Epstein-Barr virus protein kinase BGLF4 interacts with viral transactivator BZLF1 and regulates its transactivation activity

Journal of General Virology

Volumn 90, Issue 7, 2009, Pages 1575-1581

  Asai, Risa ^a,b   Kato, Ai ^b   Kawaguchi, Yasushi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMEDIATE EARLY PROTEIN BZLF1; PROTEIN KINASE BGLF4; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; BGLF4 PROTEIN, EPSTEIN BARR VIRUS; BGLF4 PROTEIN, EPSTEIN-BARR VIRUS; BZLF1 PROTEIN, HERPESVIRUS 4, HUMAN; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOREGULATION; CATALYSIS; COMPLEX FORMATION; DELETION MUTANT; DOWN REGULATION; EPSTEIN BARR VIRUS; GENE INTERACTION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; ANIMAL; CELL LINE; CERCOPITHECUS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN ANALYSIS; SITE DIRECTED MUTAGENESIS;

HUMAN HERPESVIRUS 4;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; HUMANS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN INTERACTION MAPPING; PROTEIN-SERINE-THREONINE KINASES; TRANS-ACTIVATORS; VIRAL PROTEINS;

EID: 67849088972     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.010462-0     Document Type: Article

References (33)

1. Asai, R., Kato, A., Kato, K., Kanamori-Koyama, M., Sugimoto, K., Sairenji, T., Nishiyama, Y. & Kawaguchi, Y. (2006). Epstein-Barr virus protein kinase BGLF4 is a virion tegument protein that dissociates from virions in a phosphorylation-dependent process and phosphorylates the viral immediate-early protein BZLF1. J Virol 80, 5125-5134.
2. Chee, M. S., Lawrence, G. L. & Barrell, B. G. (1989). Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase. J Gen Virol 70, 1151-1160.
3. Chen, M. R., Chang, S. J., Huang, H. & Chen, J. Y. (2000). A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro. J Virol 74, 3093-3104.
4. Flemington, E. & Speck, S. H. (1990). Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1. J Virol 64, 1227-1232.
5. Gershburg, E. & Pagano, J. S. (2002). Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the L-riboside benzimidazole 1263W94. J Virol 76, 998-1003.
6. Gershburg, E., Marschall, M., Hong, K. & Pagano, J. S. (2004). Expression and localization of the Epstein-Barr virus-encoded protein kinase. J Virol 78, 12140-12146.
7. Gershburg, E., Raffa, S., Torrisi, M. R. & Pagano, J. S. (2007). Epstein-Barr virus-encoded protein kinase (BGLF4) is involved in production of infectious virus. J Virol 81, 5407-5412.
8. Izumiya, Y., Izumiya, C., Van Geelen, A., Wang, D. H., Lam, K. S., Luciw, P. A. & Kung, H. J. (2007). Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. J Virol 81, 1072-1082.
9. Johannsen, E., Luftig, M., Chase, M. R., Weicksel, S., Cahir-McFarland, E., Illanes, D., Sarracino, D. & Kieff, E. (2004). Proteins of purified Epstein-Barr virus. Proc Natl Acad Sci U S A 101, 16286-16291.
10. Kanamori, M., Watanabe, S., Honma, R., Kuroda, M., Imai, S., Takada, K., Yamamoto, N., Nishiyama, Y. & Kawaguchi, Y. (2004). Epstein-Barr virus nuclear antigen leader protein induces expression of thymus- and activation-regulated chemokine in B cells. J Virol 78, 3984-3993.
11. Kato, K., Kawaguchi, Y., Tanaka, M., Igarashi, M., Yokoyama, A., Matsuda, G., Kanamori, M., Nakajima, K., Nishimura, Y. & other authors (2001). Epstein-Barr virus-encoded protein kinase BGLF4 mediates hyperphosphorylation of cellular elongation factor 1d (EF-1δ): EF-1δ is universally modified by conserved protein kinases of herpesviruses in mammalian cells. J Gen Virol 82, 1457-1463.
12. Kato, K., Yokoyama, A., Tohya, Y., Akashi, H., Nishiyama, Y. & Kawaguchi, Y. (2003). Identification of protein kinases responsible for phosphorylation of Epstein-Barr virus nuclear antigen leader protein at serine-35, which regulates its coactivator function. J Gen Virol 84, 3381-3392.
13. Kato, A., Yamamoto, M., Ohno, T., Kodaira, H., Nishiyama, Y. & Kawaguchi, Y. (2005). Identification of proteins phosphorylated directly by the Us3 protein kinase encoded by herpes simplex virus 1. J Virol 79, 9325-9331.
14. Kato, A., Yamamoto, M., Ohno, T., Tanaka, M., Sata, T., Nishiyama, Y. & Kawaguchi, Y. (2006). Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates viral Us3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31. J Virol 80, 1476-1486.
15. Kato, A., Tanaka, M., Yamamoto, M., Asai, R., Sata, T., Nishiyama, Y. & Kawaguchi, Y. (2008). Identification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells. J Virol 82, 6172-6189.
16. Kato, A., Arii, J., Shiratori, I., Akashi, H., Arase, H. & Kawaguchi, Y. (2009). Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface. J Virol 83, 250-261.
17. Kawaguchi, Y. & Kato, K. (2003). Protein kinases conserved in herpesviruses potentially share a function mimicking the cellular protein kinase cdc2. Rev Med Virol 13, 331-340.
18. Kawaguchi, Y., Nakajima, K., Igarashi, M., Morita, T., Tanaka, M., Suzuki, M., Yokoyama, A., Matsuda, G., Kato, K. & other authors (2000). Interaction of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) with HS1-associated protein X-1: implication of cytoplasmic function of EBNA-LP. J Virol 74, 10104-10111.
19. Kawaguchi, Y., Tanaka, M., Yokoymama, A., Matsuda, G., Kato, K., Kagawa, H., Hirai, K. & Roizman, B. (2001). Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1. Proc Natl Acad Sci U S A 98, 1877-1882.
20. Kawaguchi, Y., Kato, K., Tanaka, M., Kanamori, M., Nishiyama, Y. & Yamanashi, Y. (2003). Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1δ. J Virol 77, 2359-2368.
21. Kenyon, T. K., Cohen, J. I. & Grose, C. (2002). Phosphorylation by the varicella-zoster virus ORF47 protein serine kinase determines whether endocytosed viral gE traffics to the trans-Golgi network or recycles to the cell membrane. J Virol 76, 10980-10993.
22. Kieff, E. D. & Rickinson, A. B. (2007). Epstein-Barr virus and its replication. In Fields Virology, 5th edn, pp. 2603-2654. Edited by D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman & S. E. Straus. Philadelphia, PA: Lippincott Williams & Wilkins.
23. Kudoh, A., Daikoku, T., Ishimi, Y., Kawaguchi, Y., Shirata, N., Iwahori, S., Isomura, H. & Tsurumi, T. (2006). Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4- MCM6-MCM7 complex during Epstein-Barr virus productive replication. J Virol 80, 10064-10072.
24. Lee, C. P., Chen, J. Y., Wang, J. T., Kimura, K., Takemoto, A., Lu, C. C. & Chen, M. R. (2007). Epstein-Barr virus BGLF4 kinase induces premature chromosome condensation through activation of condensin and topoisomerase II. J Virol 81, 5166-5180.
25. Mocarski, E. S., Shenk, T. & Pass, R. T. (2007). Cytomegaloviruses. In Fields Virology, 5th edn, pp. 2701-2772. Edited by D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman & S. E. Straus. Philadelphia, PA: Lippincott Williams & Wilkins.
26. Roizman, B., Knipe, D. M. & Whitley, R. J. (2007). Herpes simplex viruses. In Fields Virology, 5th edn, pp. 2501-2601. Edited by D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman & S. E. Straus. Philadelphia, PA: Lippincott Williams & Wilkins.
27. Sambrook, J. & Russell, D. W. (2001). Site-specific mutagenesis by overlap extension. In Molecular Cloning, 3rd edn, pp. 13.36-13.39. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
28. Smith, R. F. & Smith, T. F. (1989). Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus. J Virol 63, 450-455.
29. Wang, J. T., Yang, P. W., Lee, C. P., Han, C. H., Tsai, C. H. & Chen, M. R. (2005). Detection of Epstein-Barr virus BGLF4 protein kinase in virus replication compartments and virus particles. J Gen Virol 86, 3215-3225.
30. Yin, Q., Jupiter, K. & Flemington, E. K. (2004). The Epstein-Barr virus transactivator Zta binds to its own promoter and is required for full promoter activity during anti-Ig and TGF-β1 mediated reactivation. Virology 327, 134-143.
31. Yokoyama, A., Tanaka, M., Matsuda, G., Kato, K., Kanamori, M., Kawasaki, H., Hirano, H., Kitabayashi, I., Ohki, M. & other authors (2001). Identification of major phosphorylation sites of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP): ability of EBNA-LP to induce latent membrane protein 1 cooperatively with EBNA-2 is regulated by phosphorylation. J Virol 75, 5119-5128.
32. Yuan, J., Cahir-McFarland, E., Zhao, B. & Kieff, E. (2006). Virus and cell RNAs expressed during Epstein-Barr virus replication. J Virol 80, 2548-2565.
33. Yue, W., Gershburg, E. & Pagano, J. S. (2005). Hyperphosphorylation of EBNA2 by Epstein-Barr virus protein kinase suppresses transactivation of the LMP1 promoter. J Virol 79, 5880-5885.