A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of echinacoside and its pharmacokinetic application in rats

Biomedical Chromatography

Volumn 23, Issue 6, 2009, Pages 630-637

  Yang, Hao ^a   Wang, Guangji ^a   Hao, Haiping ^a   Tu, Pengfei ^b   Jiang, Yong ^b   Wang, Qiong ^a   Zhang, Yan ^a   Zheng, Chaonan ^a   Wang, Yuxin ^a   Dai, Liang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Antioxidant; Echinacoside; LC MS MS; Pharmacokinetics; Phenylethanoid glycoside

Indexed keywords

ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEGATIVE IONS; PHARMACOKINETICS; RATS;

ECHINACOSIDE; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; PHARMACOKINETIC STUDIES; PHENYLETHANOID GLYCOSIDES; RAPID METHOD; RAT PLASMA; SENSITIVE METHOD;

ANTIOXIDANTS;

ACETIC ACID; ACETONITRILE; ANTIOXIDANT; CHLOROGENIC ACID; ECHINACOSIDE; WATER; BUTANOL; GLYCOSIDE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; QUALITY CONTROL; RAT; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; CHEMISTRY; ECONOMICS; ELECTROSPRAY MASS SPECTROMETRY; MALE; METHODOLOGY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; TIME; VALIDATION STUDY;

RATTUS;

1-BUTANOL; ANIMALS; CHLOROGENIC ACID; CHROMATOGRAPHY, LIQUID; GLYCOSIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 67651209207     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1164     Document Type: Article

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