-
1
-
-
33646446894
-
VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells
-
Lin K, Perni RB, Kwong AD, et al. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells. Antimicrob Agents Chemother. 2006;50:1813-1822.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1813-1822
-
-
Lin, K.1
Perni, R.B.2
Kwong, A.D.3
-
2
-
-
33644639990
-
SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells
-
Malcolm BA, Liu R, Lahser F, et al. SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother. 2006;50: 1013-1020.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1013-1020
-
-
Malcolm, B.A.1
Liu, R.2
Lahser, F.3
-
3
-
-
33646449468
-
Discovery of SCH446211 (SCH6): A new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication
-
Bogen SL, Arasappan A, Bennett F. Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication. J Med Chem. 2006;49:2750-2757.
-
(2006)
J Med Chem
, vol.49
, pp. 2750-2757
-
-
Bogen, S.L.1
Arasappan, A.2
Bennett, F.3
-
4
-
-
34249081116
-
-
Prongay AJ, Guo Z, Yao N. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1, 1-dimethylethyl)amino]carbonyl] amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3- azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structurebased optimization. J Med Chem. 2007;50: 2310-2318.
-
Prongay AJ, Guo Z, Yao N. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1, 1-dimethylethyl)amino]carbonyl] amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3- azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structurebased optimization. J Med Chem. 2007;50: 2310-2318.
-
-
-
-
5
-
-
46949111215
-
Preclinical characterisitics of ITMN-B, an orally active inhibitor of the HCV NS3/4A protease nominated for preclinical development
-
Seiwert SD, Andrews SW, Tan H, et al. Preclinical characterisitics of ITMN-B, an orally active inhibitor of the HCV NS3/4A protease nominated for preclinical development. J Hepatol. 2006;44:S278.
-
(2006)
J Hepatol
, vol.44
-
-
Seiwert, S.D.1
Andrews, S.W.2
Tan, H.3
-
6
-
-
43249088693
-
Low response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C treated with abacavir
-
Vispo E, Barreiro P, Pineda JA, et al. Low response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C treated with abacavir. Antivir Ther. 2008;13: 429-437.
-
(2008)
Antivir Ther
, vol.13
, pp. 429-437
-
-
Vispo, E.1
Barreiro, P.2
Pineda, J.A.3
-
7
-
-
0032837102
-
Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group
-
Benhamou Y, Bochet M, Di Martino V, et al. Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group. Hepatology. 1999;30:1054-1058.
-
(1999)
Hepatology
, vol.30
, pp. 1054-1058
-
-
Benhamou, Y.1
Bochet, M.2
Di Martino, V.3
-
8
-
-
35748953422
-
-
De Francesco R, Carfi A. Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent rNA polymerase of the hepatitis C virus. Adv Drug Deliv Rev. 2007; 59:1242-1262. [e-pub August 11, 2007]. Review.
-
De Francesco R, Carfi A. Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent rNA polymerase of the hepatitis C virus. Adv Drug Deliv Rev. 2007; 59:1242-1262. [e-pub August 11, 2007]. Review.
-
-
-
-
9
-
-
47649116685
-
Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolates
-
Lopez-Labrador FX, Moya A, Gonzàles-Candelas F. Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolates. Antivir Ther. 2008;13:481-494.
-
(2008)
Antivir Ther
, vol.13
, pp. 481-494
-
-
Lopez-Labrador, F.X.1
Moya, A.2
Gonzàles-Candelas, F.3
-
10
-
-
52249086710
-
Mutation rate in hepatitis C virus NS3 protease is not influenced by HIV-1 protease inhibitor therapy
-
Halfon P, Bourliere M, Khiri G, et al. Mutation rate in hepatitis C virus NS3 protease is not influenced by HIV-1 protease inhibitor therapy. AIDS. 2008;22:1694-1696.
-
(2008)
AIDS
, vol.22
, pp. 1694-1696
-
-
Halfon, P.1
Bourliere, M.2
Khiri, G.3
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