Systemic inhibition of the Na+/H+ exchanger type 3 in intact rats activates brainstem respiratory regions

Advances in Experimental Medicine and Biology

Volumn 648, Issue , 2009, Pages 395-401

  Pasaro, R ^a   Ribas Salgueiro, J L ^a   Matarredona, E R ^a   Sarmiento, M ^a   Ribas, J ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

c Fos immunohistochemistry; Central chemoreception; K lliker Fuse nucleus; Lateral parabrachial nucleus; Parapyramidal region; Pre B tzinger complex; Retrotrapezoid nucleus; Ventral respiratory column; Ventral respiratory group

Indexed keywords

AVE 1599; PROTEIN C FOS; PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3;

ANIMAL TISSUE; BRAIN REGION; CELL ACTIVATION; CELL COUNT; CELLS AND CELL COMPONENTS; CELLULAR DISTRIBUTION; CENTRAL INTERMEDIATE SUBSTANCE; CHEMORECEPTOR; CONFERENCE PAPER; CONTROLLED STUDY; EVOKED BRAIN STEM RESPONSE; NERVE CELL NETWORK; NERVE STIMULATION; NONHUMAN; PERIPHERAL NERVE; PONS; PRE BOTZINGER COMPLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; RESPIRATION CENTER; RETROTRAPEZOID NUCLEUS; ANIMAL; ARTICLE; BRAIN STEM; BREATHING; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALIA; RATTUS;

ANIMALS; BRAIN STEM; CHEMORECEPTOR CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; RESPIRATION; SODIUM-HYDROGEN ANTIPORTER;

EID: 67651205651     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-2259-2_45     Document Type: Conference Paper

References (24)

1. Abu-Shaweesh, J. M., Dreshaj, I. A., Martin, R. J., Wirth, K. J., Heinelt, U. & Haxhiu, M. A. 2002, Inhibition of Na (+)/H (+) exchanger type 3 reduces duration of apnea induced by laryngeal stimulation in piglets, Pediatr Res, 52:459-464. (Pubitemid 34920282)
2. Berquin, P., Bodineau, L., Gros, F. & Larnicol, N. 2000, Brainstem and hypothalamic areas involved in respiratory chemoreflexes: a Fos study in adult rats, Brain Res, 857:30-40. (Pubitemid 30107788)
3. Eldridge, F. L., Kiley, J. P. & Millhorn, D. E. 1984, Respiratory effects of carbon dioxide-induced changes of medullary extracellular fluid pH in cats, J Physiol 355:177-189. (Pubitemid 14044695)
4. Feldman, J. R., Mitchell, G. S. & Nattie, E. E. 2003, Breathing: rhythmicity, plasticity, chemosensitivity, Annu Rev Neurosci, 26:239-266. (Pubitemid 37064934)
5. Gaytan, S. P. & Pasaro, R. 1998, Connections of the rostral ventral respiratory neuronal cell group: an anterograde and retrograde tracing study in the rat, Brain Res Bull, 47:625-642. (Pubitemid 29115374)
6. Guyenet, P. G., Stornetta, R. L. & Bayliss, D. A. 2008, Retrotrapezoid nucleus and central chemoreception, J Physiol, 586:2043-2048. (Pubitemid 351524561)
7. Hilaire, G. & Pasaro, R. 2003, Genesis and control of the respiratory rhythm in adult mammals, News Physiol Sci, 18:23-28. (Pubitemid 36299379)
8. 2 response and lowers the apneic threshold. Am J Respir Crit Care Med, 164:1303-1311. (Pubitemid 33052267)
9. Mulkey, D., Stornetta, R. L., Weston, M. C., Simmons, J. R., Parker, A., Bayliss, D. A. & Guyenet, P. G. 2004, Respiratory control by ventral surface chemoreceptor neurons in rats, Nat Neurosci, 7:1360-1369. (Pubitemid 41057759)
10. Nattie, E. E. 2001, Chemoreception and tonic drive in the retrotrapezoid nucleus (RTN) region of the awake rat: bicuculline and muscimol dialysis in the RTN. Adv Exp Med Biol, 499:27-32. (Pubitemid 34087974)
11. Okada, Y., Chen, Z., Jiang, W., Kuwana, S. & Eldridge, F. L. 2002, Anatomical arrangement of hypercapnia-activated cells in the superficial ventral medulla of rats, J Appl Physiol, 93:427-439. (Pubitemid 34810201)
12. Paxinos, G. & Watson, C. 1997, The rat brain in stereotaxic coordinates, 3nd edn, Academic Press, Sydney.
13. +-sensitive neurons in the caudal ventrolateral medulla of the rat, J Physiol, 549:181-194. (Pubitemid 36626407)
14. + exchanger type 3, Auton Neurosci, 126/127:347-354. (Pubitemid 43816913)
15. Rosin, D. L., Chang, D. A. & Guyenet, P. G. 2006, Afferent and efferent connections of the rat retrotrapezoid nucleus, J Comp Neurol, 499:64-89. (Pubitemid 44423696)
16. + as central stimuli of respiration in the cat, J Appl Physiol, 58:357-364. (Pubitemid 15057743)
17. Smith, J. C., Abdala, A. P. L., Koizumi, H., Rybak, I. A. & Paton, J. F. R. 2007, Spatial and functional architecture of the mammalian brainstem respiratory network: a hierarchy of three oscillatory mechanisms, J Neurophysiol, 98:3370-3387.
18. Teppema, L. J., Barts, P. W., Folgering, H. T., Evers, J. A. 1983, Effects of respiratory and (isocapnic) metabolic arterial acid-base disturbances on medullary extracellular fluid pH and ventilation in cats. Respir Physiol, 53:379-95. (Pubitemid 13019699)
19. Teppema, L. J., Veening, J. G., Kranenburg, A., Dahan, A., Berkenbosch, A. & Olievier, C. 1997, Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia, J Comp Physiol, 388:169-190. (Pubitemid 27471495)
20. 2-sensitive medullary neurons: activation by intracellular acidification, Neuroreport, 9:167-170. (Pubitemid 28046676)
21. +-sensitive medullary neurons, Pflugers Arch, 438:255-262. (Pubitemid 29361743)
22. Wiemann, M., Frede, S., Bingmann, D., Kiwull, P. & Kiwull-Schone, H. 2005, Sodium/Proton exchanger 3 in the medulla oblongata and set point of breathing control. Am J Respir Crit Care Med, 172:244-249. (Pubitemid 40981201)
23. Wiemann, M., Piechatzek, L., Göpelt, K., Kiwull-Schöne, H., Kiwull, P. & Bingmann, D. 2008, The NHE3 inhibitor AVE1599 stimulates phrenic nerve activity in the rat, J Physiol Pharmacol, 59:27-36. (Pubitemid 351520160)
24. Wu, M., Haxhiu, M. A. & Johnson, S. M. 2005, Hypercapnic and hypoxic responses require intact neural transmission from the pre-Bötzinger complex, Respir Physiol Neurobiol, 146:33-46. (Pubitemid 40292709)