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Determining the effect of highly active antiretroviral therapy on changes in human immunodeficiency virus type 1 RNA viral load using a marginal structural left-censored mean model
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Cole SR, Hernán MA, Anastos K, et al. Determining the effect of highly active antiretroviral therapy on changes in human immunodeficiency virus type 1 RNA viral load using a marginal structural left-censored mean model. Am J Epidemiol 2007; 166:219-227. This important study demonstrates the use of appropriate statistical methods (including methods to deal with time-varying confounding as well as changes in viral load detection limits over time) to assess the effect of HAART on virological outcomes when initiated at different CD4 cell count levels. (Pubitemid 47227283)
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3 is associated with improved survival [Abstract H-896b]. 48th ICAAC/46th IDSA, Washington DC, October 2008. Although only currently available as an abstract, this analysis is notable for using appropriate statistical methods to attempt to deal with several sources of bias that may be present in cohort studies.
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Kitahata, M.1
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Three types of adherence to HIV antiretroviral therapy and their association with AIDS diagnosis, medication side-effects, beliefs about antiretroviral therapy, and beliefs about HIV disease
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Adherence to both cotrimoxazole and placebo is associated with improved survival among HIV-infected Zambian children
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doi: 10.1007/s10461-008-9382-4. This study provides a very eloquent demonstration that variations in adherence to placebo in a study can have impacts on treatment outcomes that are comparable to the effects apparently attributable to pre-HAART CD4 cell count differences that are reported from cohort studies
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Walker AS, Ford D, Mulenga V, et al. Adherence to both cotrimoxazole and placebo is associated with improved survival among HIV-infected Zambian children. AIDS Behav 2008. doi: 10.1007/s10461-008-9382-4. This study provides a very eloquent demonstration that variations in adherence to placebo in a study can have impacts on treatment outcomes that are comparable to the effects apparently attributable to pre-HAART CD4 cell count differences that are reported from cohort studies.
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AIDS Behav
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Walker, A.S.1
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Mulenga, V.3
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