Different inflammatory mechanisms in lungs of severe and mild asthma: Crosstalk of NF-kappa-B, TGFβ1, Bax, Bcl-2, IL-4 and IgE

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 69, Issue 4, 2009, Pages 487-495

  Abdulamir, A S ^a,b,c   Hafidh, Rand Riadh ^a   Abubakar, Fatimah ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b AL NAHRAIN UNIVERSITY   (Iraq)

^c NONE   (Malaysia)

Author keywords

Allergy; apoptosis; atopy; BALF; cell survival; cytokines; ELISA; immunocytochemistry; inflammation; lymphocytes

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; PROTEIN BAX; PROTEIN BCL 2; TRANSFORMING GROWTH FACTOR BETA1;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; ASTHMA; CELL FREE SYSTEM; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATION; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 67651180808     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510902749131     Document Type: Article

References (44)

1. Bosse Y, Rola-Pleszczynski M. Controversy surrounding the increased expression of TGF beta 1 in asthma. Respir Res. 2007;8:66.
2. United States National Heart, Lung and Blood Institute. Available at: http://www.nhlbi.nih.gov/.
3. Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell. 1997;88:347-54.
4. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol. 2008;9:231-41.
5. Sturm A, de Souza HS, Fiocchi C. Mucosal T cell proliferation and apoptosis in inflammatory bowel disease. Curr Drug Targets. 2008;9:381-7.
6. Nevzorova VA, Suvorenko TN, Konovalova EN. Apoptosis and inflammation in bronchial asthma. Ter Arkh. 2001;73:92-6.
7. Duvernelle C, Freund V, Frossard N. Transforming growth factor-beta and its role in asthma. Pulm Pharmacol Ther. 2003;16:181-96.
8. Howell JE, McAnulty RJ. TGF-beta: its role in asthma and therapeutic potential. Curr Drug Targets. 2006;7:547-65.
9. Makinde T, Murphy RF, Agrawal DK. The regulatory role of TGFbeta in airway remodeling in asthma. Immunol Cell Biol. 2007.
10. Karagiannidis C, Hense G, Martin C, Epstein M, Ruckert B, Mantel PY, et al. Activin A is an acute allergen-responsive cytokine and provides a link to TGF-beta-mediated airway remodeling in asthma. J Allergy Clin Immunol. 2006;117:111-18.
11. Matsunaga K, Yanagisawa S, Ichikawa T, Ueshima K, Akamatsu K, Hirano T, Nakanishi M, Yamagata T, Minakata Y, Ichinose M. Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients. J Allergy Clin Immunol. 2006;118:84-90.
12. Balzar S, Chu HW, Silkoff P, Cundall M, Trudeau JB, Strand M, Wenzel S. Increased TGF-beta2 in severe asthma with eosinophilia. J Allergy Clin Immunol. 2005;115:110-17.
13. Torrego A, Hew M, Oates T, Sukkar M, Fan Chung K. Expression and activation of TGF-beta isoforms in acute allergen induced remodelling in asthma. Thorax. 2007;62:307-13.
14. Schmidt-Weber CB, Blaser K. The role of TGF-beta in allergic inflammation. Immunol Allergy Clin North Am. 2006;26:233-44.
15. Pereira SG, Oakley F. Nuclear factor-kappaB1: regulation and function. Int J Biochem Cell Biol. 2008;40:1425-30.
16. Christman JW, Sadikot RT, Blackwell TS. The role of nuclear factor-kappa B in pulmonary diseases. Chest. 2000;117:1482-7.
17. Wright JG, Christman J W. The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy. Am J Respir Med. 2003;2:211-19.
18. Kuperman DA, Schleimer RP. Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr Mol Med. 2008;8:384-92.
19. Isidoro-Garcia M, Davila I, Laffond E, Moreno E, Lorente F, Gonzalez-Sarmiento R: Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study. Clin Mol Allergy. 2005;3:15-20.
20. Yamaguchi E, Okazaki N, Tuneta Y, Abe S, Terai T, Kawakami Y. Interleukins in pulmonary sarcoidosis: dissociative correlations of lung interleukins 1 and 2 with the intensity of alveolitis. Am Rev Respir Dis. 1988;138:645-51.
21. Tsao TC, Chen CH, Hong JH, Hsieh MJ, Tsao KC, Lee CH. Shifts of T4/T8 T lymphocytes from BAL fluid and peripheral blood by clinical grade in patients with pulmonary tuberculosis. Chest. 2002;122:1285-91.
22. Schuurs A, Weeman V. Enzyme immunoassay. Clin Chem Acta. 1977;31:1-40.
23. Borish L, Culp JA. Asthma: a syndrome composed of heterogeneous diseases. Ann Allergy Asthma Immunol. 2008;101:8-11.
24. Walters EH, Bjermer L, Faurschou P, Sandstrom T. The anti-inflammatory profile of inhaled corticosteroids combined with salmeterol in asthmatic patients. Respir Med. 2000;94 Suppl F:S26-31.
25. Hansen G, Berry G, DeKrayf RH, Umetsu DT. Allergen specific Th1 cells fail to counterbalance Th2 cells induced airway hypereactivity but cause sever airway inflammation. J Clin Invest. 1999;103:175-83.
26. Pilette C, Ouadriri Y, Godding V, Vaerman JP, Sibille Y. Lung mucosal immunity: immunoglobulin-A revisited. Eur Respir J. 2001;18:571-88.
27. Kunkel EJ, Butcher EC. Plasma-cell homing. Nat Rev Immunol. 2003;3:822-9.
28. Herrmann JL, Beham AW, Sarkiss M, Chiao PJ, Rands MT, Bruckheimer EM, Brisbay S, McDonnell TJ. Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway. Exp Cell Res. 1997;237:101-9.
29. Chen GG, Liang NC, Lee JF, Chan UP, Wang SH, Leung BC, Leung KL. Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. Apoptosis. 2004;9:619-27.
30. Viatour P, Bentires-Alj M, Chariot A, Deregowski V, de Leval L, Merville MP, Bours V. NF-kappa B2/p100 induces Bcl-2 expression. Leukemia. 2003;17:1349-56.
31. El-Gamal Y, Heshmat N, Mahran M, El-Gabbas Z. Expression of the apoptosis inhibitor Bcl-2 in sputum eosinophils from children with acute asthma. Clin Exp Allergy. 2004;34:1701-6.
32. Jang AS, Choi IS, Lee S, Seo JP, Yang SW, Park CS. Bcl-2 expression in sputum eosinophils in patients with acute asthma. Thorax. 2000;55:370-4.
33. Warshamana GS, Corti M, Brody AR. TNF-alpha, PDGF, and TGF-beta(1) expression by primary mouse bronchiolaralveolar epithelial and mesenchymal cells: tnf-alpha induces TGF-beta(1). Exp Mol Pathol. 2001;71:13-33.
34. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA. Interleukin-13 induces tissue fi brosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med. 2001;194:809-21.
35. Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, la Rocca AM, Bellia V, Bonsignore G, Bousquet J. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med. 1997;156:591-9.
36. Coker RK, Laurent GJ, Shahzeidi S, Hernandez-Rodriguez NA, Pantelidis P, du Bois RM, Jeffery PK, McAnulty RJ. Diverse cellular TGFbeta 1 and TGF-beta 3 gene expression in normal human and murine lung. Eur Respir J. 1996;9:2501-7.
37. de Boer WI, van Schadewijk A, Sont JK, Sharma HS, Stolk J, Hiemstra PS, van Krieken JH. Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;158:1951-7.
38. Scherf W, Burdach S, Hansen G. Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model. Eur J Immunol. 2005;35:198-206.
39. Hansen G, McIntire JJ, Yeung VP, Berry G, Thorbecke GJ, Chen L, DeKruyff RH, Umetsu DT. CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyper reactivity and inflammation. J Clin Invest. 2000;105:61-70.
40. Berger P, Girodet PO, Manuel Tunon-de-Lara J. Mast cell myositis: a new feature of allergic asthma? Allergy. 2005;60:1238-40.
41. Gruber BL, Marchese MJ, Kew RR. Transforming growth factorbeta 1 mediates mast cell chemotaxis. J Immunol. 1994;152:5860-7.
42. Virchow JC, Kroegel C, Walker C, Matthys H. Inflammatory determinants of asthma severity: mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. J Allergy Clin Immunol. 1996;98:27-33.
43. Tillie-Leblond I, Pugin J, Marquette CH, Lamblin C, Saulnier F, Brichet A, Wallaert B, Tonnel AB, Gosset P. Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus. Am J Respir Crit Care Med. 1999;159:487-94.
44. Nichols TC, Fischer TH, Deliargyris EN, Baldwin AS. Role of nuclear factor-kappa B (NF-kappa B) in inflammation, periodontitis, and atherogenesis. Ann Periodontol. 2001;6:20-9.