Medication problems in older, newly diagnosed cancer patients in canada: How common are they?: A prospective pilot study

Drugs and Aging

Volumn 26, Issue 6, 2009, Pages 519-536

  Puts, Martine T E ^a,b,g   Costa Lima, Beatriz ^a   Monette, Johanne ^a,c   Girre, Veronique ^c,d   Wolfson, Christina ^b,e   Batist, Gerald ^f   Bergman, Howard ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d INSTITUT CURIE   (France)

^e MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^f MCGILL UNIVERSITY   (Canada)

^g NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTITHROMBOCYTIC AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GASTROINTESTINAL AGENT; HORMONE; HYPOCHOLESTEROLEMIC AGENT; LAXATIVE; NEUROLEPTIC AGENT; NITRIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE DERIVATIVE; PARACETAMOL; PSYCHOTROPIC AGENT; THYROID HORMONE; UNINDEXED DRUG; VASODILATOR AGENT; VITAMIN D;

AGED; ARTICLE; CANADA; CANCER PATIENT; DISEASE SEVERITY; DRUG ABUSE; ELDERLY CARE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; POLYPHARMACY; PRIORITY JOURNAL; PROSPECTIVE STUDY; UNSPECIFIED SIDE EFFECT;

ADVERSE DRUG REACTION REPORTING SYSTEMS; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CANADA; DRUG INTERACTIONS; FEMALE; HOSPITALS, GENERAL; HUMANS; MALE; NEOPLASMS; PILOT PROJECTS; POLYPHARMACY; PROSPECTIVE STUDIES;

EID: 67749134071     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/00002512-200926060-00008     Document Type: Article

References (56)

1. Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet 2007; 370 (9582): 185-91
2. Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet 2007; 370 (9582): 173-84
3. Lindblad CI, Hanlon JT, Gross CR, et al. Clinically important drug-disease interactions and their prevalence in older adults. Clin Ther 2006; 28 (8): 1133-43
4. Hanlon JT, Pieper CF, Hajjar ER, et al. Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay. J Gerontol A Biol Sci Med Sci 2006; 61 (5): 511-5
5. Bowie MW, Slattum PW. Pharmacodynamics in older adults: a review. Am J Geriatr Pharmacother 2007; 5 (3): 263-303
6. Viktil KK, Blix HS, Moger TA, et al. Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacol 2007; 63 (2): 187-95
7. Fick DM, Mion LC, Beers MH, et al. Health outcomes associated with potentially inappropriate medication use in older adults. Res Nurs Health 2008; 31 (1): 42-51
8. Steinman MA, Landefeld CS, Rosenthal GE, et al. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc 2006; 54 (10): 1516-23
9. Page RL, Ruscin JM. The risk of adverse drug events and hospital-related morbidity and mortality among older adults with potentially inappropriate medication use. Am J Geriatr Pharmacother 2006; 4 (4): 297-305
10. Jano E, Aparasu RR. Healthcare outcomes associated with Beers' criteria: a systematic review. Ann Pharmacother 2007; 41 (3): 438-47
11. Pugh MJ, Hanlon JT, Zeber JE, et al. Assessing potentially inappropriate prescribing in the elderly Veterans Affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm 2006; 12 (7): 537-45
12. Tulner LR, Frankfort SV, Gijsen GJ, et al. Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance. Drugs Aging 2008; 25 (4): 343-55
13. Gurwitz JH, Field TS, Harrold LR, et al. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA 2003; 289 (9): 1107-16
14. Fu AZ, Jiang JZ, Reeves JH, et al. Potentially inappropriate medication use and healthcare expenditures in the US community-dwelling elderly. Med Care 2007; 45 (5): 472-6
15. Schmader KE, Hanlon JT, Pieper CF, et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med 2004; 116 (6): 394-401
16. Pugh MJ, Rosen AK, Montez-Rath M, et al. Potentially inappropriate prescribing for the elderly: effects of geriatric care at the patient and health care system level. Med Care 2008; 46 (2): 167-73
17. Canadian cancer statistics 2008. Toronto (ON): Canadian Cancer Society/National Cancer Institute of Canada, 2008
18. Blower P, de Wit R, Goodin S, et al. Drug-drug interactions in oncology: why are they important and can they be minimized? Crit Rev Oncol Hematol 2005; 55 (2): 117-42
19. Sokol KC, Knudsen JF, Li MM. Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side-effect management. J Clin Pharm Ther 2007; 32 (2): 169-75
20. Riechelmann RP, Moreira F, Smaletz O, et al. Potential for drug interactions in hospitalized cancer patients. Cancer Chemother Pharmacol 2005; 56 (3): 286-90
21. Riechelmann RP, Saad ED. A systematic review on drug interactions in oncology. Cancer Invest 2006; 24 (7): 704-12
22. Riechelmann RP, Tannock IF, Wang L, et al. Potential drug interactions and duplicate prescriptions among cancer patients. J Natl Cancer Inst 2007; 99 (8): 592-600
23. Riechelmann RP. Drug combinations with the potential to interact among cancer patients. Support Care Cancer 2007; 15 (9): 1113-4
24. Riechelmann RP, Zimmermann C, Chin SN, et al. Potential drug interactions in cancer patients receiving supportive care exclusively. J Pain Symptom Manage 2008; 35 (5): 535-43
25. Tam-McDevitt J. Polypharmacy, aging, and cancer. Oncology (Williston Park) 2008; 22 (9): 1052-5
26. Bierman AS, Pugh MJ, Dhalla I, et al. Sex differences in inappropriate prescribing among elderly veterans. Am J Geriatr Pharmacother 2007; 5 (2): 147-61
27. Murray MD, Morrow DG, Weiner M, et al. A conceptual framework to study medication adherence in older adults. Am J Geriatr Pharmacother 2004; 2 (1): 36-43
28. Roth MT, Ivey JL. Self-reported medication use in community-residing older adults: a pilot study. Am J Geriatr Pharmacother 2005; 3 (3): 196-204
29. Groll DL, To T, Bombardier C, et al. The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol 2005; 58 (6): 595-602
30. Groll DL, Heyland DK, Caeser M, et al. Assessment of long-term physical function in acute respiratory distress syndrome (ARDS) patients: comparison of the Charlson Comorbidity Index and the Functional Comorbidity Index. Am J Phys Med Rehabil 2006; 85 (7): 574-81
31. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56 (3): M146-56
32. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85 (5): 365-76
33. Perera S, Mody SH, Woodman RC, et al. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc 2006; 54 (5): 743-9
34. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994; 49 (2): M85-94
35. Studenski S, Perera S, Wallace D, et al. Physical performance measures in the clinical setting. J Am Geriatr Soc 2003; 51 (3): 314-22
36. Rantanen T, Guralnik JM, Foley D, et al. Midlife hand grip strength as a predictor of old age disability. JAMA 1999; 281 (6): 558-60
37. Rantanen T, Harris T, Leveille SG, et al. Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol A Biol Sci Med Sci 2000; 55 (3): M168-73
38. Newman AB, Kupelian V, Visser M, et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 2006; 61 (1): 72-7
39. Davis HS, MacPherson K, Merry HR, et al. Reliability and validity of questions about exercise in the Canadian Study of Health and Aging. Int Psychogeriatr 2001; 13 Suppl. 1: 177-82
40. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state': a practical method for grading the cognitive state of patients for the clinician. J Psychiatry Res 1975; 12 (3): 189-98
41. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005; 53 (4): 695-9
42. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983; 67 (6): 361-70
43. Herrmann C. International experiences with the Hospital Anxiety and Depression Scale: a review of validation data and clinical results. J Psychosom Res 1997; 42 (1): 17-41
44. Fillenbaum GG, Smyer MA. The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 1981; 36 (4): 428-34
45. Katz S. Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 1983; 31 (12): 721-7
46. Barat I, Andreasen F, Damsgaard EM. The consumption of drugs by 75-year-old individuals living in their own homes. Eur J Clin Pharmacol 2000; 56 (6-7): 501-9
47. Yourman L, Concato J, Agostini JV. Use of computer decision support interventions to improve medication prescribing in older adults: a systematic review. Am J Geriatr Pharmacother 2008; 6 (2): 119-29
48. Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review. Arch Intern Med 2003; 163 (12): 1409-16
49. Kaufman DW, Kelly JP, Rosenberg L, et al. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 2002; 287 (3): 337-44
50. Hanigan MH, Dela Cruz BL, Thompson DM, et al. Use of prescription and nonprescription medications and supplements by cancer patients during chemotherapy: questionnaire validation. J Oncol Pharm Pract 2008; 14 (3): 123-30
51. Markman M. Safety issues in using complementary and alternative medicine. J Clin Oncol 2002; 20 (18 Suppl.): 39S-41S
52. Schlenk EA, Dunbar-Jacob J, Engberg S. Medication nonadherence among older adults: a review of strategies and interventions for improvement. J Gerontol Nurs 2004; 30 (7): 33-43
53. Partridge AH, Avorn J, Wang PS, et al. Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst 2002; 94 (9): 652-61
54. Partridge AH, Wang PS, Winer EP, et al. Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J Clin Oncol 2003; 21 (4): 602-6
55. Partridge AH, LaFountain A, Mayer E, et al. Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer. J Clin Oncol 2008; 26 (4): 556-62
56. McCowan C, Shearer J, Donnan PT, et al. Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer. Br J Cancer 2008; 99 (11): 1763-8