Synthesis of a technetium-99m labeled tricyclic ganciclovir analog for non-invasive reporter gene expression imaging

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 3, 2007, Pages 741-744

  Zhang, Yi ^a   Lin, Jing ^a   Pan, Dongfeng ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

HSV1 TK substrate; Nuclear imaging tracer; Technetium 99m

Indexed keywords

3 [(1,3 DIHYDROXYPROPAN 2 YLOXY)METHYL] 6 [4 [3 [2 MERCAPTOETHYL [2 (2 MERCAPTOETHYLAMINO)ETHYL]AMINO]PROPOXY]PHENYL] 3H IMIDAZOPURIN 9(5H) ONE OXOTECHNETIUM TC 99M; GANCICLOVIR DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; IMAGING; NONHUMAN; RADIOCHEMISTRY; REPORTER GENE;

ANTIMETABOLITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GANCICLOVIR; GENE EXPRESSION; GENES, REPORTER; HERPESVIRUS 1, HUMAN; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TECHNETIUM; THYMIDINE KINASE;

EID: 33846192871     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.077     Document Type: Article

References (23)

1. Yaghoubi S.S., Barrio J.R., Namavari M., Satyamurthy N., Phelps M.E., Herschman H.R., and Gambhir S.S. Cancer Gene Ther. 12 (2005) 329
2. Min J.J., Lyer M., and Gambhir S.S. Eur. J. Nucl. Med. Mol. Imaging 30 (2003) 1547
3. Shah K., Jacobs A., Breakefield X.O., and Weissleder R. Gene Ther. 11 (2004) 1175
4. Lyer M., and Gambhir S.S. Lung Biol. Health Dis. 203 (2005) 171
5. Mercer J.R., Xu L.H., Knaus E.E., and Wiebe L.I. J. Med. Chem. 32 (1989) 1289
6. Tjuvajev J.G., Avril N., Oku T., Sasajima T., Miyagawa T., Joshi R., Safer M., Beattie B., DiResta G., Daghighian F., Augensen F., Koutcher J., Zweit J., Humm J., Larson S.M., Finn R., and Blasberg R. Cancer Res. 58 (1998) 4333
7. Morin K.W., Atrazheva E.D., Knaus E.E., and Wiebe L.I. J. Med. Chem. 40 (1997) 2184
8. Wiebe L.I., Knaus E.E., and Morin K.W. Nucleosides Nucleotides 18 (1999) 1065
9. Tjuvajev J.G., Finn R., Watanabe K., Joshi R., Oku T., Kennedy J., Beattie B., Koutcher J., Larson S., and Blasberg R.G. Cancer Res. 56 (1996) 4087
10. Alauddin M.M., Shahinian A., Kundu R.K., Gordon E.M., and Conti P.S. Nucl. Med. Biol. 26 (1999) 371
11. Alauddin M.M., and Conti P.S. Nucl. Med. Biol. 25 (1998) 175
12. Goslinski T., Golankiewicz B., De Clercq E., and Balzarini J. J. Med. Chem. 45 (2002) 5052
13. Golankiewicz B., Ostrowski T., Andrei G., Snoeck R., and De Clercq E. J. Med. Chem. 37 (1994) 3187
14. Goslinski T., Wenska G., Golankiewicz B., Balzarini J., and De Clercq E. Nucleosides Nucleotides Nucleic Acids 22 (2003) 911
15. + (theorectcal m/z 791.2).
16. 7 requires 512.2140).
17. 6 requires 482.2034).
18. 5 requires 412.1615).
19. 2 requires 641.2077).
20. Zhang Y., Dai X., Kallmes D.F., and Pan D. Tetrahedron Lett. 45 (2004) 8673
21. 2 requires 521.2502).
22. 2 requires 579.2921).
23. 2 requires 1072.4882).