Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study

HIV Medicine

Volumn 9, Issue 6, 2008, Pages 397-405

  Wolbers, M ^a   Bucher, H C ^a,b   Furrer, H ^c   Rickenbach, M ^d,i   Cavassini, M ^d   Weber, R ^e,j   Schmid, P ^f,j   Bernasconi, E ^g   Hirschel, B ^h,i   Battegay, Manuel ^b   Boni J ^j   Burgisser P ^j   Calmy, A ^j   Cattacin, S ^j   Dubs, R ^j   Egger, M ^j   Elzi, L ^j   Erb, P ^j   Fischer, M ^j   Flepp, M ^j   Fontana, A ^j   Francioli, P ^d   Fux, C ^j   Gorgievski, M ^j   Gunthard H ^j   Hirsch, H ^j   Hosli I ^j   Kahlert, C ^j   Kaiser, L ^j   Karrer, U ^j   Kind, C ^j   Klimkait, T ^j   Ledergerber, B ^j   Martinetti, G ^j   Martinez, B ^j   Muller N ^j   Nadal, D ^j   Opravil, M ^j   Paccaud, F ⁱ   Pantaleo, G ^j   Rauch, A ^j   Regenass, S ^j   Rudin, C ^j   Schultze, D ^j   Schupbach J ^j   Speck, R ^j   Taffe P ^j   Tarr, P ^j   Telenti, A ^j   Trkola, A ^j   Vernazza, P ^j   Yerly, S ^j   more..

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^g REGIONAL HOSPITAL OF LUGANO   (Switzerland)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

ⁱ Data Centre

^j NONE

more..

Author keywords

Cohort study; Late ART initiation; Late HIV diagnosis; Late presentation

Indexed keywords

ANTIRETROVIRUS AGENT;

ADULT; AGE; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONTROLLED STUDY; DELAYED DIAGNOSIS; FEMALE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ABUSE; MAJOR CLINICAL STUDY; MALE; MALE HOMOSEXUAL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROBABILITY; RACE DIFFERENCE; RISK FACTOR; SEXUAL TRANSMISSION; SWITZERLAND; THERAPY DELAY;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTI-RETROVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; EARLY DIAGNOSIS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; RISK FACTORS; RNA, VIRAL; VIRAL LOAD;

EID: 47649094876     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/j.1468-1293.2008.00566.x     Document Type: Article

References (31)

1. DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents - a Working Group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Available at: http://www.aidsinfo.nih.gov
2. Hammer SM, Saag MS, Schechter M et al. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society - USA Panel. JAMA 2006; 296: 827-843.
3. Battegay M, Fluckiger U, Hirschel B, Furrer H. Late presentation of HIV-infected individuals. Antiviral Ther 2007; 12: 841-851.
4. Girardi E, Sabin CA, Monforte AD. Late diagnosis of HIV infection: epidemiological features, consequences and strategies to encourage earlier testing. J Acquir Immune Defic Syndr 2007; 46 (Suppl 1): S3-S8.
5. Gay CL, Napravnik S, Eron JJ Jr. Advanced immunosuppression at entry to HIV care in the southeastern United States and associated risk factors. AIDS 2006; 20: 775-778.
6. Klein D, Hurley LB, Merrill D, Quesenberry CP Jr. Review of medical encounters in the 5 years before a diagnosis of HIV-1 infection: implications for early detection. J Acquir Immune Defic Syndr 2003; 32: 143-152.
7. Gupta SB, Gilbert RL, Brady AR, Livingstone SJ, Evans BG. CD4 cell counts in adults with newly diagnosed HIV infection: Results of surveillance in England and Wales, 1990-1998. CD4 Surveillance Scheme Advisory Group. AIDS 2000; 14: 853-861.
8. Chadborn TR, Baster K, Delpech VC et al. No time to wait: How many HIV-infected homosexual men are diagnosed late and consequently die? (England and Wales, 1993-2002). AIDS 2005; 19: 513-520.
9. Chadborn TR, Delpech VC, Sabin CA, Sinka K, Evans BG. The late diagnosis and consequent short-term mortality of HIV-infected heterosexuals (England and Wales, 2000-2004). AIDS 2006; 20: 2371-2379.
10. Nakashima AK, Campsmith ML, Wolfe MI et al. Late versus early testing of HIV - 16 sites, United States, 2000-2003 (Reprinted from MMWR, vol 52, pg 583-586, 2003). JAMA 2003; 290: 455-457.
11. Samet JH, Freedberg KA, Savetsky JB, Sullivan LM, Stein MD. Understanding delay to medical care for HIV infection: The long-term non-presenter. AIDS 2001; 15: 77-85.
12. Castilla J, Sobrino P, de la Fuente L et al. Late diagnosis of HIV infection in the era of highly active antiretroviral therapy: consequences for AIDS incidence. AIDS 2002; 16: 1945-1951.
13. Delpierre C, Cuzin L, Lauwers-Cances V, Marchou B, Lang T. High-risk groups for late diagnosis of HIV infection: A need for rethinking testing policy in the general population. AIDS Patient Care STDS 2006; 20: 838-847.
14. Delpierre C, Dray-Spira R, Cuzin L et al. Correlates of late HIV diagnosis: Implications for testing policy. Int J STD AIDS 2007; 18: 312-317.
15. Dybul M, Bolan R, Condoluci D et al. Evaluation of initial CD4 T-cell counts in individuals with newly diagnosed human immunodeficiency virus infection, by sex and race, in urban settings. J Infect Dis 2002; 185: 1818-1821.
16. Girardi E, Aloisi MS, Arici C et al. Delayed presentation and late testing for HIV: Demographic and behavioral risk factors in a multicenter study in Italy. J Acquir Immune Defic Syndr 2004; 36: 951-959.
17. Hocking JS, Rodger AJ, Rhodes DG, Crofts N. Late presentation of HIV infection associated with prolonged survival following AIDS diagnosis - characteristics of individuals. Int J STD AIDS 2000; 11: 503-508.
18. Manavi K, McMillan A, Ogilvie M, Scott G. Heterosexual men and women with HIV test positive at a later stage of infection than homo- or bisexual men. Int J STD AIDS 2004; 15: 811-814.
19. Sabin CA, Smith CJ, Gumley H et al. Late presenters in the era of highly active antiretroviral therapy: Uptake of and responses to antiretroviral therapy. AIDS 2004; 18: 2145-2151.
20. Braitstein P, Brinkhof MW, Dabis F et al. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: Comparison between low-income and high-income countries. Lancet 2006; 367: 817-824.
21. Mocroft A, Ledergerber B, Katlama C et al. Decline in the AIDS and death rates in the EuroSIDA Study: An observational study. Lancet 2003; 362: 22-29.
22. Koenker R, Bassett G. Regression quantiles. Econometrica 1978; 46: 33-50.
23. R Foundation for Statistical Computing. R: A language and environment for statistical computing. Available at: http://www.R-project.org
24. Van Buuren S, Oudshoorn CGM. Multivariate Imputation by Chained Equations: MICE V1.0 User's Manual. Report PG/VGZ/00.038. Leiden: TNO Preventie en Gezondheid, 2000. Available at: http://www.multiple-imputation.com
25. Young J, de Geest S, Spirig R et al. Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV Cohort Study. BMJ 2004; 328: 15.
26. Egger M, May M, Chene G et al. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: A collaborative analysis of prospective studies. Lancet 2002; 360: 119-129.
27. Bassetti S, Battegay M, Furrer H et al. Why is highly active antiretroviral therapy (HAART) not prescribed or discontinued? Swiss HIV Cohort Study. J Acquir Immune Defic Syndr 1999; 21: 114-119.
28. Egger M. Outcomes of ART in resource-limited and industrialized countries. 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, CA, February 2007 [Abstract 62].
29. Delpierre C, Cuzin L, Lert F. Routine testing to reduce late HIV diagnosis in France. BMJ 2007; 334: 1354-1356.
30. Hamill M, Burgoine K, Farrell F et al. Time to move towards opt-out testing for HIV in the UK. BMJ 2007; 334: 1352-1354.
31. Dodds C, Weatherburn P. Reducing the length of time between HIV infection and diagnosis. BMJ 2007; 334: 1329-1330.