Investigation of the local expression of the relaxin system in canine mammary tumours

Reproduction in Domestic Animals

Volumn 44, Issue SUPPL. 2, 2009, Pages 224-229

  Lamp, O ^b   Honscha, K U ^b   Jakob, J ^b   Lamp, J ^b   Schweizer, S ^b   Reischauer, A ^b   Gottschalk, J ^b   Hahn, A ^b   Ebert, M ^b   Rothemund, S ^c   Blaschzik, S ^b   Einspanier, A ^a,b  

^a Faculty of Veterinary Medicine ^*  (Germany)

^b Faculty of Veterinary Medicine   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; RECEPTOR; RELAXIN; TUMOR MARKER;

ANIMAL; CONFERENCE PAPER; DOG; DOG DISEASE; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; MAMMARY NEOPLASMS, ANIMAL; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RELAXIN; TUMOR MARKERS, BIOLOGICAL;

CANIDAE; CANIS FAMILIARIS;

EID: 67651233838     PISSN: 09366768     EISSN: 14390531     Source Type: Journal    
DOI: 10.1111/j.1439-0531.2009.01385.x     Document Type: Conference Paper

References (33)

1. Binder C, Hagemann T, Husen B, Schulz M, Einspanier A, 2002: Relaxin enhances in vitro invasiveness of breast cancer cell lines by up-regulation of matrix metalloproteases. Mol Hum Reprod 8, 789 796.
2. Binder C, Simon A, Binder L, Hagemann T, Schulz M, Emons G, Trumper L, Einspanier A, 2004: Elevated concentrations of serum relaxin are associated with metastatic disease in breast cancer patients. Breast Cancer Res Treat 87, 157 166.
3. Dragoo JL, Lee RS, Benhaim P, Finerman GA, Hame SL, 2003: Relaxin receptors in the human female anterior cruciate ligament. Am J Sports Med 31, 577 584.
4. Dschietzig T, Richter C, Bartsch C, Laule M, Armbruster FP, Baumann G, Stangl K, 2001: The pregnancy hormone relaxin is a player in human heart failure. FASEB J 15, 2187 2195.
5. Einspanier A, Hodges JK, 1994: LH- and chorionic gonadotrophin-stimulated progesterone release in vitro by intact luteal tissue of the marmoset monkey (Callithrix jacchus). J Endocrinol 141, 403 409.
6. Einspanier A, Bunck C, Salpigtidou P, Marten A, Fuhrmann K, Hoppen HO, Gunzel-Apel AR, 2002: Relaxin: ein wichtiger Graviditätsindikator bei der Hündin (relaxin: an important indicator of canine pregnancy). Dtsch Tierarztl Wochenschr 109, 8 12.
7. Goldsmith LT, Lust G, Steinetz BG, 1994: Transmission of relaxin from lactating bitches to their offspring via suckling. Biol Reprod 50, 258 265.
8. Gottschalk J, 1999: Validierte Methode zur Bestimmung von Progesteron und 17beta-Oestradiol. Labormitteilungen an das Institut für Tierarzneimittel Berlin GmbH, Berlin.
9. Henneman S, Bildt MM, Degroot J, Kuijpers-Jagtman AM, Von den Hoff JW, 2008: Relaxin stimulates MMP-2 and alpha-smooth muscle actin expression by human periodontal ligament cells. Arch Oral Biol 53, 161 167.
10. Hirayama K, Yokota H, Onai R, Kobayashi T, Kumata T, Kihara K, Okamoto M, Sako T, Nakade T, Izumisawa Y, Taniyama H, 2002: Detection of matrix metalloproteinases in canine mammary tumours: analysis by immunohistochemistry and zymography. J Comp Pathol 127, 249 256.
11. Hsu SY, Nakabayashi K, Nishi S, Kumagi J, Kudo M, Sherwood OD, Hsueh AJ, 2002: Activation of orphan receptors by the hormone relaxin. Science 295, 671 674.
12. Kaskous S, Gottschalk J, Hippel T, Grun E, 2003: The behavior of growth-influencing and steroid hormones in the blood plasma during pregnancy of Awassi sheep in Syria. Berl Munch Tierarztl Wochenschr 116, 108 116. (Pubitemid 36360366)
13. Kawai K, Uetsuka K, Doi K, Nakayama H, 2006: The activity of matrix metalloproteinases (MMPS) and tissue inhibitors of metalloproteinases (TIMPs) in mammary tumors of dogs and rats. J Vet Med Sci 68, 105 111.
14. Klonisch T, Hombach-Klonisch S, Froehlich C, Kauffold J, Steger K, Steinetz BG, Fischer B, 1999: Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. Biol Reprod 60, 551 557. (Pubitemid 29102382)
15. Marinelli L, Gabai G, Wolfswinkel J, Mol JA, 2004: Mammary steroid metabolizing enzymes in relation to hyperplasia and tumorigenesis in the dog. J Steroid Biochem Mol Biol 92, 167 173.
16. Mazoujian G, Bryant-Greenwood GD, 1990: Relaxin in breast tissue. Lancet 335, 298 299.
17. Misdorp W, Hellmen E, Else RW, Lipscomb TP, 1999: Histological Classification of Mammary Tumors of the Dog and the Cat, 2nd series. VII. Armed Forces Institute of Pathology, Washington DC.
18. Owen LN, 1980: TNM Classification of Tumours in Domestic Animals, 1st edn. World Health Organization, Geneva, pp. 21 25.
19. Palejwala S, Stein DE, Weiss G, Monia BP, Tortoriello D, Goldsmith LT, 2001: Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway. Endocrinology 142, 3405 3413.
20. Papparella S, Restucci B, Maiolino P, De Vico G, 1997: Immunohistochemical distribution of type IV collagenase in normal, dysplastic and neoplastic canine mammary gland. J Comp Pathol 117, 277 282.
21. Papparella S, Restucci B, Paciello O, Maiolino P, 2002: Expression of matrix metalloprotease-2 (MMP-2) and the activator membrane type 1 (MT1-MMP) in canine mammary carcinomas. J Comp Pathol 126, 271 276.
22. Peaker M, Taylor E, Tashima L, Redman TL, Greenwood FC, Bryant-Greenwood GD, 1989: Relaxin detected by immunocytochemistry and northern analysis in the mammary gland of the guinea pig. Endocrinology 125, 693 698.
23. Queiroga FL, Perez-Alenza MD, Silvan G, Pena L, Lopes CS, Illera JC, 2008: Crosstalk between GH/IGF-I axis and steroid hormones (progesterone, 17beta-estradiol) in canine mammary tumours. J Steroid Biochem Mol Biol 110, 76 82.
24. Rutteman GR, 2005: Mammatumoren des Hundes. In: Kessler M (ed Kleintieronkologie. Enke, Stuttgart, pp. 237 248.
25. Schweizer S, Lamp O, Reischauer A, Lamp J, Blaschzik S, Grevel V, Einspanier A, 2007: Investigation of the plasma relaxin levels in bitches with mammary gland tumours as a potential prognostic marker. Reprod Domest Anim 42 (Suppl 1 29.
26. Silvertown JD, Geddes BJ, Summerlee AJ, 2003: Adenovirus-mediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells. Endocrinology 144, 3683 3691.
27. Simon D, Schönrock D, Ueberschär S, Siebert J, Nolte I, 2001: Mammatumoren des Hundes: Diagnostik und Therapie. Tierärztl Prax 29(K), 47 50.
28. Steinetz BG, Goldsmith LT, Lust G, 1987: Plasma relaxin levels in pregnant and lactating dogs. Biol Reprod 37, 719 725.
29. Steinetz BG, Goldsmith LT, Harvey HJ, Lust G, 1989: Serum relaxin and progesterone concentrations in pregnant, pseudopregnant, and ovariectomized, progestin-treated pregnant bitches: detection of relaxin as a marker of pregnancy. Am J Vet Res 50, 68 71.
30. Steinetz BG, Williams AJ, Lust G, Schwabe C, Bullesbach EE, Goldsmith LT, 2008: Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity. Am J Vet Res 69, 59 67.
31. Tashima LS, Mazoujian G, Bryant-Greenwood GD, 1994: Human relaxins in normal, benign and neoplastic breast tissue. J Mol Endocrinol 12, 351 364.
32. Tsutsui T, Stewart DR, 1991: Determination of the source of relaxin immunoreactivity during pregnancy in the dog. J Vet Med Sci 53, 1025 1029.
33. Yokota H, Kumata T, Taketaba S, Kobayashi T, Moue H, Taniyama H, Hirayama K, Kagawa Y, Itoh N, Fujita O, Nakade T, Yuasa A, 2001: High expression of 92 kDa type IV collagenase (matrix metalloproteinase-9) in canine mammary adenocarcinoma. Biochim Biophys Acta 1568, 7 12.