Checking the conformational stability of cystatin C and its L68Q variant by molecular dynamics studies: Why is the L68Q variant amyloidogenic?

Journal of Structural Biology

Volumn 154, Issue 1, 2006, Pages 68-78

  Rodziewicz Motowidło, Sylwia ^a   Wahlbom, Maria ^b   Wang, Xin ^b   Ła̧giewka, Justyna ^a   Janowski, Robert ^c,d   Jaskólski, Mariusz ^c,d   Grubb, Anders ^b   Grzonka, Zbigniew ^a  

^a UNIVERSITY OF GDA SK   (Poland)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c ADAM MICKIEWICZ UNIVERSITY   (Poland)

^d INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

Amyloidosis; Conformational change; Human cystatin C; Molecular dynamics simulation; Single point mutation

Indexed keywords

AMYLOID PROTEIN; CYSTATIN C;

ARTICLE; HYDROGEN BOND; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; X RAY;

AMINO ACID SUBSTITUTION; AMYLOID; COMPUTER SIMULATION; CYSTATINS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; SALTS; SOLVENTS;

EID: 33645003090     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2005.11.015     Document Type: Article

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