Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α)

Journal of Steroid Biochemistry and Molecular Biology

Volumn 111, Issue 1-2, 2008, Pages 117-127

  Owen, Caroline P ^a   Shahid, Imran ^a   Olusanjo, Moniola S ^a   Patel, Chirag H ^a   Dhanani, Sachin ^a   Ahmed, Sabbir ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

17 Hydroxylase 17,20 lyase (P45017 ); Evaluation; Imidazole based inhibitors; Synthesis

Indexed keywords

1 (7 PHENYL HEPTYL) 1H IMIDAZOLE; 1 (8 PHENYL OCTYL) 1H IMIDAZOLE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; N 7 PHENYL HEPTYL IMIDAZOLE; N 8 PHENYL OCTYL IMIDAZOLE; PHENYL ALKYL IMIDAZOLE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

17-HYDROXYSTEROID DEHYDROGENASES; ENZYME INHIBITORS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; ISOENZYMES; KETOCONAZOLE; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE; RATIONALIZATION; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47849120938     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2008.05.007     Document Type: Article

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