Abatacept does not induce direct gene expression changes in antigen-presenting cells

Journal of Clinical Immunology

Volumn 29, Issue 4, 2009, Pages 479-489

  Carman, Julie A ^a   Davis, Patricia M ^a   Yang, Wen Pin ^a   Zhu, Jun ^a   Chang, Han ^a   He, Aiqing ^a   Truong, Amy ^a   Suchard, Suzanne J ^a   Nadler, Steven G ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

abatacept; belatacept; costimulation; gene expression

Indexed keywords

ABATACEPT; BELATACEPT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; MESSENGER RNA; PHORBOL 12 ACETATE 13 MYRISTATE;

ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL POPULATION; DENDRITIC CELL; DRUG BINDING; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; PRIORITY JOURNAL; TREATMENT RESPONSE;

ANTIGEN PRESENTATION; ANTIGENS, CD80; ANTIGENS, CD86; B-LYMPHOCYTES; CELL LINE, TUMOR; CYTOKINES; DENDRITIC CELLS; GENE EXPRESSION; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; PHORBOL ESTERS;

EID: 67651241484     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-009-9282-z     Document Type: Article

References (31)

1. O Acuto F Michel 2003 CD28-mediated co-stimulation: a quantitative support for TCR signaling Nat Rev Immunol 3 939 951 (Pubitemid 37521536)
2. CB Thompson T Lindsten JA Ledbetter SL Kunkel HA Young SG Emerson 1989 CD28 activation pathway regulates the production of multiple T cell-derived lymphokines/cytokines Proc Natl Acad Sci USA 86 1333 1337 (Pubitemid 19061540)
3. PS Linsley EA Clark JA Ledbetter 1990 T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1 Proc Natl Acad Sci USA 87 5031 5035
4. DJ Lenschow TL Walunas JA Bluestone 1996 CD28/B7 system of T cell costimulation Annu Rev Immunol 14 233 258 (Pubitemid 26130184)
5. MR Prabhu Das SS Zamvil F Borriello HL Weiner AH Sharpe VK Kuchroo 1995 Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation Eur J Immunol 25 207 211
6. M Azuma D Ito H Yagita K Okumura JH Phillips LL Lanier 1993 B70 antigen is a second ligand for CTLA-4 and CD28 Nature 366 76 79
7. KS Hathcock G Laszlo C Pucillo P Linsley RJ Hodes 1994 Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function J Exp Med 180 631 640 (Pubitemid 24224140)
8. TK Lindsten P Lee ES Harris B Petryniak N Craighead PJ Reynolds 1993 Characterization of CTLA-4 structure and expression on human T cells J Immunol 151 3489 3499 (Pubitemid 23282661)
9. PS Linsley JL Greene W Brady J Bajorath JA Ledbetter R Peach 1994 Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors Immunity 1 793 801
10. TL Walunas DJ Lenschow CY Bakker PS Linsley GJ Freeman JM Green 1994 CTLA-4 can function as a negative regulator of T cell activation Immunity 1 405 413
11. PM Davis R Abraham L Xu SG Nadler SJ Suchard 2007 Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity J Rheum 34 2204 2210 (Pubitemid 350076880)
12. PM Davis SG Nadler DK Stetsko SJ Suchard 2008 Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction Clin Immunol 126 38 47 (Pubitemid 350266453)
13. PS Linsley W Brady M Urnes LS Grosmaire NK Damle JA Ledbetter 1991 CTLA-4 is a second receptor for the B cell activation antigen B7 J Exp Med 174 561 569
14. U Grohmann C Orabona F Fallarino C Vacca F Calcinaro A Falorni 2002 CTLA-4-Ig regulates tryptophan catabolism in vivo Nat Immunol 3 1097 1101 (Pubitemid 35363664)
15. DH Munn MD Sharma AL Mellor 2004 Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells J Immunol 172 4100 4110 (Pubitemid 38375222)
16. S Suvas V Singh S Sahdev H Vohra JN Agrewala 2002 Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma J Biol Chem 277 7766 7775 (Pubitemid 34968223)
17. CP Larsen TC Pearson AB Adams P Tso N Shirasugi E Strobert 2005 Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA-4-Ig with potent immunosuppressive properties Am J Transplant 5 443 53
18. RA Irizarry B Hobbs F Collin YD Beazer-Barclay KJ Antonellis U Scherf 2003 Exploration, normalization, and summaries of high density oligonucleotide array probe level data Biostatistics 4 249 264
19. DB Knoerzer RW Karr BD Schwartz LJ Mengle-Gaw 1995 Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig J Clin Invest 96 987 993
20. LMC Webb MJ Walmsley M Feldmann 1996 Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2 Eur J Immunol 26 2320 2328 (Pubitemid 26340930)
21. T Arima A Rehman WF Hickey MW Flye 1996 Inhibition by CTLA4Ig of experimental allergic encephalomyelitis J Immunol 156 4916 4924 (Pubitemid 26174480)
22. BK Finck PS Linsley D Wofsy 1994 Treatment of murine lupus with CTLA4Ig Science 265 1225 1227 (Pubitemid 24291979)
23. JM Kremer M Dougados P Emery P Durez J Sibilia W Shergy 2005 Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept Arthritis Rheum 52 2263 2271
24. MC Genovese J Becker M Schiff M Luggen Y Sherrer J Kremer 2005 Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition N Engl J Med 353 1114 1123 (Pubitemid 41317434)
25. F Vincenti C Larsen A Durrbach T Wekerle B Nashan G Blancho 2005 Costimulation blockade with belatacept in renal transplantation N Engl J Med 353 770 781 (Pubitemid 41215486)
26. A Boasso J Herbeuval AW Hardy C Winkler GM Shearer 2005 Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells Blood 105 1574 1581 (Pubitemid 40223677)
27. B Baban AM Hansen PR Chandler A Manlapat A Bingaman DJ Kahler 2005 A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation Int Immunol 17 909 919 (Pubitemid 41417958)
28. AM Boruchov G Heller M Veri E Bonvini JV Ravetch JW Young 2005 Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions J Clin Invest 115 2914 2923 (Pubitemid 41434419)
29. M Veri S Gorlatov H Li S Burke S Johnson J Stavenhagen 2007 Monoclonal antibodies capable of discriminating the human inhibitory Fcγ-receptor IIB (CD32B) from the activating Fcγ-receptor IIA (CD32A): biochemical, biological and functional characterization Immunology 121 392 404 (Pubitemid 46817361)
30. CT Rankin M Veri S Gorlatov N Tuaillon S Burke L Huang 2006 CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma Blood 108 2384 2391 (Pubitemid 44497523)
31. V Viglietta K Bourcier GJ Buckle B Healy 2008 CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase I clinical trial Neurology 71 917 924