Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia

Journal of Applied Physiology

Volumn 104, Issue 5, 2008, Pages 1287-1294

  Pawar, Anita ^a,b   Peng, Ying Jie ^b   Jacono, Frank J ^a   Prabhakar, Nanduri R ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Glomus cells; Hyperplasia; Sensory long term facilitation

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAROTID BODY; CAROTID BODY CHEMORECEPTOR; CHEMORECEPTOR; CONTROLLED STUDY; HYPOXIA; MALE; MORPHOLOGY; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SENSITIZATION; SENSORY LONG TERM FACILITATION; SENSORY SYSTEM; SENSORY SYSTEM ELECTROPHYSIOLOGY; SLEEP APNEA SYNDROME; AGING; ANIMAL; ANOXIA; CHRONIC DISEASE; COMPARATIVE STUDY; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STATISTICAL ANALYSIS;

AGING; ANIMALS; ANIMALS, NEWBORN; ANOXIA; CAROTID BODY; CHEMORECEPTORS; CHRONIC DISEASE; DATA INTERPRETATION, STATISTICAL; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 45149086674     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00644.2007     Document Type: Article

References (32)

1. Bartolome J, Bartolome M, Seidler J, Anderson TR, Slotkin TA. Effects of early postnatal guanethidine administration on adrenal medulla and brain of developing rats. Biochem Pharmacol 25: 2387-2390, 1976.
2. Bisgard GE. Increase in carotid body sensitivity during sustained hypoxia. Biol Signals 4: 292-297, 1995.
3. Bisgard GE, Olson EB Jr, Wang ZY, Bavis RW, Fuller DD, Mitchell GS. Adult carotid body chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia. J Appl Physiol 95: 946-952, 2003.
4. Blanco CE, Dawes GS, Hanson MA, McCooke HB. The response to hypoxia of arterial chemoreceptors in fetal sheep and new-born lambs. J Physiol 351: 25-37, 1984.
5. Carroll JL. Developmental plasticity in respiratory control. J Appl Physiol 94: 375-389, 2003.
6. Cistulli PA, Sullivan CE. Pathophysiology of sleep apnea. In: Sleep and Breathing, edited by Saunders NA, Sullivan CE. New York: Dekker, 1994, p. 405-448.
7. Donnelly DF. Developmental aspects of oxygen sensing by the carotid body. J Appl Physiol 88: 2296-2301, 2000.
8. Erickson JT, Brosenitsch TA, Katz DM. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo. J Neurosci 21: 581-589, 2001.
9. Fidone SJ, Gonzalez C. Initiation and control of chemoreceptor activity in the carotid body. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 1, chapt. 9, p. 247-312.
10. Gagnon R, Campbell K, Hunse C, Patrick J. Patterns of human fetal heart rate accelerations from 26 weeks to term. Am J Obstet Gynecol 157: 743-748, 1987.
11. Gronblad M, Liesi P, Rechardt L. Serotonin-like immunoreactivity in rat carotid body. Brain Res 276: 348-350, 1983.
12. Kara T, Narkiewicz K, Somers VK. Chemoreflexes-physiology and clinical implications. Acta Physiol Scand 177: 377-384, 2003.
13. Kim I, Boyle KM, Carroll JL. Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells. J Appl Physiol 98: 1469-1477, 2005.
14. Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci USA 99: 821-826, 2002.
15. Lahiri S, Roy A, Baby SM, Hoshi T, Semenza GL, Prabhakar NR. Oxygen sensing in the body. Prog Biophys Mol Biol 91: 249-286, 2006.
16. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, Pickering TG. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283: 1829-1836, 2000.
17. Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci USA 100: 10073-10078, 2003.
18. Peng YJ, Prabhakar NR. Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol 96: 1236-1242, 2004.
19. Peng YJ, Rennison J, Prabhakar NR. Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups. J Appl Physiol 97: 2020-2025, 2004.
20. Peng YJ, Yuan G, Jacono FJ, Kumar GK, Prabhakar NR. 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. J Physiol 576: 289-295, 2006.
21. Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1 deficiency impairs carotid body-mediated cardio-respiratory responses and ROS generation in mice exposed to chronic intermittent hypoxia. J Physiol 577: 705-16, 2006.
22. Poets CF, Samuels MP, Southall DP. Epidemiology and pathophysiology of apnoea of prematurity. Biol Neonate 65: 211-219, 1994.
23. Prabhakar NR, Dick TE, Nanduri J, Kumar GK. Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia. Exp Physiol 92: 39-44, 2007.
24. Rey S, Del Rio R, Alcayaga J, Iturriaga R. Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia. J Physiol 560: 577-586, 2004.
25. 2 sensing by chemoreceptors. Pediatr Res 58: 53-57, 2005.
26. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, O'Connor GT, Boland LL, Schwartz JE, Samet JM. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 163: 19-25, 2001.
27. Sterni LM, Bamford OS, Wasicko MJ, Carroll JL. Chronic hypoxia abolished the postnatal increase in carotid body type I cell sensitivity to hypoxia. Am J Physiol Lung Cell Mol Physiol 277: L645-L652, 1999.
28. Villadiego J, Mendez-Ferrer S, Valdes-Sanchez T, Silos-Santiago I, Farinas I, Lopez-Barneo J, Toledo-Aral JJ. Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation. J Neurosci 25: 4091-4098, 2005.
29. Wang H, Yuan G, Prabhakar NR, Boswell M, Katz DM. Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling. J Neurochem 96: 694-705, 2006.
30. Wang ZY, Keith IM, Beckman MJ, Brownfield MS, Vidruk EH, Bisgard GE. 5-HT5a receptors in the carotid body chemoreception pathway of rat. Neurosci Lett 278: 9-12, 2000.
31. Wasicko MJ, Sterni LM, Bamford OS, Montrose MH, Carroll JL. Resetting and postnatal maturation of oxygen chemosensitivity in rat carotid chemoreceptor cells. J Physiol 514: 493-503, 1999.
32. Zhang M, Nurse CA. Does endogenous 5-HT mediate spontaneous rhythmic activity in chemoreceptor clusters of rat carotid body? Brain Res 872: 199-203, 2000.