The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated byphosphorylation

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19290-19300

  Cohen Gonsaud, Martin ^a,b,c   Barthe, Philippe ^a,b,c   Canova, Marc J ^d   Stagier Simon, Charlotte ^a,b,c   Kremer, Laurent ^e   Roumestand, Christian ^a,b,c   Molle, Virginie ^d  

^a CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^b INSERM   (France)

^c UNIV MONTPELLIER   (France)

^d UNIVERSITÉ LYON 1   (France)

^e UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL WALLS; DNA-BINDING; DNA-BINDING PROTEIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENCE ANISOTROPY; HELIX-TURN-HELIX MOTIFS; KINASE SUBSTRATES; M. TUBERCULOSIS; MALDI-TOF; MASS SPECTROMETRY ANALYSIS; MULTIDIMENSIONAL NMR; MYCOBACTERIUM TUBERCULOSIS; N-TERMINAL; N-TERMINAL EXTENSION; PROTEIN KINASE; SOLUTION STRUCTURES;

BINDING SITES; CELL MEMBRANES; DNA; ELECTROPHORETIC MOBILITY; GENES; MASS SPECTROMETRY; NUCLEIC ACIDS; PHOSPHORYLATION; PROTEINS;

SUBSTRATES;

DNA BINDING PROTEIN; PROTEIN RV2175C; PROTEIN SERINE THREONINE KINASE; THREONINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; ENZYME SUBSTRATE; MOLECULAR MECHANICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CHROMATOGRAPHY, LIQUID; CLONING, MOLECULAR; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENCE POLARIZATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

ACTINOBACTERIA (CLASS); MYCOBACTERIUM TUBERCULOSIS;

EID: 67749099836     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.019653     Document Type: Article

References (38)

1. Stock, J. B., Ninfa, A. J., and Stock, A. M. (1989) Microbiol. Rev. 53, 450-490
2. Hanks, S. K., Quinn, A. M., and Hunter, T. (1988) Science 241, 42-52
3. Hunter, T. (1995) Cell 80, 225-236
4. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., 3rd, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M. A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., and Barrell, B. G. (1998) Nature 393, 537-544
5. Av-Gay, Y., and Everett, M. (2000) Trends Microbiol. 8, 238-244
6. Wehenkel, A., Bellinzoni, M., Graña, M., Duran, R., Villarino, A., Fernandez, P., Andre-Leroux, G., England, P., Takiff, H., Cerveñansky, C., Cole, S. T., and Alzari, P. M. (2008) Biochim. Biophys. Acta 1784, 193-202
7. Sharma, K., Gupta, M., Krupa, A., Srinivasan, N., and Singh, Y. (2006) FEBS J. 273, 2711-2721
8. Molle, V., Brown, A. K., Besra, G. S., Cozzone, A. J., and Kremer, L. (2006) J. Biol. Chem. 281, 30094-30103
9. Veyron-Churlet, R., Molle, V., Taylor, R. C., Brown, A. K., Besra, G. S., Zanella-Cléon, I., Fütterer, K., and Kremer, L. (2009) J. Biol. Chem. 284, 6414-6424
10. O'Hare, H. M., Durán, R., Cerveñansky, C., Bellinzoni, M., Wehenkel, A. M., Pritsch, O., Obal, G., Baumgartner, J., Vialaret, J., Johnsson, K., and Alzari, P. M. (2008) Mol. Microbiol. 70, 1408-1423
11. Villarino, A., Duran, R., Wehenkel, A., Fernandez, P., England, P., Brodin, P., Cole, S. T., Zimny-Arndt, U., Jungblut, P. R., Cerveñansky, C., and Alzari, P. M. (2005) J. Mol. Biol. 350, 953-963
12. Dasgupta, A., Datta, P., Kundu, M., and Basu, J. (2006) Microbiology 152, 493-504
13. Kang, C. M., Nyayapathy, S., Lee, J. Y., Suh, J. W., and Husson, R. N. (2008) Microbiology 154, 725-735
14. Greenstein, A. E., MacGurn, J. A., Baer, C. E., Falick, A. M., Cox, J. S., and Alber, T. (2007) PLoS Pathog. 3, e49
15. Park, S. T., Kang, C. M., and Husson, R. N. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 13105-13110
16. Canova, M. J., Kremer, L., and Molle, V. (2009) J. Bacteriol. 191, 2876-2883
17. Canova, M. J., Veyron-Churlet, R., Zanella-Cleon, I., Cohen-Gonsaud, M., Cozzone, A. J., Becchi, M., Kremer, L., and Molle, V. (2008) Proteomics 8, 521-533
18. Narayan, A., Sachdeva, P., Sharma, K., Saini, A. K., Tyagi, A. K., and Singh, Y. (2007) Physiol. Genomics 29, 66-75
19. Cohen-Gonsaud, M., Barthe, P., Pommier, F., Harris, R., Driscoll, P. C., Keep, N. H., and Roumestand, C. (2004) J. Biomol. NMR 30, 373-374
20. Canova, M. J., Kremer, L., and Molle, V. (2008) Plasmid 60, 149-153
21. Barthe, P., Roumestand, C., Canova, M. J., Kremer, L., Hurard, C., Molle, V., and Cohen-Gonsaud, M. (2009) Structure 17, 568-578
22. Sattler, M., Schleucher, J., and Griesinger, C. (1999) Prog. NMR Spectrosc. 34, 93-158
23. Pons, J. L., Malliavin, T. E., and Delsuc, M. A. (1996) J. Biomol. NMR 8, 445-452
24. Güntert, P. (2004) Methods Mol. Biol. 278, 353-378
25. Cornilescu, G., Delaglio, F., and Bax, A. (1999) J. Biomol. NMR 13, 289-302
26. Nederveen, A. J., Doreleijers, J. F., Vranken, W., Miller, Z., Spronk, C. A., Nabuurs, S. B., Güntert, P., Livny, M., Markley, J. L., Nilges, M., Ulrich, E. L., Kaptein, R., and Bonvin, A. M. (2005) Proteins 59, 662-672
27. Laskowski, R. A., Moss, D. S., and Thornton, J. M. (1993) J. Mol. Biol. 231, 1049-1067
28. Koradi, R., Billeter, M., and Wuthrich, K. (1996) J. Mol. Graph. 14, 51-55, 29-32
29. Fiuza, M., Canova, M. J., Zanella-Cléon, I., Becchi, M., Cozzone, A. J., Mateos, L. M., Kremer, L., Gil, J. A., and Molle, V. (2008) J. Biol. Chem. 283, 18099-18112
30. Aravind, L., Anantharaman, V., Balaji, S., Babu, M. M., and Iyer, L. M. (2005) FEMS Microbiol. Rev. 29, 231-262
31. Sam, M. D., Cascio, D., Johnson, R. C., and Clubb, R. T. (2004) J. Mol. Biol. 338, 229-240
32. Cottin, V., Van Linden, A., and Riches, D. W. (1999) J. Biol. Chem. 274, 32975-32987
33. Garvie, C. W., and Wolberger, C. (2001) Mol. Cell 8, 937-946
34. Kang, C. M., Abbott, D. W., Park, S. T., Dascher, C. C., Cantley, L. C., and Husson, R. N. (2005) Genes Dev. 19, 1692-1704
35. Molle, V., Kremer, L., Girard-Blanc, C., Besra, G. S., Cozzone, A. J., and Prost, J. F. (2003) Biochemistry 42, 15300-15309
36. Alderwick, L. J., Molle, V., Kremer, L., Cozzone, A. J., Dafforn, T. R., Besra, G. S., and Fütterer, K. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 2558-2563
37. Sharma, K., Gupta, M., Pathak, M., Gupta, N., Koul, A., Sarangi, S., Baweja, R., and Singh, Y. (2006) J. Bacteriol. 188, 2936-2944
38. Kumar, P., Kumar, D., Parikh, A., Rananaware, D., Gupta, M., Singh, Y., and Nandicoori, V. K. (2009) J. Biol. Chem. 284, 11090-11099