Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 4034-4043

  Kitabatake, Michikazu ^a   Nagai, Junko ^a   Abe, Kenji ^b   Tsuchiya, Yukihiro ^c   Ogawa, Keita ^a   Yokoyama, Takashi ^a   Mohri, Kunihiko ^a   Taguchi, Kyoji ^a   Horiguchi, Yoshie ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b OHU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

1,2,3,4 Tetrahydroisoquinoline; Cell protective effect; Cytotoxicity; Parkinson's disease; Pictet Spengler reaction; Propargyl group; Structure activity relationships

Indexed keywords

1 CYCLOPROPYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 METHYL N PROPARGYL 1,2,3,4 TETRAHYDROISOQUINOLINE; N PROPARGYL 1,2,3,4 TETRAHYDROISOQUINOLINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; NONHUMAN; PICTET SPENGLER REACTION; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; APOPTOSIS; CASPASES; CELL DEATH; MONOAMINE OXIDASE; MORPHINANS; PARKINSON DISEASE; PC12 CELLS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 67651149490     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.035     Document Type: Article

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