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This study used SEER data from 13 geographic regions in the United States matched with data from the Adult and Adolescent Spectrum of HIV Disease Project and the HIV Outpatient Study showing an increase in the incidence of anal cancer increased in the post-ART era compared with the pre-ART era
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Patel P, Hanson DL, Sullivan PS, et al. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003. Ann Intern Med 2008; 148:728-736. This study used SEER data from 13 geographic regions in the United States matched with data from the Adult and Adolescent Spectrum of HIV Disease Project and the HIV Outpatient Study showing an increase in the incidence of anal cancer increased in the post-ART era compared with the pre-ART era.
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This is the first population-based study of the prevalence of anal HPV infection and AIN in HIV-positive and HIV-negative MSM. The data were consistent with earlier studies from convenience cohorts. This study also showed that MSM with no prior experience with anal cytology screening could successfully auto-collect samples for anal cytology
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Chin-Hong PV, Berry JM, Cheng S-C, et al. A population-based study of human papillomavirus-associated anal neoplasia in HIV-positive and HIV-negative men using self-collected specimens: the TPOP study. Annals Int Med 2008; 149:300-306. This is the first population-based study of the prevalence of anal HPV infection and AIN in HIV-positive and HIV-negative MSM. The data were consistent with earlier studies from convenience cohorts. This study also showed that MSM with no prior experience with anal cytology screening could successfully auto-collect samples for anal cytology.
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This study showed that a high proportion of HGAIN lesions could be successfully treated in HIV-negative MSM using IRC
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Goldstone SE, Hundert JS, Huyett JW. Infrared coagulator ablation of high-grade anal squamous intraepithelial lesions in HIV-negative males who have sex with males. Dis Colon Rectum 2007; 50:565-575. This study showed that a high proportion of HGAIN lesions could be successfully treated in HIV-negative MSM using IRC.
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Cranston RD, Hirschowitz SL, Cortina G, Moe AA. A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men. Int J STD AIDS 2008; 19:118-120. This retrospective analysis showed that a high proportion of HGAIN lesions could be successfully treated in HIV-positive MSM using IRC. (Pubitemid 351738818)
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International Journal of STD and AIDS
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Wieland U, Brockmeyer NH, Weissenborn SJ, et al. Imiquimod treatment of anal intraepithelial neoplasia in HIV-positive men. Arch Dermatol 2006; 142:1438-1444. (Pubitemid 44790637)
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Kreuter A, Potthoff A, Brockmeyer NH, et al. Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men. J Invest Dermatol 2008; 128:2078-2083. This study showed that treatment with topical imiquimod cleared a high proportion of intra-anal and peri-anal HGAIN in HIV-positive individuals. (Pubitemid 352001209)
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Kreuter A, Wieland U, Gambichler T, et al. p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load. Br J Dermatol 2007; 157:523-530. (Pubitemid 47256116)
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This study was the first to describe the use of laser therapy to clear a high proportion of HGAIN lesions. Cure rates by HIV status were not reported, and the median time to cure was longer among HIV-positive patients compared with HIV-negative patients
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Nathan M, Hickey N, Mayuranathan L, et al. Treatment of anal human papillomavirus-associated disease: a long term outcome study. Int J STD AIDS 2008; 19:445-449. This study was the first to describe the use of laser therapy to clear a high proportion of HGAIN lesions. Cure rates by HIV status were not reported, and the median time to cure was longer among HIV-positive patients compared with HIV-negative patients.
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Int J STD AIDS
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Chang GJ, Berry JM, Jay N, et al. Surgical treatment of high-grade anal squamous intraepithelial lesions: a prospective study. Dis Colon Rectum 2002; 45:453-458. (Pubitemid 34407722)
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This study revisits the efficacy of surgery to treat HIV-positive patients with extensive HGAIN. Combined with postoperative IRC to treat persistent or recurrent HGAIN, a high proportion (78%) of patients were cleared of HGAIN. These data suggest that treatment of patients with extensive HGAIN may also be successful
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Pineda CE, Berry JM, Jay N, et al. High resolution anoscopy targeted surgical destruction of anal high-grade squamous intraepithelial lesions: a ten year experience. Dis Col Rectum 2008; 1:829-835. This study revisits the efficacy of surgery to treat HIV-positive patients with extensive HGAIN. Combined with postoperative IRC to treat persistent or recurrent HGAIN, a high proportion (78%) of patients were cleared of HGAIN. These data suggest that treatment of patients with extensive HGAIN may also be successful.
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Dis Col Rectum
, vol.1
, pp. 829-835
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Pineda, C.E.1
Berry, J.M.2
Jay, N.3
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