Neural correlates of anxiety in healthy volunteers: A voxel-based morphometry study

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 21, Issue 2, 2009, Pages 199-205

  Spampinato, Maria Vittoria ^a   Wood, Jacqueline N ^b   De Simone, Veronica ^c   Grafman, Jordan ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c HOSPITAL BRITÁNICO DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANXIETY; ARTICLE; BRAIN CORTEX; BRAIN REGION; BRAIN SIZE; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; LIMBIC SYSTEM; MALE; MORPHOMETRICS; NORMAL HUMAN; PERSONALITY; PREFRONTAL CORTEX; PRIORITY JOURNAL; VOLUNTEER;

EID: 67749129243     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.2009.21.2.199     Document Type: Article

References (47)

1. Lang PJ: The cognitive psychophysiology of emotion: fear and anxiety, in Anxiety and the Anxiety Disorders. Edited by Tuma AH, Maser JD. Hillsdale, NJ, Erlbaum, 1985, pp 131-170
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. Washington, DC, American Psychiatric Association, 1994
3. Spielberger CD, Gorsuch RL, Lusbene R, et al: Manual for State-Trait Anxiety Inventory. Palo Alto, Calif, Consulting Psychology Press, 1983
4. Davidson RJ: Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry 2002; 51:68-80
5. Bishop S, Duncan J, Brett M, et al: Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli. Nat Neurosci 2004; 7:184-188 (Pubitemid 38129795)
6. Javanmard M, Shlik J, Kennedy SH, et al: Neuroanatomic correlates of CCK-4-induced panic attacks in healthy humans: a comparison of two time points. Biol Psychiatry 1999; 1:872-882 (Pubitemid 29185478)
7. Grachev ID, Apkarian AV: Anxiety in healthy humans is associated with orbital frontal chemistry. Mol Psychiatry 2000; 5:482-488
8. LeDoux JE: Emotion circuits in the brain. Annu Rev Neurosci 2000; 23:155-184
9. Calder A, Lawrence AD, Young AW: Neuropsychology of fear and loathing. Nat Rev Neurosci 2001; 2:352-363
10. Baxter MG, Murray EA: The amygdala and reward. Nat Rev Neurosci 2002; 3:563-573
11. Ashburner J, Friston KJ: Voxel-based morphometry: the methods. NeuroImage 2000; 11:805-821
12. Bremner JD, Vythilingam M, Vermetten E, et al: MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. Am J Psychiatry 2003; 160:924-932 (Pubitemid 41079578)
13. Bremner JD, Randall P, Scott TM, et al: MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 1995; 152:973-981
14. Fontaine R, Breton G, Dery R, et al: Temporal lobe abnormalities in panic disorder: an MRI study. Biol Psychiatry 1990; 27:304-310 (Pubitemid 20055786)
15. Gilbertson MW, Shenton ME, Kiyoto K, et al: Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 2002; 5:1242-1247 (Pubitemid 35247185)
16. Gurvits TV, Shenton ME, Hokama H, et al: Magnetic resonance imaging study of hippocampal volume in chronic, combat- related posttraumatic stress disorder. Biol Psychiatry 1996; 40:1091-1099 (Pubitemid 26400873)
17. Villarreal G, Hamilton DA, Petropoulos H, et al: Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder. Biol Psychiatry 2002; 52:119-125 (Pubitemid 34756557)
18. Yamasue H, Abe O, Suga M, et al: Gender-Common and -Specific Neuroanatomical Basis of Human Anxiety-Related Personality Traits. Cereb Cortex 2008; 18:46-52 (Pubitemid 350233051)
19. Spielberger CD, Gorsuch RL, Lushene R, et al: State-trait anxiety inventory. Palo Alto, Calif, Consulting Psychologists Press, 1968
20. Good CD, Johnsrude IS, Ashburner J, et al: A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 2001; 14:21-36 (Pubitemid 32552740)
21. Sluming V, Barrick T, Howard M, et al: Voxel-based morphomatry reveals increased gray matter density in Broca's area in male symphony orchestra musicians. NeuroImage 2002; 17:1613-1622 (Pubitemid 35333879)
22. Ashburner J, Csernansky JG, Davatzikos C, et al: Computer-assisted imaging to assess brain structure in healthy and diseased brains. Lancet Neurol 2003; 2:79-88 (Pubitemid 37443328)
23. Bonne O, Brandes, D, Gilboa, D, et al: Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Am J Psychiatry 2001; 158:1248-1251 (Pubitemid 32717698)
24. Wignall EL, Dickson JM, Vaughan P, et al: Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder. Biol Psychiatry 2004; 56:832-836 (Pubitemid 39575456)
25. Reiman EM, Raichle ME, Butler FK, et al: A focal brain abnormality in panic disorder, a severe form of anxiety. Nature 1984; 310:683-685
26. Nordahl TE, Semple C, Gross M: Cerebral glucose metabolic differences in patients with panic disorder. Neuropsychopharmacology 1990; 3:261-272
27. Woodward SH, Kaloupek DG, Streeter CC, et al: Decreased anterior cingulate volume in combat-related PTSD. Biol Psychiatry 2006; 59:582-587
28. Yamasue H, Kasai K, Iwanami A, et al: Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proc Natl Acad Sci U S A 2003; 100:9039-9043 (Pubitemid 36899219)
29. Massana G, Serra-Grabulosa JM, Salgado-Pineda P, et al: Parahippocampal gray matter density in panic disorder: a voxelbased morphometric study. Am J Psychiatry 2003; 160:566-568 (Pubitemid 41094267)
30. Uno H, Tarara R, Else JG, et al: Hippocampal damage associated with prolonged and fatal stress in primates. J Neurosci 1989; 9:1705-1711 (Pubitemid 19146266)
31. Phelps EA, O'Connor KJ, Gatenby JC, et al: Activation of left amygdala to a cognitive representation of fear. Nat Neurosci 2001; 4:437-441
32. Grafman J, Vance SC, Weingartner H, et al: The effects of lateralized frontal lesions on mood regulation. Brain 1986; 109:1127-1148 (Pubitemid 17212982)
33. Rauch SL, Shin LM, Segal E, et al: Selectively reduced regional cortical volumes in post-traumatic stress disorder. Neuroreport 2003; 14:913-916 (Pubitemid 36829763)
34. Phillips ML, Drevets WC, Rauch SL, et al: Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry 2003; 54:501-514
35. Williams LM, Kemp AH, Felmingham K, et al: Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. Neuroimage 2006; 29:347-357 (Pubitemid 43063293)
36. Shin LM, Orr SP, Carson MA, et al: Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch Gen Psychiatry 2004; 61:168-176
37. Shin LM, Wright CI, Cannistraro PA, et al: A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 2005; 62: 273-281
38. Vogt BA, Berger GR, Derbyshire SW: Structural and functional dichotomy of human midcingulate cortex. Eur J Neurosci 2003; 18:3134-3144 (Pubitemid 38021556)
39. Morgan AM, Le Doux JE: Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav Neurosci 1995; 109:681-688
40. Maddock RJ, Buonocore MH, Kile SJ, et al: Brain regions showing increased activation by threat-related words in panic disorder. Neuroreport 2003; 14:325-328
41. Maddock RJ, Garrett AS, Buonocore MH: Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Hum Brain Mapp 2003; 18:30-41
42. Bremner JD, Narayan M, Staib LH, et al: Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 1999; 156: 1787-1795 (Pubitemid 29517573)
43. Tankard CF, Waldstein SR, Siegel EL, et al: Cerebral blood flow and anxiety in older men: an analysis of resting anterior asymmetry and prefrontal regions. Brain Cogn 2003; 52:70-78
44. Fuster JM: The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe, 3rd ed. New York, Raven Press, 1997, pp 172-174
45. Eysenck MW: Anxiety: The Cognitive Perspective. Hove, UK, Lawrence Erlbaum Associates Ltd, 1992, pp 51-77
46. Yamasaki H, LaBar KS, McCarthy G: Dissociable prefrontal brain systems for attention and emotion. Proc Natl Acad Sci U S A 2002; 99:11447-11451 (Pubitemid 34920945)
47. Rickels K, Rynn M: Overview and clinical presentation of generalized anxiety disorder. Psychiatr Clin North Am 2001; 24:1-17 (Pubitemid 32153744)