Segmental ischemia of the liver - Microdialysis in a novel porcine model

European Surgical Research

Volumn 43, Issue 3, 2009, Pages 276-285

  Winbladh, A ^a,c   Sandstrom P ^a,c   Olsson, H ^b   Svanvik, J ^a   Gullstrand, P ^a,c  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b Department of Pathology

^c Health University   (Sweden)

Author keywords

Ischemia reperfusion injury; Laser Doppler flowmetry; Liver, pig

Indexed keywords

ASPARTATE AMINOTRANSFERASE; GLUCOSE; GLYCEROL; LACTIC ACID; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; HISTOPATHOLOGY; IN VIVO STUDY; LASER DOPPLER FLOWMETRY; LIVER CIRCULATION; LIVER ISCHEMIA; MALE; MICRODIALYSIS; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; REPERFUSION INJURY; SWINE;

ANIMALS; DISEASE MODELS, ANIMAL; LASER-DOPPLER FLOWMETRY; LIVER; LIVER DISEASES; MALE; MICRODIALYSIS; REPERFUSION INJURY; SWINE;

EID: 67651230062     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000230675     Document Type: Article

References (31)

1. Jaeschke H: Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003; 284:G15-G26. (Pubitemid 36076246)
2. Fondevila C, Busuttil RW, Kupiec-Weglinski JW: Hepatic ischemia/reperfusion injury - a fresh look. Exp Mol Pathol 2003; 74: 86-93.
3. Malhi H, Gores GJ, Lemasters JJ: Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 2006; 43:S31-S44.
4. Zhang W, Wang M, Xie HY, Zhou L, Meng XQ, Shi J, Zheng S: Role of reactive oxygen species in mediating hepatic ischemia-reperfusion injury and its therapeutic applications in liver transplantation. Transplant Proc 2007; 39: 1332-1337.
5. Farges O, Malassagne B, Flejou JF, Balzan S, Sauvanet A, Belghiti J: Risk of major liver resection in patients with underlying chronic liver disease: a reappraisal. Ann Surg 1999; 229: 210-215.
6. Shirabe K, Shimada M, Gion T, Hasegawa H, Takenaka K, Utsunomiya T, Sugimachi K: Postoperative liver failure after major hepatic resection for hepatocellular carcinoma in the modern era with special reference to remnant liver volume. J Am Coll Surg 1999; 188: 304-309.
7. Kanoria S, Glantzounis G, Jalan R, Davies NA, Seifalian AM, Williams R, Davidson BR: A model to study total hepatic ischemiareperfusion injury. Transplant Proc 2004; 36: 2586-2589.
8. Asakawa H, Jeppsson B, Mack P, Hultberg B, Hagerstrand I, Bengmark S: Acute ischemic liver failure in the rat: a reproducible model not requiring portal decompression. Eur Surg Res 1989; 21: 42-48.
9. Spiegel HU, Bahde R: Experimental models of temporary normothermic liver ischemia. J Invest Surg 2006; 19: 113-123.
10. Sankary HN, Yin DP, Chong AS, Ma LL, Blinder L, Shen JK, Foster P, Liu LP, Li C, Williams JW: The portosystemic shunt protects liver against ischemic reperfusion injury. Transplantation 1999; 68: 958-963.
11. Nakamura N, Hamada N, Murata R, Kobayashi A, Ishizaki N, Taira A, Sakata R: Contribution of serotonin to liver injury following canine small-intestinal ischemia and reperfusion. J Surg Res 2001; 99: 17-24.
12. Hasselgren PO, Jennische E, Fornander J, Hellman A: No beneficial effect of ATPMgCl 2 on impaired transmembrane potential and protein synthesis in liver ischemia. Acta Chir Scand 1982; 148: 601-607.
13. Hayashi H, Chaudry IH, Clemens MG, Baue AE: Hepatic ischemia models for determining the effects of ATP-MgCl 2 treatment. J Surg Res 1986; 40: 167-175.
14. Yamauchi H, Baca I, Mittmann U, Geisen HP, Salzer M: Postischemic liver damage in rats: effect of some therapeutic interventions on survival rate. Tohoku J Exp Med 1982; 138: 63-70.
15. Ungerstedt J, Nowak G, Ericzon BG, Ungerstedt U: Intraperitoneal microdialysis (IPM): a new technique for monitoring intestinal ischemia studied in a porcine model. Shock 2003; 20: 91-96.
16. Nowak G, Ungerstedt J, Wernerman J, Ungerstedt U, Ericzon BG: Metabolic changes in the liver graft monitored continuously with microdialysis during liver transplantation in a pig model. Liver Transpl 2002; 8: 424-432.
17. Mongan PD, Capacchione J, West S, Karaian J, Dubois D, Keneally R, Sharma P: Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine. Am J Physiol Heart Circ Physiol 2002; 283:H1634-H1644.
18. Nowak G, Ungerstedt J, Wernerson A, Ungerstedt U, Ericzon BG: Hepatic cell membrane damage during cold preservation sensitizes liver grafts to rewarming injury. J Hepatobiliary Pancreat Surg 2003; 10: 200-205.
19. Rasmussen I, Hillered L, Ungerstedt U, Haglund U: Detection of liver ischemia using microdialysis during experimental peritonitis in pigs. Shock 1994; 1: 60-66.
20. Nowak G, Ungerstedt J, Wernerman J, Ungerstedt U, Ericzon BG: Clinical experience in continuous graft monitoring with microdialysis early after liver transplantation. Br J Surg 2002; 89: 1169-1175.
21. Kannerup AS, Funch-Jensen P, Gronbaek H, Jorgensen RL, Mortensen FV: Metabolic changes in the pig liver during warm ischemia and reperfusion measured by microdialysis. J Gastrointest Surg 2008; 12: 319-326.
22. Waelgaard L, Thorgersen EB, Line PD, Foss A, Mollnes TE, Tonnessen TI: Microdialysis monitoring of liver grafts by metabolic parameters, cytokine production, and complement activation. Transplantation 2008; 86: 1096-1103.
23. Court FG, Wemyss-Holden SA, Morrison CP, Teague BD, Laws PE, Kew J, Dennison AR, Maddern GJ: Segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy. Br J Surg 2003; 90: 440-444.
24. Koti RS, Yang W, Dashwood MR, Davidson BR, Seifalian AM: Effect of ischemic preconditioning on hepatic microcirculation and function in a rat model of ischemia reperfusion injury. Liver Transpl 2002; 8: 1182-1191.
25. Seifalian AM, Horgan LF, Davidson BR: Intraoperative assessment of liver perfusion by laser Doppler imaging in an animal model. Transplant Proc 1995; 27: 2866-2868.
26. Seifalian AM, Stansby GP, Hobbs KE, Hawkes DJ, Colchester AC: Measurement of liver blood flow: a review. HPB Surg 1991; 4: 171-186.
27. Mock T, Morrison D, Yatscoff R: Evaluation of the I-Stat system: a portable chemistry analyzer for the measurement of sodium, potassium, chloride, urea, glucose, and hematocrit. Clin Biochem 1995; 28: 187-192.
28. Sediame S, Zerah-Lancner F, d'Ortho MP, Adnot S, Harf A: Accuracy of the I-Stat bedside blood gas analyser. Eur Respir J 1999; 14: 214-217.
29. Rappaport AM, Borowy ZJ, Lougheed WM, Lotto WN: Subdivision of hexagonal liver lobules into a structural and functional unit: role in hepatic physiology and pathology. Anat Rec 1954; 119: 11-33.
30. Jaeschke H, Farhood A, Smith CW: Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990; 4: 3355-3359.
31. Mehrabi A, Golling M, Busch C, Hashemi B, Ahmadi R, Volkl A, Gebhard MM, Klar E, Kraus T: Experimental monitoring of hepatic glucose, lactate, and glutamate metabolism by microdialysis during surgical preparation of the liver hilus. J Surg Res 2002; 105: 128-135.