 5th edition, edited by V. T. J. DeVita, S. Hellman and S. A. Rosenberg (Philadelphia, New York: Lippincott Raven Publishers), pp. 1789-1852.
31. OLSEN, D. R. and BRULAND, O. S., 1998, Is osteosarcoma a radioresistant tumor? A radiobiological enigma. Osteosarcoma Odyssey, pp. 73-76 (Abstract).
32. PAGE, R. L., GARG, P. K., GARG, S., ARCHER, G. E., BRULAND, O. S. and ZALUTSKY, M. R., 1994, PET imaging of osteosarcoma in dogs using a fluorine-18-labeled monoclonal antibody Fab fragment. Journal of Nuclear Medicine, 35, 1506-1513.
33. PALM, S., BACK, T., CLAESSON, I., DELLE, U., HULTBORN, R., JACOBSSON, L., KOPF, I. and LINDEGREN, S., 1998, Effects of the alpha-particle emitter At-211 and low-dose-rate gamma-radiation on the human cell line Colo-205 as studied with a growth assay. Anticancer Research, 18, 1671-1676.
34. RITTER, M. A., CLEAVER, J. E. and TOBIAS, C. A., 1977, High-LET radiations induce a large proportion of non-rejoining DNA breaks. Nature, 266, 653-655.
35. SAETER, G., BRULAND, O. S., FOLLERAS, G., BOYSEN, M. and HOIE, J., 1996, Extremity and non-extremity high-grade osteosarcoma - the Norwegian Radium Hospital experience during the modern chemotherapy era. Acta Oncologica, 35 (Suppl. 8), 129-134.
36. SOUHAMI, R. and GANXON, S. R., 1995, Osteosarcoma. In Oxford Textbook of Oncology, edited by M. Peckham, H. M. Pinedo and U. Veronesi (Oxford: Oxford University Press), pp. 1969-1976.
37. TVEIT, K. M., FODSTAD, O., OLSNES, S. and PIHL, A., 1980, In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. International Journal Cancer, 26, 717-722.
38. UCKUN, F. M., EK, O., WAURZYNIAK, B. and MYERS, D. E., 1998, Antitumor activity of TP3(anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of osteosarcoma. Osteosarcoma Odyssey, pp. 120-124 (Abstract).
39. UCKUN, F. M. and SONG, G. W., 1989, Radiobiological features of human pluripotent bone marrow progenitor cells (CFU-GEMM). International Journal of Radiation Oncology, Biology, Physics, 17, 1021-1025.
40. VAIDYANATHAN, G. and ZALUTSKY, M. R., 1996, Targeted therapy using alpha emitters. Physics in Medicine and Biology, 41, 1915-1931.
41. 211At labelled lectins and antibodies I. International Journal of Nuclear Medicine and Biology, 9, 167-171.
42. WARD, P., HAINES, D. M., MISRA, V. and UCKUN, F. M., 1998, Charactcrization of the p80 osteosarcoma-associated antigen. Osteosarcoma Odyssey, p. 114 (Abstract).
43. WEICHSELBAUM, R. R., BECKETT, M. A., SIMON, M. A., MCCAULEY, C., HARAF, D., AWAN, A., SAMUELS, B., NACHMAN, J. and DRITSCHILO, A., 1988, In vitro radiobiological parameters of human sarcoma cell lines. International Journal of Radiation Oncology, Biology, Physics, 15, 937-942.
44. YUAN, J., 1993, Estimation of variance of AUC in animal studies. Journal of Pharmaceutical Sciences, 82, 761-763.