Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α)

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 18, 2006, Pages 4752-4756

  Patel, Chirag H ^a   Dhanani, Sachin ^a   Owen, Caroline P ^a   Ahmed, Sabbir ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

17 Hydroxylase 17,20 lyase; Imidazole; Inhibitors; Prostate cancer

Indexed keywords

CYTOCHROME P450C17; IMIDAZOLE DERIVATIVE; KETOCONAZOLE;

ARTICLE; CHEMICAL INTERACTION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; EVALUATION; IC 50; ISOTOPE LABELING; SUBSTITUTION REACTION;

CYTOCHROME P-450 ENZYME SYSTEM; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROGESTERONE;

EID: 33746835743     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.06.092     Document Type: Article

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