Effects of flunixin meglumine on pyrexia and bioenergetic variables in postparturient dairy cows

Journal of Dairy Science

Volumn 92, Issue 5, 2009, Pages 1963-1970

  Shwartz, G ^a   Hill, K L ^b   VanBaale, M J ^a,c   Baumgard, L H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Natural Milk Dairy Company   (United States)

Author keywords

Flunixin meglumine; Metabolism; Pyrexia; Transition cow

Indexed keywords

ANIMALIA; BOS;

CLONIXIN; DRUG DERIVATIVE; FLUNIXIN MEGLUMINE; PROSTAGLANDIN RECEPTOR BLOCKING AGENT;

ANIMAL; ANIMAL DISEASE; ARTICLE; BODY TEMPERATURE; CATTLE; CATTLE DISEASE; CHEMISTRY; DAIRYING; DRUG EFFECT; EATING; ENERGY METABOLISM; FEMALE; FEVER; GLUCOSE BLOOD LEVEL; LACTATION; MILK; PHYSIOLOGY; PUERPERIUM; RANDOMIZATION; SECRETION; UREA NITROGEN BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; BODY TEMPERATURE; CATTLE; CATTLE DISEASES; CLONIXIN; DAIRYING; EATING; ENERGY METABOLISM; FEMALE; FEVER; LACTATION; MILK; POSTPARTUM PERIOD; PROSTAGLANDIN ANTAGONISTS; RANDOM ALLOCATION;

EID: 67651146558     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2008-1581     Document Type: Article

References (34)

1. Abramson, S. 1991. Therapy with and mechanisms of nonsteroidal anti-inflammatory drugs. Curr. Opin. Rheumatol. 3:336-340.
2. Amiridis, G. S., L. Leontides, E. Tassos, P. Kostoulas, and G. C. Fthenakis. 2001. Flunixin meglumine accelerates uterine involution and shortens the calving-to-first-oestrus interval in cows with puerperal metritis. J. Vet. Pharmacol. Ther. 24:365-367.
3. Anderson, K. L., and E. Hunt. 1989. Anti-inflammatory therapy in acute endotoxin-induced bovine mastitis. Vet. Res. Commun. 13:17-26.
4. 2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever. N. Engl. J. Med. 308:553-558.
5. Bondurant, R. H. 1999. Inflammation in the bovine female reproductive tract. J. Anim. Sci. 77(Suppl. 2):101-110.
6. Brander, G. C., D. M. Pugh, R. J. Bywater, and W. L. Jenkins. 1991. Veterinary Applied Pharmacology and Therapeutics. 5th ed. Bailliere Tindall, London, UK.
7. Dascanio, J. J., G. D. Mechor, Y. T. Grohn, D. G. Kenney, C. A. Booker, P. Thompson, C. L. Chiffelle, J. M. Musser, and L. D. Warnick. 1995. Effect of phenylbutazone and flunixin meglumine on acute toxic mastitis in dairy cows. Am. J. Vet. Res. 56:1213-1218.
8. Dinarello, C. A. 1984. Interleukin-1 and the pathogenesis of the acute phase response. N. Engl. J. Med. 311:1413-1418.
9. Drackley, J. K. 1999. Biology of dairy cows during the transition period: The final frontier? J. Dairy Sci. 82:2259-2273.
10. Drillich, M., D. Voigt, D. Forderung, and W. Heuwieser. 2007. Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment. J. Dairy Sci. 90:3758-3763.
11. Erb, R. E., and U. S. Ashworth. 1961. Relationships between age, body weight, and yield of dairy cows. J. Dairy Sci. 44:515-523.
12. 2+, and leukocytic pyrogen (interleukin-1). Fed. Proc. 43:1301-1306.
13. Hussain, A. M., and R. C. Daniel. 1991. Bovine endometritis: Current and future alternative therapy. Zentralbl. Veterinarmed. A 38:641-651.
14. Konigsson, K., H. Gustafsson, A. Gunnarsson, and H. Kindahl. 2001. Clinical and bacteriological aspects on the use of oxytetracycline and flunixin in primiparous cows with induced retained placenta and post-partal endometritis. Reprod. Domest. Anim. 36:247-256.
15. Kotler, D. P. 2000. Cachexia. Ann. Intern. Med. 133:622-634.
16. Lewis, G. S. 1997. Uterine health and disorders. J. Dairy Sci. 80:984-994.
17. Mallard, B. A., J. C. Dekkers, M. J. Ireland, K. E. Leslie, S. Sharif, C. L. Vankampen, L. Wagter, and B. N. Wilkie. 1998. Alteration in immune responsiveness during the peripartum period and its ramification on dairy cow and calf health. J. Dairy Sci. 81:585-595.
18. McCord, G. R., J. L. Cracowski, and C. T. Minson. 2006. Prostanoids contribute to cutaneous active vasodilation in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291:R596-R602.
19. Morteau, O. 2000. Prostaglandins and inflammation: The cyclooxygenase controversy. Arch. Immunol. Ther. Exp. (Warsz.) 48:473-480.
20. NRC. 2001. Nutrient Requirements of Dairy Cattle. 7th rev. ed. Natl. Acad. Press, Washington DC.
21. 2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls. J. Am. Acad. Dermatol. 47:28-32.
22. Neuwirth, J. G., J. K. Norton, C. A. Rawlings, F. N. Thompson, and G. O. Ware. 1979. Physiologic responses of dairy calves to environmental heat stress. Int. J. Biometeorol. 23:243-254.
23. Odens, L. J., R. Burgos, M. Innocente, M. J. VanBaale, and L. H. Baumgard. 2007. Effects of varying doses of supplemental CLA on production parameters and energetic variables during the transition period. J. Dairy Sci. 90:293-305.
24. 2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle. J. Biol. Chem. 257:1632-1638.
25. SAS Institute. 2005. SAS/STAT Users Guide. Release 9.3. SAS Inst. Inc., Cary, NC.
26. Semrad, S. D. 1993. Comparison of flunixin, prednisolone, dimethyl sulfoxide, and a lazaroid (U74389F) for treating endotoxemic neonatal calves. Am. J. Vet. Res. 54:1517-1522.
27. Sheldon, I. M., G. S. Lewis, S. LeBlanc, and R. O. Gilbert. 2006. Defining postpartum uterine disease in cattle. Theriogenology 65:1516-1530.
28. Sheldon, I. M., A. N. Rycroft, and C. Zhou. 2004. Association between postpartum pyrexia and uterine bacterial infection in dairy cattle. Vet. Rec. 154:289-293.
29. Soto, P., R. P. Natzke, and P. J. Hansen. 2003. Role of prostaglandins in the development of hyperthermia in heat-stressed, lactating Holstein cows. J. Vet. Pharmacol. Ther. 26:435-437.
30. Steiger, M., M. Senn, G. Altreuther, D. Werling, F. Sutter, M. Kreuzer, and W. Langhans. 1999. Effect of a prolonged low-dose lipopolysaccharide infusion on feed intake and metabolism in heifers. J. Anim. Sci. 77:2523-2532.
31. Takeuchi, Y., T. Kikusui, and Y. Mori. 1995. Changes in the behavioral parameters following the lipopolysaccharide administration in goats. J. Vet. Med. Sci. 57:1041-1044.
32. Tizard, I. R. 1996. Hypersensitivity. Pages 343-401 in Veterinary Immunology: An Introduction. 5th ed. W. B. Saunders Co., Philadelphia, PA.
33. Wagner, S. A., and M. D. Apley. 2004. Effects of two anti-inflammatory drugs on physiologic variables and milk production in cows with endotoxin-induced mastitis. Am. J. Vet. Res. 65:64-68.
34. Wildman, E. E., G. M. Jones, P. E. Wagner, R. L. Boman, H. F. Troutt Jr., and T. N. Lesch. 1982. A dairy cow body condition scoring system and its relationship to selected production characteristics. J. Dairy Sci. 65:495-501.