Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 3845-3851

  Amblard, Franck ^a   Fromentin, Emilie ^a   Detorio, Mervi ^a   Obikhod, Alexander ^a   Rapp, Kimberly L ^a   McBrayer, Tamara R ^b   Whitaker, Tony ^b   Coats, Steven J ^b   Schinazi, Raymond F ^a  

^a EMORY CENTER FOR AIDS RESEARCH   (United States)

^b RFS Pharma LLC   (United States)

Author keywords

Nucleosides; Stability; Tricyclic

Indexed keywords

2' C METHYLGUANOSINE; 3 (BETA DEXTRO 2 CARBOXYMETHYLRIBOFURANOSYL) 3,9 DIHYDRO 6 (4 DIMETHYLAMINOPHENYL) 9 OXO 5H IMIDAZO[1,2 A]PURINE; 3,9 DIHYDRO 9 OXO 5H IMIDAZO[1,2 A]PURINE NUCLEOSIDE DERIVATIVE; 9 [4 ALPHA (HYDROXYMETHYL)CYCLOPENT 2 ENE 1 ALPHA YL]GUANINE; BETA DEXTRO (2,4) 1,3 DIOXOLANE GUANOSINE; NUCLEOSIDE DERIVATIVE; TRICYCLIC NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; EVALUATION RESEARCH; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; HEPACIVIRUS; HERPESVIRUS 1, HUMAN; HIV; HUMANS; NUCLEOSIDES; VERO CELLS;

EID: 67749105985     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.003     Document Type: Article

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