Novel fabrication of PCL porous beads for use as an injectable cell carrier system

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 90 B, Issue 2, 2009, Pages 521-530

  Lim, Sung Mook ^a   Lee, Hyo Jung ^a,c   Oh, Se Heang ^a   Kim, Jin Man ^b   Lee, Jin Ho ^a  

^a Hannam University   (South Korea)

^b Chungnam National University College of Medicine   (South Korea)

^c Pharmaceutical R and D Center   (South Korea)

Author keywords

Cell carrie; Injectable; Pluronic F127; Polycaprolactone (PCL); Porous bead

Indexed keywords

CELL MEMBRANES; FABRICATION; GELATION; GELS; GROWTH KINETICS; LEACHING; PORE SIZE; PORE STRUCTURE;

BEAD SIZE; CELL CARRIER; CELL SEEDING DENSITY; CHONDROCYTE; DIFFERENT PORE SIZES; GEL STATE; GROWTH BEHAVIOR; IN-VITRO; INFLAMMATORY RESPONSE; INJECTABLE; INTERIOR POROSITY; LEACHING METHODS; MELTING METHOD; PLURONIC F127; POLYCAPROLACTONE (PCL); PORE SIZE EFFECT; POROUS BEAD; ROOM TEMPERATURE; TISSUE COMPATIBILITY;

POLYCAPROLACTONE;

POLOXAMER; POLYCAPROLACTONE;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; CARTILAGE CELL; CELL DENSITY; CELL GROWTH; CHEMICAL STRUCTURE; COLD; DISPERSION; GEL; HAIRLESS MOUSE; HISTOCOMPATIBILITY; HISTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LEACHING; MELTING POINT; MOUSE; NONHUMAN; PARTICLE SIZE; POROSITY; ROOM TEMPERATURE; SURFACE PROPERTY; TISSUE ENGINEERING;

EID: 67749149035     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31313     Document Type: Article

References (32)

1. Badylak SF. Extracellular matrix as a scaffold for tissue engineering in veterinary medicine: Applications to soft tissue healing. Clin Techn Equine Pract 2004;3:173-181.
2. Karande TS, Ong JL, Agrawal CM. Diffusion in musculoskeletal tissue engineering scaffolds: Design issues related to porosity, permeability, architecture, and nutrient mixing. Ann Biomed Eng 2004;32:1728-1743.
3. Bilodeau K, Mantovani D. Bioreactors for tissue engineering: Focus on mechanical constraints. A comparative review. Tissue Eng 2006;12:1-17.
4. Goldstein AS, Juarez TM, Helmke CD, Gustin MC, Mikos AG. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials 2001;22:1279-1288.
5. Fuchs JR, Terada S, Hannouche D, Ochoa ER, Vacanti JP, Fauza DO. Engineered fetal cartilage: Structural and functional analysis in vitro. J Pediatr Surg 2002;37:1720-1725. (Pubitemid 35416922)
6. Martin I, Wendt D, Heberer M. The role of bioreactors in tissue engineering. Trends Biotechnol 2004;22:80-86.
7. Gooch KJ, Kwon JH, Blunk T, Langer R, Freed LE, Vunjak- Novakovic G. Effects of mixing intersity on tissue-engineered cartilage. Biotechnol Bioeng 2001;72:402-407. (Pubitemid 32142441)
8. Croughan MS, Hamel JF, Wang DIC. Hydrodynamic effects on animal cells grown in microcarrier culture. Biotechnol Bioeng 1987;29:130-141. (Pubitemid 17531771)
9. Senuma Y, Franceschin S, Hilborn JG, Tissières P, Bisson I, Frey P. Bioresorbable microspheres by spinning disk atomization as injectable cell carrier: From preparation to in vitro evaluation. Biomaterials 2000;21:1135-1144. (Pubitemid 30173152)
10. Eiselt P, Yeh J, Latvala RK, Shea LD, Mooney DJ. Porous carriers for biomedical applications based on alginate hydrogels. Biomaterials 2000;21:1921-1927. (Pubitemid 30433820)
11. McGlohorn JB, Grimes LW, Webster SS, Burg KJL. Characterization of cellular carriers for use in injectable tissue-engineering composites. J Biomed Mater Res 2003;66A:441-449.
12. Sahoo SK, Panda AK, Labhasetwar V. Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells. Biomacromolecules 2005;6:1132-1139 (Pubitemid 40467862)
13. Kim TK, Yoon JJ, Lee DS, Park TG. Gas foamed open porous biodegradable polymeric microspheres. Biomaterials 2006; 27:152-159.
14. Tamasaki H, Sohmura T, Teraoka F, Yamamoto T, Hirose Y, Takahashi J, Niwa H. Fabrication of porous particulate for the scaffold by applying solution spraying method. Dent Mater J 2005;24:76-82. (Pubitemid 40978980)
15. Mi FL, Tan YC, Liang HF, Sung HW. In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials 2002;23:181-191.
16. Mercier NR, Costantino HR, Tracy MA, Bonassar LJ. A novel injectable approach for cartilage formation in vivo using PLG microspheres. Ann Biomed Eng 2004;32:418-429.
17. Dmochowski RR, Appell RA. Injectable agents in the treatment of stress urinary incontinence in women: Where are we now? Urology 2000;56(Suppl 6A):32-40.
18. Mooney D, Baldwin DF, Suh NP, Vacanti JP, Langer R. Novel approach to fabricate porous sponges of poly(D,L-lactic- co-glycolic acid) without the use of organic solvents. Biomaterials 1998;17:1417-1422. (Pubitemid 26237549)
19. Oh SH, Kang SG, Kim ES, Cho SH, Lee JH. Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/ poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate- leaching method. Biomaterials 2003;24:4011-4021.
20. Oh SH, Lee JY, Ghil SH, Lee SS, Yuk SH, Lee JH. PCL microparticle- dispersed PLGA solution as a potential injectable urethral bulking agent. Biomaterials 2006;27:1936-1944.
21. Smith MK, Peters MC, Richardson TP, Garbern JC, Mooney DJ. Locally enhanced angiogenesis promoters transplanted cell survival. Tissue Eng 2004;10:63-71.
22. Yoon JJ, Chung HJ, Lee HJ, Park TG. Heparin-immobilized biodegradable scaffolds for local and sustained release of angiogenic growth factor. J Biomed Mater Res 2006;79A: 934-942.
23. Nillesen STM, Geutjes PJ, Wismans R, Schalkwijk J, Daamen WF, van Kuppevelt TH. Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF. Biomaterials 2007;28:1123-1131. (Pubitemid 44809425)
24. Fuchs S, Motta A, Migliaresi C, Kirkpatrick CJ. Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells as a potential source of autologous cells for endothelialization of silk fibroin biomaterals. Biomaterials 2006;27:5399-5408. (Pubitemid 44093717)
25. Kang SW, Seo SW, Choi CY, Kim BS. Porous poly(lactic-coglycolic acid) microsphere as cell culture substrate and cell transplantation vehicle for adipose tissue engineering. Tissue Eng Part C 2008;14:25-34.
26. Oh SH, Park IK, Kim JM, Lee JH. In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 2007;28:1664-1671.
27. Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res 1993;27:11-23. (Pubitemid 23002763)
28. Freed LE, Vunjak-Novakovic G, Biron RJ, Eagles DB, Lesnoy DC, Barlow SK, Langer R. Biodegradable polymer scaffolds for tissue engineering. Biotechnology 1994;12:689-693. (Pubitemid 24187595)
29. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407:249-257.
30. Schmolka IR. A review of block polymer surfactants. J Am Oil Chem 1977;54:110-116.
31. Wanka G, Hoffman H, Ulbricht W. Phase-diagrams and aggregation behavior of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions. Macromolecules 1994;27:4145-4159.
32. Oh SH, Kim JK, Song KS, Noh SM, Ghil SH, Yuk SH, Lee JH. Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol-gel transition behavior. J Biomed Mater Res 2005;72A:306-316.