Ventilatory drive is enhanced in male and female rats following chronic intermittent hypoxia

Advances in Experimental Medicine and Biology

Volumn 648, Issue , 2009, Pages 337-344

  Edge, D ^a   Skelly, J R ^a   Bradford, A ^a   O'Halloran, K D ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Chronic intermittent hypoxia; Hypercapnic ventilatory response; Hypoxic ventilatory response; Plethysmography; Respiratory plasticity; Sleep apnoea

Indexed keywords

NITROGEN;

AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; BODY MASS; BODY PLETHYSMOGRAPHY; BREATHING MUSCLE; CHRONIC INTERMITTENT HYPOXIA; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HEMATOCRIT; HYPERCAPNIA; HYPOXIA; MALE; NERVE CELL PLASTICITY; NONHUMAN; ORGAN SIZE; OXYGEN CONCENTRATION; PEAK INSPIRATORY FLOW; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; RESPIRATORY AIRFLOW; RESPIRATORY DRIVE; RESPIRATORY FAILURE; SEX DIFFERENCE; ANIMAL; ANOXIA; ARTICLE; LUNG VENTILATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SEXUAL DEVELOPMENT; TIME;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

ANIMALS; ANOXIA; FEMALE; HEMATOCRIT; HYPERCAPNIA; MALE; PULMONARY VENTILATION; RATS; SEX CHARACTERISTICS; TIME FACTORS;

EID: 67651211926     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-2259-2_38     Document Type: Conference Paper

References (21)

1. Behan, M., Zabka, A. G., Thomas, C. F., Mitchell, G. S. 2003, Sex steroid hormones and the neural control of breathing, Respir Physiol Neurobiol 136:249-63. (Pubitemid 36809011)
2. Bradford, A., McGuire, M., O'Halloran, K. D. 2005, Does episodic hypoxia affect upper airway dilator muscle function? Implications for the pathophysiology of obstructive sleep apnoea, Respir Physiol Neurobiol 147:223-34. (Pubitemid 41112741)
3. Dunleavy, M., Bradford, A., O'Halloran, K. D. 2008, Oxidative stress impairs upper airway muscle endurance in an animal model of sleep-disordered breathing, Adv Exp Med Biol 605:458-62.
4. Julien, C., Bairam, A., Joseph, V. 2008, Chronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats, Am J Physiol Regul Integr Comp Physiol 294:R1356-66. (Pubitemid 351490658)
5. 2 reserve in sleeping dogs, J Appl Physiol 103:1942-9. (Pubitemid 350232375)
6. McGuire, M., Zhang, Y., White, D. P., Ling, L. 2003, Chronic intermittent hypoxia enhances ventilatory long-term facilitation in awake rats, J Appl Physiol 95:1499-508. (Pubitemid 37169294)
7. O'Halloran, K. D., McGuire, M., O'Hare, T., Bradford, A. 2002, Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia, Chest 122:269-75. (Pubitemid 34754173)
8. O'Halloran, K. D., McGuire M, Bradford, A. 2007, Respiratory plasticity following chronic intermittent hypercapnic hypoxia in conscious rats. in Proceedings of the Joint Meeting of the Slovak Physiological Society, the Physiological Society and the Federation of European Physiological Societies, ed. V Strbak, Medimond S. r. l., Italy, pp. 99-103.
9. Pawar, A., Peng, Y. J., Jacono, F. J., Prabhakar, N. R. 2008, Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia, J Appl Physiol 104:1287-94.
10. Peng, Y. J., Overholt, J. L., Kline, D., Kumar, G. K., Prabhakar, N. R. 2003, Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas, Proc Natl Acad Sci USA 100:10073-8. (Pubitemid 37087069)
11. Peng, Y. J., Rennison, J., Prabhakar, N. R. 2004, Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups, J Appl Physiol 97:2020-5. (Pubitemid 39426026)
12. Ray, A. D., Magalang, U. J., Michlin, C. P., Ogasa, T., Krasney, J. A., Gosselin, L. E., Farkas, G. A. 2007, Intermittent hypoxia reduces upper airway stability in lean but not obese Zucker rats, Am J Physiol Regul Integr Comp Physiol 293:R372-8. (Pubitemid 47092196)
13. Rey, S., Del Rio, R., Alcayaga, J., Iturriaga, R. 2004, Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia, J Physiol 560:577-86. (Pubitemid 39440115)
14. Reeves, S. R., Gozal, D. 2004, Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice, Am J Physiol Regul Integr Comp Physiol 287:R369-74. (Pubitemid 38970290)
15. Reeves S. R., Gozal, D. 2006, Changes in ventilatory adaptations associated with long-term intermittent hypoxia across the age spectrum in the rat, Respir Physiol Neurobiol 150:135-43. (Pubitemid 43227452)
16. Reeves S. R., Gozal E., Guo S. Z., Sachleben, L. R. Jr, Brittian K. R., Lipton A. J., Gozal D. 2003, Effect of long-term intermittent and sustained hypoxia on hypoxic ventilatory and metabolic responses in the adult rat. J Appl Physiol. 95:1767-74. (Pubitemid 37310357)
17. Reeves, S. R., Guo, S. Z., Brittain K. R., Row, B. W., Gozal, D. 2006a, Anatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxia, Neurosci Lett 402:233-7. (Pubitemid 43850159)
18. Reeves, S. R., Mitchell, G. S., Gozal, D. 2006b, Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats, Am J Physiol Regul Integr Comp Physiol 290:R1664-71. (Pubitemid 43830833)
19. Skelly, J. R., Bradford A., O'Halloran, K. D. 2008, Tempol, a SOD-mimetic, improves muscle function in a rat model of sleep apnoea, Proc Physiol Soc, in press.
20. Veasey, S. C., Zhan, G., Fenik, P., Pratico, D. 2004, Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output, Am J Respir Crit Care Med 170:665-72. (Pubitemid 39202209)
21. Waters, K. A. and Tinworth, K. D. 2001, Depression of ventilatory responses after daily, cyclic hypercapnic hypoxia in piglets, J Appl Physiol 90:1065-73. (Pubitemid 32171396)