Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17α-hydroxylase/17,20-lyase (P-45017α)

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4698-4701

  Ahmed, Sabbir ^a   Shahid, Imran ^b   Dhanani, Sachin ^a   Owen, Caroline P ^a  

^a UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

^b KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

Hydroxylase; Inhibition; Lyase; Prostate cancer; Sulfonate

Indexed keywords

4 HYDROXYBENZYLIMIDAZOLE; ABIRATERONE ACETATE; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450C17; KETOCONAZOLE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MALE; NONHUMAN; RAT;

ANIMALS; ENZYME INHIBITORS; IMIDAZOLES; KETOCONAZOLE; MALE; RATS; STEROID 17-ALPHA-HYDROXYLASE; SULFONES; TESTIS;

RATTUS;

EID: 67651097821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.070     Document Type: Article

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12. 3S, calculated m/z 329.0954395.
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14. 50 was then determined from a graph (using linear regression analysis) of the inhibitory activity versus log [I].
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