Inhibition by CTLA4Ig of experimental allergic encephalomyelitis

Journal of Immunology

Volumn 156, Issue 12, 1996, Pages 4916-4924

  Arima, Takeshi ^a   Rehman, Atiq ^a   Hickey, William F ^b   Flye, M Wayne ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c BARNES JEWISH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; FEMALE; GUINEA PIG; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOCONJUGATES; IMMUNOSUPPRESSION; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; RATS; RATS, INBRED LEW; SIGNAL TRANSDUCTION; SPINAL CORD; T-LYMPHOCYTES; TIME FACTORS;

EID: 0029886610     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Jenkins, M., and R. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
2. Muller, D. L., M. K. Jenkins, L. Chiodetti, and R. H. Schwartz. 1990. An intracellular calcium increase and protein kinase C activation fail to initiate T cell proliferation in the absence of a costimulatory signal. J. Immunol. 144:3701.
3. Williams, I. R., and E. R. Unaue. 1991. Characterization of accessory cell costimulation of Th1 cytokine synthesis. J. Immunol. 147:3752.
4. Schwartz, R. H. 1990. A cell culture model for T-lymphocyte clonal anergy. Science 248:1349.
5. Linsley, P., and J. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
6. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
7. Freeman, G. J., A. S. Freeman, J. M. Segil, G. Lee, J. F. Whitman, and L. M. Nadler. 1989. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J. Immunol. 143:2714.
8. Freeman, G. J., J. G. Gribben, A. Boussiotis, J. W. Ng, V. A. Restivo, Jr., L. A. Lombard, G. S. Gray, and L. M. Nadler. 1993. Cloning of B7-2: a CTLA4 counter-receptor that costimulates human T cell proliferation. Science 262:909.
9. Freeman, G. J., F. Borriello, R. J. Hodes, H. Reiser, J. G. Gribben, J. W. Ng, J. Kim, J. M. Goldberg, K. Hathcock, and G. Laszlo. 1993. Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin-2 production. J. Exp. Med. 178:2185.
10. Caux, C., B. Vanbervliet, C. Massacrier, M. Azuma, K. Okumura, L. L. Lanier, and J. Banchereau. 1994. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180: 1841.
11. Azuma, M., D. Ito, H. Yagita, K. Okumura, J. H. Phillips, L. L. Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA4 and CD28. Nature 366:76.
12. Linsley, P. S., E. A. Clark, and J. A. Ledbetter. 1990. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad. Sci. USA 87:5031.
13. Linsley, P. S., W. Brady, L. S. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173:721.
14. Gimmi, C. D., G. J. Freeman, J. G. Gribben, K. Sugita, A. S. Freedman, C. Morimoto, and L. M. Nadler. 1991. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc. Natl. Acad. Sci. USA 88:6575.
15. Jenkins, M. K., P. S. Taylor, S. D. Norton, and K. B. Urdahl. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 147:2461.
16. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
17. Gimmi, C. D., G. J. Freeman, J. G. Gribben, G. Gray, and L. M. Nadler. 1993. Human T cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc. Natl. Acad. Sci. USA 90:6586.
18. Tan, P., C. Anasetti, J. A. Hansen, J. Melrose, M. Brunvard, K. Bradshaw, J. A. Ledbetter, and P. S. Linsley. 1993. Induction of alloantigen-specific unresponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177:165.
19. Boussiotis, V. A., G. J. Freeman, G. Gray, J. G. Gribben, and L. M. Nadler. 1993. B7 but not intracellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J. Exp. Med. 178:1753.
20. Brunet J. F., F. Denizot, M. F. Luciani, M. Roux-Dosseto, M. Susan, M. G. Mattei, and P. Golstein. 1987. A new member of the immunoglobulin superfamily - CTLA4. Nature 328:267.
21. Linsley, P. S., J. L. Greene, P. Tan, J. Bradshaw, J. A. Ledbetter, C. Anasetti, and N. K. Damle. 1992. Co-expression and functional cooperation of CTLA4 and CD28 on activated T cells. J. Exp. Med. 176:1595.
22. Stein, P., J. Fraser, and A. Weiss. 1994. The cytoplasmic domain of CD28 is both necessary and sufficient for co-stimulation of IL-2 secretion and association with phosphatidylinositol 3′-kinase. Mol. Cell. Biol. 14:3392.
23. Linsley, P. S., W. Brady, M. Urnes, L. S. Grosmaire, N. K. Damle, and J. A. Ledbetter. 1991. CTLA4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174:561.
24. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol Today 15:321.
25. Linsley, P. S., P. M. Wallace, J. Johnson, M. G. Gibson, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA4 T cell activation molecule. Science 257:792.
26. Lenschow, D. J., Y. Zeng, J. R. Thistlethwaite, A. Montag, W. Brady, M. G. Gibson, P. S. Linsley, and J. A. Bluestone. 1992. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257:789.
27. Turka, L. A., P. S. Linsley, H. Lin, W. Brady, J. M. Leiden, R. Q. Wei, M. L. Gibson, X. G. Zheng, S. Myrdal, D. Gordon, T. Bailey, S. F. Bolling, and C. B. Thompson. 1992. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc. Natl. Acad. Sci. USA 89:11102.
28. Lin, H., S. F. Bolling, P. S. Linsley, R. Q. Wei, D. Gordon, C. B. Thompson, and L. A. Turka. 1993. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J. Exp. Med. 178:1801.
29. Pearson, T. C., D. Z. Alexander, K. J. Winn, P. S. Linsley, R. P. Lowry, and C. P. Larsen. 1994. Transplantation tolerance induced by CTLA4Ig. Transplantation 57:1701.
30. Wallace, P. M., J. S. Johnson, J. F. MacMaster, K. A. Kennedy, P. Gladstone, and P. S. Linsley. 1994. CTLA4Ig treatment ameliorates the lethality of murine graft-versus-host disease across major histocompatibility complex barriers. Transplantation 58:602.
31. Finck, B. K., P. S. Linsley, and D. Wofsy. 1994. Treatment of murine lupus with CTLA4Ig. Science 265:1225.
32. Ando, D. G., J. Clayton, D. Kono, J. L. Urban, and E. E. Sercarz. 1989. Encephalitogenic T cells in the B10. PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124:132.
33. Mustafa, M., C. Vingsbo, T. Olsson, A. Ljungdahl, B. Hojeberg, and R. Holmdahl. 1993. The major histocompatibility complex influences myelin basic protein 63-88 induced T cell cytokine profile and experimental autoimmune encephalomyelitis. Eur. J. Immunol. 23:3089.
34. Martin, R., H. F. McFarland, and D. E. McFarin. 1992. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:153.
35. Perrin, P. J., D. Scott, L. Quigley, P. S. Albert, O. Feder, G. S. Gray, R. Abe, C. H. June, and M. K. Racke. 1995. Role of B7:CD28/CTLA4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 154: 1481.
36. Norton, W. T., and S. E. Poduslo. 1973. Myelination in rat brain: method of myelin isolation. J. Neurochem. 21:749.
37. Levine, S., and E. J. Wenk. 1964. Allergic encephalomyelitis: a hyperacute form. Science 146:1681.
38. Wekerle, H., K. Kojima, J. Lannes-Vieira, H. Lassmann, and C. Linington. 1994. Animal models. Ann. Neurol. 36:S47.
39. Trotter, J. L., and C. L. Wegeschiede. 1985. Isolation and purification of myelinproteolipid protein using high speed gel filtration in sodium dodecyl sulfate. Neurochem. Res. 10:865.
40. White, S. R., G. K. Samathanam, R. M. Bowker, and M. W. Wessendorf. 1990. Damage to bulbospinal serotonin-, tyrosine hydroxylase-, and TRH-containing axons occurs early in the development of experimental allergic encephalomyelitis in rats. J. Neurosci. Res. 27:89.
41. Schorlemmer, H. U., and F. R. Seiler. 1991. Therapeutic effects of 15-deoxyspergualin in acute and chronic relapsing experimental allergic encephalomyelitis (EAE) as models for multiple sclerosis (MS). Drugs Exp. Clin. Res. 17:461.
42. Cross, A. H., T. J. Girard, K. S. Giacoletto, R. J. Evans, R. M. Keeling, R. F. Lin, J. L. Trotter, and R. W. Karr. 1995. Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA4-Fc supports a key role for CD28 costimulation. J. Clin. Invest. 95:2783.
43. Linthicum, D. S., and J. A. Frelinger. 1982. Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes. J. Exp. Med. 156:31.
44. Teuscher, C., Z. Z. Zhou, Y. Zheng, and W. F. Hickey. 1989. Actively induced experimental allergic orchitis in Lewis-resistant (Le-R) rats: reversibility of disease resistance by immunization with Bordetella pertussis. Cell. Immunol. 119: 233.
45. Kuchroo, V. K., C. A. Martin, J. M. Greer, S. T. Ju, R. A. Sobel, and M. E. Dorf. 1993. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol. 151:4371.
46. Tuomanen, E. I., S. M. Prasad, J. S. George, A. I. Hoepelman, P. Ibsen, I. Heron, and R. M. Starzyk. 1993. Reversible opening of the blood-brain barrier by antibacterial antibodies. Proc. Natl. Acad. Sci. USA 90:7824.
47. Brostoff, S. W., and D. W. Mason. 1984. Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells. J. Immunol. 133:1938.
48. Steinman, L., J. T. Rosenbaum, S. Sriram, and H. O. McDevitt. 1981. In vivo effects of antibodies to immune response gene products: prevention of experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 78:7111.
49. Acha-Orbea, H., D. J. Mitchell, L. Timmermann, D. C. Wraith, G. S. Tausch, M. K. Walder, S. S. Zamvil, H. O. McDevitt, and L. Steinman. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263.
50. Ben-Nun, A., H. Wekerle, and I. R. Cohen. 1981. Vaccination against autoimmune encephalomyelitis with T-lymphocyte lines reactive against myelin basic protein. Nature 292:60.
51. Offner, H., G. A. Hashim, and A. A. Vandenbark. 1991. T cell receptor peptide therapy triggers autoreguration of experimental encephalomyelitis. Science 251: 430.
52. + T lymphocytes. J. Immunol. 142:748.
53. Kennedy, M. K., M. C. Dal Canto, J. L. Trotter, and S. D. Miller. 1988. Specific immune regulation of chronic-relapsing experimental allergic encephalomyelitis in mice. J. Immunol. 141:2986.
54. Sharma, S. D., B. Nag, X. M. Su, D. Green, E. Spack, B. R. Clark, and S. Sriram. 1991. Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes. Proc. Natl. Acad. Sci. USA 88:11465.
55. Goss, J. A., Y. Nakafusa, C. R. Roland, W. F. Hickey, and M. W. Flye. 1994. Immunological tolerance to a defined myelin basic protein antigen administered intrathymically. J. Immunol. 153:3890.
56. Wallace, P. M., J. N. Rodgers, G. M. Leytze, J. S. Johnson, and P. S. Linsley. 1995. Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment. J. Immunol. 154:5885.
57. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
58. O'Neill, J. K., D. Baker, A. N. Davison, S. J. Allen, C. Butter, H. Waldmann, and J. L. Turk. 1993. Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies. J. Neuroimmunol. 45:1.
59. Williams, K., E. Ulvestad, and J. P. Antel. 1994. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur. J. Immunol. 24:3031.
60. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
61. Beverly, B., S. M. Kang, M. J. Lenardo, and R. H. Schwartz. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. 1992. Int. Immunol. 4:661.
62. Lindsey, J. W., S. Hodgkinson, R. Mehta, D. Mitchell, D. Enzmann, and L. Steinman. 1994. Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis. Ann. Neurol. 36:183.