Synthesis and high-throughput screening of N-acetyl-β-hexosaminidase inhibitor libraries targeting osteoarthritis

Journal of Organic Chemistry

Volumn 69, Issue 19, 2004, Pages 6273-6283

  Liu, Junjie ^a   Numa, Mehdi M D ^a   Liu, Haitian ^a   Huang, Shi Jung ^a   Sears, Pamela ^a   Shikhman, Alexander R ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINES; DISEASE CONTROL; ENZYME INHIBITION; ENZYMES; NITROGEN COMPOUNDS; SCREENING;

C1 NITROGEN IMINOCYCLITOLS; HIGH-THROUGHPUT SCREENING; N-ACETYL-Β-HEXOSAMINIDASES; OSTEOARTHRITIS;

SYNTHESIS (CHEMICAL);

ALDEHYDE DERIVATIVE; ALKYNE DERIVATIVE; BETA N ACETYLHEXOSAMINIDASE; BETA N ACETYLHEXOSAMINIDASE INHIBITOR; C 1 NITROGEN IMINOCYCLITOL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; FRUCTOSE; IMINE; MANNOSAMINE; NITROGEN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; OSTEOARTHRITIS; OXIDATION; REACTION ANALYSIS; REPRODUCIBILITY; STEREOCHEMISTRY; TECHNIQUE;

BETA-N-ACETYLHEXOSAMINIDASE; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; OSTEOARTHRITIS;

EID: 4644279003     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo049355h     Document Type: Article

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