The role of the Val57 amino-acid residue in the hinge loop of the human cystatin C. Conformational studies of the Beta2-L1-Beta3 segments of wild-type human cystatin C and its mutants

Biopolymers

Volumn 91, Issue 5, 2009, Pages 373-383

  Rodziewicz Motowidło, Sylwia ^a   Iwaszkiewicz, Justyna ^a   Sosnowska, Renata ^a   Czaplewska, Paulina ^a   Sobolewski, Emil ^a   Szymańska, Aneta ^a   Stachowiak, Krystyna ^a   Liwo, Adam ^a  

^a UNIVERSITY OF GDA SK   (Poland)

Author keywords

hairpin; Circular dichroism (CD); Hinge loop; Human cystatin C (HCC); Molecular dynamics (MD); Point mutations; Potential of mean force (PMF)

Indexed keywords

CIRCULAR DICHROISM; CIRCULAR DICHROISM (CD); CLOSED FORM; CONFORMATIONAL CHANGE; CONFORMATIONAL STUDY; CYSTATIN; DIMER FORMATION; HUMAN CYSTATIN C (HCC); HYDROPHOBIC POCKETS; PARTIAL UNFOLDING; POINT MUTATIONS; POTENTIAL OF MEAN FORCE (PMF); THREE-DIMENSIONAL DOMAIN SWAPPING; TURN STRUCTURE; WILD TYPES; CYSTATINS; POTENTIAL OF MEAN FORCE;

AMINES; DIMERIZATION; MOLECULAR DYNAMICS; PEPTIDES;

DICHROISM;

ASPARAGINE; ASPARTIC ACID; CYSTATIN C; GLUTAMINE; HISTIDINE; LEUCINE; PROLINE; THREONINE; VALINE; MUTANT PROTEIN; PEPTIDE; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HINGE REGION; HYDROPHOBICITY; MUTANT; OLIGOMERIZATION; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN MODIFICATION; WILD TYPE; BETA HAIRPIN; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN MOTIF; PROTEIN STABILITY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; CYSTATIN C; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; VALINE;

EID: 67749127398     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21140     Document Type: Article

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