Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications. Crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid, and benzylhydroxamic acid

Journal of Biological Chemistry

Volumn 284, Issue 30, 2009, Pages 20311-20318

  Singh, Amit K ^a   Singh, Nagendra ^a   Sinha, Mau ^a   Bhushan, Asha ^a   Kaur, Punit ^a   Srinivasan, Alagiri ^a   Sharma, Sujata ^a   Singh, Tej P ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL GROUPS; ACETYL SALICYLIC ACID; ACETYLSALICYLIC ACIDS; AROMATIC LIGANDS; AROMATIC SUBSTRATES; BENZENE RING; BINDING CHARACTERISTICS; BINDING MODES; CARBONYL OXYGEN ATOMS; HEME IRON; HEME MOIETY; HEME PEROXIDASE; HYDROXAMIC ACIDS; HYDROXYL GROUPS; LACTOPEROXIDASE; MECHANISM OF ACTION; OH GROUP; SALICYLHYDROXAMIC ACID; STRUCTURAL STUDIES; SUBSTRATE-BINDING SITES; WATER MOLECULE;

AROMATIC COMPOUNDS; BENZENE; BINDING ENERGY; HEMOGLOBIN; HYDROGEN; HYDROGEN BONDS; IRON COMPOUNDS; LIGANDS; MAMMALS; ORGANIC ACIDS; OXYGEN; PLANTS (BOTANY); PORPHYRINS; SUBSTRATES;

BINDING SITES;

ACETIC ACID DERIVATIVE; ACETYLSALICYLIC ACID; AROMATIC COMPOUND; BENZENE DERIVATIVE; BENZYLHYDROXAMIC ACID; CARBONYL DERIVATIVE; GLUTAMINE; HEME; HISTAMINE; HYDROGEN; HYDROXAMIC ACID DERIVATIVE; HYDROXYL GROUP; IRON; LACTOPEROXIDASE; OXYGEN DERIVATIVE; SALICYLHYDROXAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STRUCTURE ANALYSIS;

ANIMALS; ASPIRIN; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; HEME; HYDROGEN BONDING; HYDROXAMIC ACIDS; LACTOPEROXIDASE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SALICYLAMIDES;

BOVINAE; MAMMALIA;

EID: 67749111837     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.010280     Document Type: Article

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