Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening

Journal of Biomedical Science

Volumn 16, Issue 1, 2009, Pages

  Jämsä, Anne ^a,b   Agerman, Karin ^a   Radesäter, Ann Cathrin ^a   Ottervald, Jan ^a   Malmström, Jonas ^a   Hiller, Gösta ^a   Liu, Gang ^a   Vasänge, Mervi ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 (6 CHLOROBENZOTHIAZOL 2 YL)THIOPHENE 2 SULFONAMIDE; 7 ETHYL 4 [(4 FLUOROPHENYL)AMINO] 3,5,7 TRIAZABICYCLO[4.4.0.]DECA 1,3,5,9 TETRAEN 8 ONE; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; MYOSIN HEAVY CHAIN; PROTEIN P25; ROSCOVITINE; UNCLASSIFIED DRUG; MYOSIN IIB; NONMUSCLE MYOSIN TYPE IIB HEAVY CHAIN; PROTEIN KINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; WESTERN BLOTTING; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION;

CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; DRUG EVALUATION, PRECLINICAL; HUMANS; MYOSIN HEAVY CHAINS; NONMUSCLE MYOSIN TYPE IIB; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 67651229501     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-16-55     Document Type: Article

References (33)

1. A family of human CDC2-related protein kinases. M Meyerson GH Enders CL Wu LK Su C Gorka C Nelson E Harlow LH Tsai, EMBO J 1992 11 2909 2917 1639063
2. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. LH Tsai I Delalle VS Caviness Jr T Chae E Harlow, Nature 1994 371 419 423 10.1038/371419a0 8090221
3. An isoform of the neuronal cyclin-dependent kinase 5 (cdk5) activator. D Tang J Yeung KY Lee M Matsushita H Matsui K Tomizawa O Hatase JH Wang, J Biol Chem 1995 270 26897 26903 10.1074/jbc.270.45.26897 7592934
4. Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. P Sharma M Sharma ND Amin RW Albers HC Pant, Proc Natl Acad Sci 1999 96 11156 11160 10500146 10.1073/pnas.96.20.11156
5. Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system. M Zheng CL Leung RK Liem, J Neurobiol 1998 35 141 159 10.1002/(SICI)1097- 4695(199805)35:2<141::AID-NEU2>3.0.CO;2-4 9581970
6. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. GN Patrick L Zukerberg M Nikolic S de la Monte P Dikkes LH Tsai, Nature 1999 402 615 622 10.1038/45159 10604467
7. A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. HC Tseng Y Zhou Y Shen LH Tsai, FEBS Lett 2002 523 58 62 10.1016/S0014-5793(02)02934-4 12123804
8. Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. KY Lee AW Clark JL Rosales K Chapman T Fung RN Johnston, Neurosci Res 1999 34 21 29 10.1016/S0168-0102(99)00026-7 10413323
9. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. PD Smith SJ Crocker V Jackson-Levis KL Jordan-Sciutto S Hayley MP Mount MJ O'Hare S Callaghan RS Slack S Przedborski H Anisman DS Park, Proc Natl Acad Sci 2003 100 13650 13655 14595022 10.1073/pnas.2232515100
10. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. MD Nguyen RC Lariviére J-P Julien, Neuron 2001 30 135 147 10.1016/S0896-6273(01)00268-9 11343650
11. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. J Wang SH Liu YP Fu JH Wang YM Lu, Nat Neurosci 2003 6 1039 1047 10.1038/nn1119 14502288
12. A hippocampal Cdk5 pathway regulates extinction of contextual fear. F Sananbenesi A Fischer X Wang C Schrick R Neve J Radulovic LH Tsai, Nat Neurosci 2007 10 1012 1019 17632506 10.1038/nn1943
13. Cyclin-dependent kinase 5 is required for associative learning. A Fischer F Sananbenesi C Schrick J Spiess J Radulovic, J Neurosci 2002 22 3700 3707 11978846
14. Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice. T Ohshima H Ogura K Tomizawa K Hayashi H Suzuki T Saito H Kamei A Nishi JA Bibb S Hisanaga H Matsui K Mikoshiba, J Neurochem 2005 94 917 925 10.1111/j.1471-4159.2005.03233.x 15992381
15. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. A Fischer F Sananbenesi PT Pang B Lu LH Tsai, Neuron 2005 48 825 838 10.1016/j.neuron.2005.10.033 16337919
16. The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation. A Jämsä K Hasslund RF Cowburn A Bäckström M Vasänge, Biochem Biophys Res Commun 2004 319 993 1000 10.1016/j.bbrc.2004.05.075 15184080
17. Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells. A Jämsä A Bäckström E Gustafsson N Dehvari G Hiller RF Cowburn M Vasänge, Biochem Biophys Res Commun 2006 345 324 331 10.1016/j.bbrc.2006.04.032 16678793
18. Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. M Barvian DH Boschelli J Cossrow E Dobrusin A Fattaey A Fritsch D Fry P Harvey P Keller M Garrett F La W Leopold D McNamara M Quin S Trumpp-Kallmeyer P Toogood Z Wu E Zhang, J Med Chem 2000 43 4606 4616 10.1021/jm000271k 11101352
19. WO 01/55148. RJ Booth A Chatterjee TC Malone
20. WO 2006/004507. J Malmström J Viklund
21. Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism. P Grant P Sharma HC Pant, Eur J Biochem 2001 268 1534 1546 10.1046/j.1432-1327.2001.02025.x 11248670
22. Abnormal Alzheimer-like phosphorylation of Tau-protein by cyclin-dependent kinases cdk2 and Cdk5. K Baumann EM Mandelkow J Biernat H Piwnica-Worms E Mandelkow, FEBS Lett 1993 336 417 424 10.1016/0014-5793(93) 80849-P 8282104
23. Evidence for the participation of the neuron-specific Cdk5 activator p35 during laminin-enhanced axonal growth. G Paglini G Pigino P Kunda G Morfini R Maccioni S Quiroga A Furreira A Caceres, J Neurosci 1998 18 9858 9869 9822744
24. Synaptic roles of Cdk5: Implications in higher cognitive functions and neurodegenerative diseases. ZH Cheung AKY Fu NY Ip, Neuron 2006 50 13 18 10.1016/j.neuron.2006.02.024 16600851
25. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. T Ohshima JM Ward CG Huh G Longenecker Veeranna HC Pant RO Brady LJ Martin AB Kulkarni, Proc Natl Acad Sci 1996 93 11173 11178 8855328 10.1073/pnas.93.20.11173
26. Callosal axon guidance defects in p35(-/-) mice. YT Kwon L-H Tsai JE Crandall, J Comp Neurol 1999 415 218 229 10.1002/(SICI)1096-9861(19991213)415: 2<218::AID-CNE6>3.0.CO;2-F 10545161
27. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and ERK1. Z Songyang KP Lu YT Kwon LH Tsai O Filhol C Cochet DA Brickey TR Soderling C Bartleson DJ Graves AJ DeMaggio MF Hoekstra J Blenis T Hunter LC Cantley, Mol Cell Biol 1996 16 6486 6493 8887677
28. Myosins: a diverse superfamily. JR Sellers, Biochim Biophys Acta 2000 1496 3 22 10.1016/S0167-4889(00)00005-7 10722873
29. Molecular mechanisms of nonmuscle myosin-II regulation. AR Bresnick, Curr Opin Cell Biol 1999 11 26 33 10.1016/S0955-0674(99)80004-0 10047526
30. Myosin reorganization in activated RBL cells correlates temporally with stimulated secretion. A Spudich, Cell Motil Cytoskel 1994 29 345 353 10.1002/cm.970290407
31. Two nonmuscle myosin II heavy chain isoforms expressed in rabbit brains: filament forming properties, the effects of phosphorylation by Protein kinase C and Casein kinase II, and location of the phosphorylation sites. M Murakami VPS Chauhan M Elzinga, Biochemistry 1998 37 1989 2003 10.1021/bi971959a 9485326
32. 2+, calmodulin-dependent protein kinases. E Tanaka K Fukunaga H Yamamoto T Iwasa E Miyamoto, J Neurochem 1986 47 254 262 10.1111/j.1471-4159.1986.tb00789.x 2940339
33. The CDK5 activator, p39, binds specifically to myosin essential light chain. DR Ledee BK Tripathi PS Zelenka, Biochem Biophys Res Commun 2007 354 1034 1039 17276406 10.1016/j.bbrc.2007.01.112