Ulmosides A and B: Flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4684-4687

  Rawat, Preeti ^a   Kumar, Manmeet ^a   Sharan, Kunal ^a   Chattopadhyay, Naibedya ^a   Maurya, Rakesh ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Differentiation; Flavonoid 6 C glycosides; Osteoblast; Osteogenic; Ulmus wallichiana

Indexed keywords

ALKALINE PHOSPHATASE; ANABOLIC AGENT; FLAVONOID GLYCOSIDE; PLANT EXTRACT; ULMOSIDE A; ULMOSIDE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BARK; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; ELM; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; RAT; STRUCTURE ACTIVITY RELATION; ULMUS WALLICHIANA;

ALKALINE PHOSPHATASE; ANIMALS; CELL DIFFERENTIATION; FLAVONOIDS; GLYCOSIDES; OSTEOBLASTS; PLANT BARK; PLANT STEMS; RATS; STEREOISOMERISM; ULMUS;

RATTUS; ULMUS WALLICHIANA;

EID: 67651123092     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.074     Document Type: Article

References (35)

1. Potter S.M., Baum J.A., Teng H., Stillman R.J., Shay N.F., and Erdmam Jr. J.W. Am. J. Clin. Nutr. 68 (1998) 1375S
2. Atkinson C., Composton J.E., Day N.E., Dowsett M., and Bingham S.A. Am. J. Clin. Nutr. 79 (2004) 326
3. Tamura G., Gold C., Fezz-Luzi A., and Ames B.N. Proc. Natl. Acad. Sci. U.S.A. 77 (1999) 4961
4. Horcajada-Molteni M.-N., Crespy V., Coxam V., Davicco M.-J., Remesy C., and Barlet J.-P. J. Bone Miner. Res. 15 (2000) 2251
5. Wattel A., Kamel S., Mentaverri R., Lorget F., Prouillet C., Petit J.-P., Fardelonne P., and Brazier M. Biochem. Pharmacol. 65 (2003) 35
6. Notoya M., Tsukamoto Y., Nishimura H., Woo J.-T., Nagai K., Lee I.-S., and Hagiwara H. Eur. J. Pharmacol. 485 (2004) 89
7. Khosla S., Westendoff J.J., and Oursler M.J. J. Clin. Invest. 118 (2008) 421
8. Jain S.K., and Dictionary of Indian Folk Medicine and Ethnobotany (1991), Deep Publications, Paschim Vihar, New Delhi, India p 183
9. Gaur R.D. Flora of District Garhwal, North West Himalaya (1999), Trans Media, Srinagar, Garhwal, India p 86
10. 2O-MeOH (9:1-1:1) as eluent.
11. Maurya, R.; Rawat, P.; Sharan, K.; Siddiqui, J. K.; Swarnkar, G.; Mishra, G.; Manickavasagam, L.; Jain, G. K.; Arya, K. R.; Chattopadhyay, N. PCT Patent no. PCT/IN2009/000146.
12. Lorente F.T., Ferreres F., and Barberan F.AB.T. Phytochemistry 21 (1982) 1461
13. Marais C., Rensburg W.J.v., Ferreira D., and Steenkamp J.A. Phytochemistry 55 (2000) 43
14. Chang B.S., Kwon W.C., and Kim C.M. Korean J. Pharmcogn. 35 (2004) 80
15. Fang N., Yu S., and Mabry T.J. Phytochemistry 25 (1986) 2684
16. Ramesh P., Nair A.G.R., and Subramanian S.S. Fitoterapia 57 (1986) 282
17. Mabry T.J., Markham K.R., and Thomas M.B. The Systemic Identification of Flavonoids (1970), Springer, New York
18. 12: C, 54.08; H, 4.75. Found: C, 54.01; H, 4.69.
19. Mbafor J.T., and Fomum Z.T. J. Nat. Prod. 52 (1989) 417
20. Gaffield W. Chem. Pharm. Bull. 44 (1996) 1102
21. Gaffield W. Tetrahedron 26 (1970) 4093
22. Nonaka G.I., Goto Y., Kinjo J.E., and Nohara I. Chem. Pharm. Bull. 35 (1987) 1105
23. Islam M.T., and Tahara S. Phytochemistry 54 (2000) 901
24. 11: C, 56.00; H, 4.92. Found: C, 56.02; H, 4.90.
25. Min-Won L. Saengyak Hakhoechi 25 (1994) 199
26. Min-Won L. Arch. Pharmacol. Res. 17 (1994) 487
27. Chin Y.W., Chai H.B., Keller W.J., and Kinghorn A.D. J. Agric. Food Chem. 56 (2008) 7759
28. Prescott A.G., Stamfoard N.P.J., Wheeler G., and Firmin J.L. Phytochemistry 60 (2002) 589
29. 10: C, 48.56; H, 5.24. Found: C, 48.70; H, 5.20.
30. Maurya R., Singh R., Deepak M., Handa S.S., Yadav P.P., and Mishra P.K. Phytochemistry 65 (2004) 915
31. 2 in air in α-MEM, supplemented with 10% fetal bovine serum (FBS), 2 mM glutamine, 100 U/ml penicillin-streptomycin, non-essential amino acid solution and sodium pyruvate. The medium was changed every alternate day. Test compounds were initially dissolved in DMSO and then diluted with serum-free medium, so that the final DMSO concentration was less than 0.1% in the conditioned medium.
32. Chattopadhyay N., Yano S., Hensen-Tfelt J., Roony P., Kunuparthi D., Bandyopadhyay S., Ren X., Terwilliger E., and Brown E.M. Endocrinology 145 (2004) 3451
33. 2, 1 mg/ml PNPP, pH 9.0), incubating in 37 °C, and absorbance (405 nm) was measured using a microplate spectrophotometer. Statistical significance was determined by paired two-tailed Student's t-tests.
34. Akiyama S., Katagiri T., Namiki M., Yamaji N., Yamamoto N., Miyama K., Shibuya H., Ueno N., Wozney J.M., and Suda T. Exp. Cell. Res. 235 (1997) 362
35. Dijke P. Curr. Med. Res. Opin. 22 (2006) S7