Venous thromboembolism and ethnicity

British Journal of Haematology

Volumn 146, Issue 4, 2009, Pages 369-383

  Roberts, Lara N ^a   Patel, Raj K ^a   Arya, Roopen ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Deep vein thrombosis; Ethnicity; Pulmonary embolism; Race; Venous thromboembolism

Indexed keywords

ASIAN; CAUCASIAN; ETHNIC DIFFERENCE; ETHNICITY; GENETIC DISORDER; HUMAN; NEGRO; PREVALENCE; PRIORITY JOURNAL; REVIEW; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

ANTICOAGULANTS; CONTINENTAL POPULATION GROUPS; ETHNIC GROUPS; FEMALE; HUMANS; MALE; PREGNANCY; PREVALENCE; RECURRENCE; RISK; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM;

EID: 67749091044     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07786.x     Document Type: Review

References (119)

1. Anderson, F.A., Wheeler, H.B., Goldberg, R.J., Hosmer, D.W., Patwardan, N.A., Jovanovic, B., Forcier, A. Dalen, J.E. (1991) A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. Archives of Internal Medicine, 151, 933 938.
2. Andrew, M., David, M., Adams, M., Ali, K., Anderson, R., Barnard, D., Bernstein, M., Brisson, L., Cairney, B. DeSai, D. (1994) Venous thromboembolic complications (VTE) in children: first analyses of the Canadian registry for VTE. Blood, 83, 1251 1257.
3. Atichartakarn, V., Pathepchotiwong, K., Keorochana, N. Eurvilaichit, C. (1988) Deep vein thrombosis after hip surgery among Thai. Archives of Internal Medicine, 148, 1349 1353.
4. Aujesky, D., Long, J.A., Fine, M.J. Ibrahim, S.A. (2007) African American race is associated with an increased risk of complications following venous thromboembolism. Journal of Clinical Epidemiology, 60, 410 416.
5. Austin, H., Hooper, W.C., Lally, C., Dilley, A., Ellingsen, D., Wideman, C., Wenger, N.K., Rawlins, P., Silva, V. Evatt, B. (2000) Venous thrombosis in relation to fibrinogen and Factor VII genes among African-Americans. Journal of Clinical Epidemiology, 53, 997 1001.
6. Awidi, A., Shannak, M., Bseiso, A., Kailani, M.A.M., Kailani, M.A., Omar, N., Anshasi, B. Sarkarneh, N. (1999) High prevalence of Factor V Leiden in healthy Jordanians. Thrombosis and Haemostasis, 81, 582 584.
7. Baglin, T., Luddington, R., Brown, K. Baglin, C. (2004) The risk of recurrent venous thromboembolism is higher in men. Journal of Thrombosis and Haemostasis, 2, 2152 2155.
8. Bombeli, T., Basic, A. Fehr, J. (2001) Prevalence of hereditary thrombophilia in patients with venous thrombosis in different venous systems. American Journal of Hematology, 70, 126 132.
9. Bournemaux, H., Hicklin, L. Desmarais, S. (1996) Seasonal variation in deep vein thrombosis. British Medical Journal, 312, 284 285.
10. Burchard, E.G., Ziv, E., Coyle, N., Gomez, S.L., Tang, H., Karter, A.J., Mountain, J.L., Perez-Stable, E.J., Sheppard, D. Risch, N. (2003) The importance of race and ethnic background in biomedical research and clinical practice. New England Journal of Medicine, 348, 1170 1175.
11. Cavalli-Sforza, L.L., Menozzi, P. Amd Piazza, A. (1994) The History and Geography of Human Genes. Princeton University Press, Princeton, USA.
12. Chan, L.Y., Tam, W.H. Lau, T.K. (2001) Venous thromboembolism in pregnant Chinese women. Obstetrics and Gynaecology, 98, 471 475.
13. Chau, K.Y., Yuen, S.T. Wong, M.P. (1997) Clinicopathological pattern of pulmonary thromboembolism in Chinese autopsy patients: comparison with Caucasian series. Pathology, 29, 263 266.
14. Cheuk, B.L.Y., Cheung, G.C.Y. Cheng, S.W.K. (2004) Epidemiology of venous thromboembolism in a Chinese population. British Journal of Surgery, 91, 424 428.
15. Chew, H.K., Wun, T., Harvey, D., Zhou, H. White, R.H. (2006) Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Archives of Internal Medicine, 166, 458 464. (Pubitemid 43313651)
16. Cook, D.G., Cappuccino, F.P., Atkinson, R.W., Wicks, P.D., Chitolie, A., Nakandakare, E.R., Sagnella, G.A. Humphries, S.E. (2001) Ethnic differences in fibrinogen levels: the role of environmental factors and the β-fibrinogen gene. American Journal of Epidemiology, 153, 799 806.
17. Cunningham, I.G.E. Yong, N.K. (1974) The incidence of post operative venous thromboembolism in Malaysia. British Journal of Surgery, 61, 482 483.
18. Danckwardt, S., Hartmann, K., Katz, B., Hentze, M.W., Levy, Y., Eichele, R., Deutsch, V., Kulozik, A.E. Ben-Tal, O. (2006) The prothrombin 20209 C→T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3′ end processing. Journal of Thrombosis and Haemostasis, 4, 1078 1085.
19. Dang, M.T., Hambledon, J. Kayser, S.R. (2005) The influence of ethnicity on warfarin dose requirement. Annals of Pharmacotherapy, 39, 1008 1012.
20. De Silva, D.A., Pey, H.B., Wong, M.C., Chang, H.M. Chen, C.P.L.H. (2006) Deep vein thrombosis following ischaemic stroke among Asians. Cerebrovascular Diseases, 22, 245 250.
21. Dexter, L. Folch-Pi, W. (1974) Venous thrombosis. An account of the first documented case. Journal of the American Medical Association, 228, 592 597.
22. Dilley, A., Austin, H., Hooper, W.C., El-Jamil, M., Whitsett, C., Wenger, N.K., Benson, J. Evatt, B. (1998) Prevalence of the prothrombin 20210 G-to-A variant in blacks; Infants, patients with venous thrombosis, patients with myocardial infarction and control subjects. Journal of Laboratory and Clinical Medicine, 132, 452 455.
23. Dowling, N.F., Austin, H., Dilley, H., Whitsett, C., Evatt, B.L. Hooper, W.C. (2003) The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE study. Journal of Thrombosis and Haemostasis, 1, 80 87.
24. Eichinger, S., Minar, E., Bialonczyk, C., Hirschl, M., Quehenberger, P., Schneider, B., Weltermann, A., Wagner, O. Kyrle, P.A. (2003) D-dimer levels and risk of recurrent venous thromboembolism. Journal of the American Medical Association, 20, 1071 1074. (Pubitemid 37430448)
25. Eid, S.S. (2002) Hereditary deficiencies of antithrombin III, protein S and the protein C pathway in Jordanian patients with thrombosis. Clinical Laboratory Science, 15, 196 199.
26. Folsom, A.R., Wu, K.K., Davies, C.E., Conlan, M.G., Sorlie, P.D. Szklo, M. (1991) Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Atherosclerosis, 91, 191 205.
27. Folsom, A.R., Qamhieh, H.T., Flack, J.M., Hilner, J.E., Liu, K., Howard, B.V. Tracy, R.P. for the investigators of coronary artery risk development in young adults (CARIDA) study 1993) Plasma fibrinogen: levels and correlates in young adults. American Journal of Clinical Epidemiology, 138, 1023 1036.
28. Fong, Y.K., Ruban, P., Yeo, S.J., Lee, B.P.H., Lo, N.N., Seow, K.H. Ng, S.C.K. (2000) Use of low molecular weight heparin for prevention of deep vein thrombosis in total knee arthroscopy - a study of its efficacy in the Asian population. Annals Academy of Medicine Singapore, 29, 439 441.
29. Franco, R.F. Reitsma, P.H. (2001) Genetic risk factors of venous thrombosis. Human Genetics, 109, 369 384.
30. Franco, R.F., Santos, S.E.B., Elion, J., Tavella, M.H. Zago, M.A. (1998) Prevalence of the G20210A polymorphism in the 3′-untranslated region of the prothrombin gene in different human populations. Acta Haematologica, 100, 9 12.
31. Garewal, G., Das, R., Varma, S., Chawla, Y. Prabhaker, S. (2003) Heterogenous distribution of Factor V Leiden in patients from North India with venous thromboembolism. Journal of Thrombosis and Haemostasis, 1, 1329 1331.
32. Geerts, W.H., Pineo, G.F., Heit, J.A., Bergqvist, D., Lassen, M.R., Colwell, C.W. Ray, J.R. (2004) Prevention of venous thromboembolism: the Seventh ACCP Conference on Anithrombotic and Thrombolytic Therapy. Chest, 126, 338S 400S.
33. Gillum, R.F. (1987) Pulmonary embolism and thrombophlebitis in the United States, 1970-1985. American Heart Journal, 114, 1262 1264.
34. Goldstein, D.B., Tate, S.K. Sisodiya, S.M. (2003) Pharmacogenetics goes genomic. Nature Reviews Genetics, 4, 937 947.
35. Gore, I., Hirst, A.E. Tanaka, K. (1964) Myocardial infarction and thromboembolism. Archives of Internal Medicine, 113, 323 330.
36. Hansson, P.O., Sorbo, J. Eriksson, H. (2000) Recurrent venous thromboembolism after deep vein thrombosis. Archives of Internal Medicine, 160, 769 774.
37. Hassan, M.A., Rahman, E.A. Rahman, I.A. (1973) Postoperative deep vein thrombosis in Sudanese patients. British Journal of Surgery, 1, 515 517.
38. Heit, J.A., Mohr, D.N., Silverstein, M.D., Petterson, T.M., O'Fallon, W.M. Melton, L.J. (2000) Predictors of recurrence after deep vein thrombosis and pulmonary embolism. Archive of Internal Medicine, 160, 761 768.
39. Heit, J.A., O'Fallon, M., Petterson, T.M., Lohse, C.M., Silverstein, M.D., Mohr, D.N. Melton, J. (2002) Relative impact of risk factors for deep vein thrombosis and pulmonary embolism. Archives of Internal Medicine, 162, 1245 1248.
40. Heit, J.A., Cobbervig, C.E., James, A.H., Petterson, T.M., Bailey, K.R. Melton, L.J. (2005) Trends in the incidence of venous thromboembolism during pregnancy or post-partum: a 30 year population-based study. Annals of Internal Medicine, 143, 697 705.
41. House of Commons Health Committee 2005) The prevention of venous thromboembolism in hospitalised patients (Second report of session 2004-2005). The Stationary Office, London. Available at: http://www.publications.parliament. uk/pa/cm200405/cmselect/cmhealth/99/99.pdf.
42. Irani-Hakime, N., Tamim, H., Elias, G., Finan, R.R., Daccache, J.L. Almawi, W.M. (2000) High prevalence of factor V mutation (Leiden) in the Eastern Mediterranean. Clinical Chemistry, 46, 134 136.
43. Itakura, H. (2005) Racial disparities in risk factors for thrombosis. Current Opinion in Hematology, 12, 364 369.
44. Jain, V., Dhaon, B.K., Jaiswal, A., Nigam, V. Singla, J. (2004) Deep vein thrombosis after total hip and knee replacement in Indian patients. Postgraduate Medical Journal, 80, 729 731.
45. Jerrard-Dunne, P., Evans, A., McGovern, R., Hajat, C., Kalra, L., Rudd, A.G., Wolfe, C.D. Markus, H.S. (2003) Ethnic differences in markers of thrombophilia. Stroke, 34, 1821 1827.
46. Joffe, S.N. (1974) Racial incidence of post-operative deep vein thrombosis in South Africa. British Journal of Surgery, 61, 982 983.
47. Kearon, C., Ginsberg, J.S., Douketis, J., Crowther, M., Brill-Edwards, P., Weitz, J.I. Hirsh, J. (2001) Management of suspected deep venous thromboembolism in outpatients by using clinical assessment and D-dimer testing. Annals of Internal Medicine, 135, 108 111.
48. Keenan, C.R. White, R.H. (2007) The effects of race/ethnicity and sex on the risk of venous thromboembolism. Current Opinion Pulmonary Medicine, 13, 377 383.
49. Klatsky, A.L., Armstrong, M.A. Poggi, J. (2000) Risk of pulmonary embolism and/or deep venous thrombosis in Asian-Americans. American Journal of Cardiology, 85, 1334 1337.
50. Koster, T., Blann, A.D., Briet, E., Vandenbroucke, J.P. Rosendaal, F.R. (1995) Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet, 345, 152 155.
51. Kraaijenhagen, R.A., in't Anker, P.S., Koopman, M.M.W., Reitsma, P.H., Prins, M.H., van den Ende, A. Buller, H.R. (2000) High plasma concentration of Factor VIIIc is a major risk factor for venous thromboembolism. Thrombosis and Haemostasis, 83, 5 9.
52. Kyrle, P.A., Minar, E., Hirschl, M., Bialonczyk, C., Stain, M., Schneider, B., Weltermann, A., Speiser, W., Lechner, K. Eichinger, S. (2000) High plasma levels of Factor VIII and the risk of recurrent venous thromboembolism. New England Journal of Medicine, 343, 457 462. (Pubitemid 30646484)
53. Kyrle, P.A., Minar, E., Bialonczyk, C., Hirschl, M., Welterman, A. Eichinger, S. (2004) The risk of recurrent venous thromboembolism in men and women. New England Journal of Medicine, 350, 2558 2563.
54. Lee, A.C.W., Lee, C.H., Szeto, S.C. Ma, E.S.K. (2003) Symptomatic venous thromboembolism in Chinese children. Hong Kong Medical Journal, 9, 259 262.
55. Leizorovicz, A., Turpie, A.G.G., Cohen, A.T., Dhillon, K.S., Anychaisuksiri, P. Wang, C.J., for the SMART Study Group 2004) Epidemiology of post-operative venous thromboembolism in Asian countries. International Journal of Angiology, 5, 68 72.
56. Leizorovicz, A., Turpie, A.G.G., Cohen, A.T., Wong, L., Yoo, M.C. Dans, A. For the SMART study group 2005) Epidemiology of venous thromboembolism in Asian patients undergoing major orthopaedic surgery without thromboprophylaxis. Journal of Thrombosis and Haemostasis, 3, 28 34.
57. Leung, V., Leung, V., Lui, W., Chan, T., Wong, R.S.M. Cheng, G. (2006) Incidence of deep vein thrombosis in hospitalised Chinese medical patients is similar to that in Western populations. Thrombosis Research, 118, 763 764.
58. Lucotte, G. Mercier, G. (2001) Population genetics of Factor V Leiden in Europe. Blood Cells, Molecules, and Diseases, 27, 362 367.
59. Mannucci, P. (2001) Historical review: venous thrombosis and anticoagulant therapy. British Journal of Haematology, 114, 258 270.
60. Miyata, T., Kimura, R., Kokuba, Y. Sakata, T. (2006) Genetic risk factors for deep vein thrombosis among Japanese: importance of Protein S K196E mutation. International Journal of Hematology, 83, 217 223. (Pubitemid 44227995)
61. Murin, S., Marelich, G.P., Arroliga, A.C. Matthay, R.A. (1998) Hereditary thrombophilia and venous thromboembolism. American Journal of Respiratory and Critical Care Medicine, 158, 1369 1373.
62. Nakamura, M., Fujioka, H., Yamada, N., Sakuma, M., Okada, O., Nakanishi, N., Miyahara, Y., Kuriyama, T., Kuneida, T., Sugimoto, T. Nakano, T. (2001) Clinical characteristics of acute pulmonary thromboembolism in Japan: results of a multi-centre registry in the Japanese Society of Pulmonary Embolism Research. Clinical Cardiology, 24, 132 138.
63. Nossent, J.C. Egelie, N.C.W.M. (1993) Incidence and course of symptomatic deep vein thrombosis of the lower extremeties in a black Caribbean population. Journal of Thrombosis and Haemostasis, 70, 576 578.
64. Oh, S.Y., Kim, J.H., Lee, K.W., Bang, S.M., Hwang, J.H., Oh, D. Lee, J.S. (2008) Venous thromboembolism in patients with pancreatic adenocarcinoma: lower incidence in Asian ethnicity. Thrombosis Research, 122, 485 490.
65. van Ommen, C.H., Heijboer, H., Buller, H.R., Hersing, R.A., Heijmans, H.S.A. Peters, M. (2001) Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. Journal of Pediatrics, 139, 676 681.
66. Palareti, G., Legnani, C., Cosmi, B., Guazzoloca, G., Pancani, C. Coccheri, S. (2002) Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after anticoagulation is stopped. Thrombosis and Haemostasis, 87, 7 12.
67. Patel, R.K. Arya, R. (2008) Venous thromboembolism: racial and ethnic influences. Therapy, 5, 169 175.
68. Patel, R.K., Ford, E., Thumpston, J. Arya, R. (2003) Risk factors for venous thrombosis in the black population. Thrombosis and Haemostasis, 90, 835 838.
69. Patel, R.K., Ford, E., Thumpton, J. Arya, R. (2004) Coagulation factor levels and venous thrombosis in the black population. Thrombosis and Haemostasis, 91, 828 830.
70. Peng, Y.-Y., Jeng, J.S., Shen, M.-C., Tsay, W., Wang, B.-S., Lin, W.-H., Chang, Y.-C. Yip, P.-K. (1998) Aetiologies and prognosis of Chinese patients with deep vein thrombosis of the lower extremities. Quarterly Journal of Medicine, 91, 681 686.
71. Pepe, G., Rickards, O., Vanegas, O.C., Brunelli, T., Gori, A.M., Giusti, B., Attanasio, M., Prisco, D., Gensini, G.F. Abbate, R. (1997) Prevalence of Factor V Leiden mutation in Non-European populations. Thrombosis and Haemostasis, 77, 329 331.
72. Peyvandi, F., Spreafico, M., Siboni, S.M., Moia, M. Mannucci, P.M. (2004) CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy. Clinical Pharmacology and Therapeutics, 75, 198 203.
73. Pieper, C.F., Rao, K.M.K., Currie, M.S., Harris, T.B. Cohen, H.J. (2000) Age, functional status, and racial differences in plasma D-dimers in community dwelling elderly persons. Journal of Gerantology: Medical Sciences., 55A, M649 M657.
74. Piovella, F., Wang, C.-J., Lu, H., Lee, K., Lee, L.H., Lee, W.C., Turpie, A.G.G., Gallus, A.S., Planes, A., Passera, R. Rouillon, A.for.the.A.I.D.A. investigators. (2005) Deep-vein thrombosis rates after major orthopaedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography. Journal of Thrombosis and Haemostasis, 3, 2664 2670.
75. Poort, S.R., Rosendaal, F.R., Reitsma, P.H. Bertina, R.M. (1996) A common genetic variant in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood, 88, 3698 3703.
76. Prandoni, P., Lensing, A.W.A., Cogo, A., Cuppini, S., Villalta, S., Carta, M., Cattelan, M.A., Polistena, P., Bernadi, E. Prins, M.H. (1996) The long term clinical course of acute deep vein thrombosis. Annals of Internal Medicine, 125, 1 7.
77. Rahimi, Z., Vaisi-Raygani, A., Mozafari, H., Kharrazi, H., Rezaei, M. Nagel, R.L. (2008) Prevalence of Factor V Leiden (G1691A) and prothrombin (G20210A) among Kurdish population in Western Iran. Journal of Thrombosis and Thrombolysis, 25, 280 283.
78. Rees, D.C., Cox, M. Clegg, J.C. (1995) World distribution of Factor V Leiden. Lancet, 346, 1133 1134.
79. Rees, D.C., Chapman, N.H., Webster, M.T., Guerreiro, J.F., Rochette, J. Clegg, J.B. (1999) Born to clot: the European burden. British Journal of Haematology, 105, 564 566.
80. Ridker, P.M., Hennekens, C.H., Lindpainter, K., Stampfer, M.J., Eisenberg, P.R. Miletich, J.P. (1995) Mutation in the gene coding for coagulation Factor V and the risk of myocardial infarction, stroke and venous thrombosis in apparently healthy men. New England Journal of Medicine, 332, 912 917.
81. Ridker, P.M., Miletich, J.P., Hennekens, C.H. Buring, J.E. (1997) Ethnic distribution of Factor V Leiden in 4047 men and women. Journal of the American Medical Association, 277, 1305 1307.
82. Risch, N., Burchard, E., Ziv, E. Tang, H. (2002) Categorization of humans in biomedical research: genes, race and disease. Genome Biology, 3, 1 12.
83. Rosendaal, F.R., Koster, T., Vandenbroucke, J.P. Reitsma, P.H. (1995) High risk of thrombosis in patients homozygous for FV Leiden (activated protein C resistance). Blood, 85, 1504 1508.
84. Rosendaal, F.R., Doggen, C.J.M., Zivelin, A., Arruda, V.R., Aiach, M., Siscovick, D.S., Hillarp, A., Watske, H.H., Bernardi, F., Cumming, A.M., Preston, F.E. Reitsma, P.H. (1998) Geographic distribution of the 20210 G to A prothrombin variant. Thrombosis and Haemostasis, 79, 706 708.
85. Rosendaal, F.R., van Hylckama Vlieg, A., Tanis, B.C. Helmerhorst, F.M. (2003) Estrogens, progestogens and thrombosis. Journal of Thrombosis and Haemostasis, 1, 1371 1380.
86. Rotimi, C.N. (2004) Are medical and nonmedical uses of large-scale genomic markers conflating genetics and 'race'? Nature Genetics, 36, S43 S47.
87. Said, J.M., Brennecke, S.P., Moses, E.K., Walker, S.P., Borg, A.J., Williams, J.T. Higgings, J.R. (2006) Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population. Human Biology, 78, 403 412.
88. Sakata, T., Okamoto, A., Mannami, T., Tomoike, H. Miyata, T. (2004a) Protein C and antithrombin deficiency are important risk factors for deep vein thrombosis in Japanese. Journal of Thrombosis and Haemostasis, 2, 528 530.
89. Sakata, T., Okamoto, A., Mannami, T., Tomoike, H. Miyata, T. (2004b) Prevalence of protein S deficiency in the Japanese general population: the Suita study. Journal of Thrombosis and Haemostasis, 2, 1012 1013.
90. Sakon, M., Maehara, Y., Yoshikawa, H. Akaza, H. (2006) Incidence of venous thromboembolism following major abdominal surgery: a multi-centre prospective epidemiological study. Journal of Thrombosis and Haemostasis, 4, 581 586.
91. Sanker, P. Cho, M.K. (2002) Toward a new vocabulary of human genetic variation. Science, 298, 1337 1338.
92. Schelleman, H., Limdi, N.A. Kimmel, S.E. (2008) Ethnic differences in warfarin maintenance dose requirement and its relationship with genetics. Pharmacogenomics, 9, 1331 1346.
93. Schneider, D., Lillenfield, D.E. Im, W. (2006) The epidemiology of pulmonary embolism: racial contrasts in incidence and in-hospital case fatality rates. Journal of the National Medical Association, 98, 1967 1972.
94. Shen, M.-C., Lin, J.-S. Tsay, W. (1997) High prevalence of antithrombin III, protein C and protein S deficiency, but no Factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan. Thrombosis Research, 87, 377 385.
95. Shen, M.-C., Lin, J.-S. Tsay, W. (2000) Protein C and Protein S deficiencies are the most important risk factors associated with thrombosis in Chinese venous thrombophilic patients in Taiwan. Thrombosis Research, 99, 447 452.
96. Siddique, R.M., Siddique, M.I., Connors, A.F. Rimm, A.A. (1996) Thirty-day case-fatality rates for pulmonary embolism in the elderly. Archives of Internal Medicine, 156, 2343 2347.
97. Silverstein, M.D., Heit, J.A., Mohr, D.N., Petterson, T.M., O'Fallon, W.M. Melton, L.J. (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Archives of Internal Medicine, 158, 585 593.
98. Soo, P.Y., Patel, R.K., Best, S., Arya, R. Thein, S.L. (2005) Detection of prothrombin gene polymorphism at position 20209 (PT20209C/T): pilot study in a black population in the United Kingdom. Thrombosis and Haemostasis, 93, 179 180.
99. Stein, P.D., Huang, H., Afzal, A. Noor, H.A. (1999) Incidence of acute pulmonary embolism in a General Hospital: relation to age, race and sex. Chest, 116, 909 913.
100. Stein, P.D., Hull, R.D., Patel, K.C., Olson, R.E., Ghali, W.A., Alshab, A.K. Meyers, F.A. (2003) Venous thromboembolic disease: comparison of the diagnostic process in blacks and whites. Archives of Internal Medicine, 163, 1843 1848.
101. Stein, P.D., Kayali, F. Olson, R.E. (2004a) Estimated case-fatality rate of pulmonary embolism, 1979-1998. American Journal of Cardiology, 93, 1197 1199.
102. Stein, P.D., Kayali, F., Olson, R.E. Milford, C.E. (2004b) Pulmonary thromboembolism is Asians/Pacific Islanders in the United States: analysis of Data from the National Hospital Discharge Survey and the United States Census Bureau. American Journal of Medicine, 116, 435 442.
103. Stein, P.D., Kayali, F., Olson, R.E. Milford, C.E. (2004c) Pulmonary thromboembolism in American Indians and Alaskan Natives. Archives of Internal Medicine, 164, 1804 1806.
104. Stein, P.D., Beemath, A., Meyers, F.A., Skaf, E., Sanchez, J. Olson, R.E. (2006) Incidence of venous thromboembolism in hospitalised patients with cancer. American Journal of Medicine, 119, 60 68. (Pubitemid 43117468)
105. Suihesa, E., Nomara, T., Kawasaki, T. Kanakura, Y. (2001) Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis. Journal of Thrombosis and Thrombolysis, 12, 95 99.
106. Tait, H.R., Walker, I.D., Perry, D.J., Islam, I.A.M., Daly, M.E., McCall, F., Conkie, J.A. Carrell, R.W. (1994) Prevalence of antithrombin deficiency in the healthy population. British Journal of Haematology, 87, 106 112.
107. Takahashi, H., Wilkinson, G.R., Nutescu, E.A., Morita, T., Ritchie, M.D., Scordo, M.G., Pengo, V., Barban, M., Padrini, R., Ieiri, I., Otsubo, K., Kashima, T., Kimura, S., Kijima, S. Echizen, H. (2006) Different contributions of polymorphisms in the VKORC1 and CYP29C to intra- and inter- population differences in maintenance dose of warfarin in Caucasians, Japanese and African-Americans. Pharmacogenetics and genomics, 16, 101 110.
108. Tan, K.K., Koh, W.P. Chao, A.K.H. (2007) Risk factors and presentation of deep venous thrombosis among Asian patients: a hospital-based case-control study in Singapore. Annals of Vascular Surgery, 21, 490 495.
109. The International Warfarin Pharmacogenetics Consortium. (2009) Estimation of the warfarin dose with clinical and pharmacogenetic data. New England Journal of Medicine, 360, 753 764.
110. Thomas, W.A., Davies, J.N.P., O'Neal, R.M. Dimakulangan, A.A. (1960) Incidence of myocardial infarction correlated with venous and pulmonary thrombosis and embolism: a geographical study based on autopsies in Uganda, East Africa and St Louis, USA. American Journal of Cardiology, 5, 41 47.
111. Van Hylckama Vleig, A., Callas, P.W., Cushman, M., Bertina, R.M. Rosendaal, F.R. (2003) Inter-relation of coagulation factors and D-dimer levels in healthy individuals. Journal of Thrombosis and Haemostasis, 1, 516 522.
112. Warshawsky, I., Hren, C., Sercia, L., Shadrach, B., Deitcher, S.R., Newton, E. Kottke-Marchant, K. (2002) Detection of a novel point mutation of the prothrombin gene at position 20209. Diagnostic Molecular Pathology, 11, 152 156.
113. Wells, P.S., Anderson, D.R., Rodger, M., Forgie, M., Kearon, C., Dreyer, J., Kovacs, G., Mitchell, M., Lewandowski, B. Kovacs, M.J. (2003) Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. New England Journal of Medicine, 349, 1127 1135.
114. White, R.H., Zhou, H. Romano, P.S. (1998) Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Annals of Internal Medicine, 128, 737 740.
115. White, R.H., Zhou, H. Gage, B.F. (2004) Effect of age on the incidence of venous thromboembolism following major surgery. Journal of Thrombosis and Haemostasis, 2, 1327 1333.
116. White, R.H., Zhou, H., Murin, S. Harvey, D. (2005) Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California. Thrombosis and Haemostasis, 93, 298 305.
117. White, R.H., Dager, W.E., Zhou, H. Murin, S. (2006) Racial and gender differences in the incidence of recurrent venous thromboembolism. Thrombosis and Haemostasis, 96, 267 273.
118. Yoo, M.C., Kang, C.S., Kim, Y.H. Kim, S.K. (1997) A prospective randomised study on the use of nadroparin calcium in the prophylaxis of thromboembolism in Korean patients undergoing elective total hip replacement. International Orthopaedics, 21, 399 402.
119. Zivelin, A., Griffin, J.H., Xu, X., Pabinger, I., Samama, M., Conard, J., Brenner, B., Eldor, A. Seligsohn, U. (1997) A single genetic origin for a common Caucasian risk factor for venous thrombosis. Blood, 89, 397 402.