Direct kinetic evidence that lysine 215 is involved in the phospho-transfer step of human 3-phosphoglycerate kinase

Biochemistry

Volumn 48, Issue 29, 2009, Pages 6998-7008

  Varga, Andrea ^a   Lionne, Corinne ^b   Lallemand, Perrine ^b   Szabó, Judit ^a   Adamek, Nancy ^c   Valentin, Christian ^b   Vas, Mária ^a   Barman, Tom ^b   Chaloin, Laurent ^b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b University of Montpellier I and II   (France)

^c UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3-PHOSPHOGLYCERATE; ACTIVE SITE; ANTI-CANCER THERAPIES; CATALYTIC ROLE; KEY ENZYMES; KINETIC EVIDENCE; KINETIC STUDY; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR MODELING STUDIES; NUCLEOTIDE ANALOGUES; PHOSPHO GROUP; PHOSPHO-TRANSFER; PHOSPHOTRANSFERASE; PRODUCT FORMATION; PRODUCT RELEASE; RAPID QUENCH; RATE LIMITING; RATE-LIMITING STEPS; REVERSIBLE REACTION; SALT BRIDGES; SAMPLING METHOD; STOPPED-FLOW METHOD; SUBSTRATE BINDING; WILD TYPES;

AMINO ACIDS; ENZYMES; MOLECULAR DYNAMICS;

REACTION KINETICS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ARGININE; ASPARTIC ACID; LYSINE 215; LYSINE DERIVATIVE; PHOSPHOGLYCERATE KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; ISOMERIZATION; KINETICS; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; STEADY STATE;

CATALYTIC DOMAIN; HUMANS; KINETICS; LYSINE; MODELS, MOLECULAR; PHOSPHOGLYCERATE KINASE;

EID: 67749129318     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900396h     Document Type: Article

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