메뉴 건너뛰기




Volumn 13, Issue 3, 2009, Pages 257-263

Fluoxetine and sertraline attenuate postischemic brain injury in mice

Author keywords

Cerebral blood flow autoregulation; Focal cerebral ischemia; Heme oxygenase 1; Hypoxia inducible factor 1 ; Selective serotonin reuptake inhibitors

Indexed keywords

FLUOXETINE; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SERTRALINE;

EID: 67651015248     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2009.13.3.257     Document Type: Article
Times cited : (49)

References (58)
  • 1
    • 4644259153 scopus 로고    scopus 로고
    • Cellular oxygen sensing need in CNS function: Physiological and pathological implications
    • DOI 10.1242/jeb.01075
    • Acker T, Acker H. Cellular oxygen sensing need in CNS function: physiological and pathological implications. J Exp Biol 207: 3171-3188, 2004. (Pubitemid 39275292)
    • (2004) Journal of Experimental Biology , vol.207 , Issue.18 , pp. 3171-3188
    • Acker, T.1    Acker, H.2
  • 2
    • 0027998431 scopus 로고
    • Incidence of post-stroke depression during the first year in a large unselected stroke population determined using a valid standardized rating scale
    • Andersen G, Vestergaard K, Riis J, Lauritzen L. Incidence of post-stroke depression during the first year in a large unselected stroke population determined using a valid standardized rating scale. Acta Psychiatr Scand 90: 190-195, 1994b. (Pubitemid 24291618)
    • (1994) Acta Psychiatrica Scandinavica , vol.90 , Issue.3 , pp. 190-195
    • Andersen, G.1    Vestergaard, K.2    Riis, J.O.3    Lauritzen, L.4
  • 4
    • 0022870943 scopus 로고
    • Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
    • Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17: 1304-1308, 1986.
    • (1986) Stroke , vol.17 , pp. 1304-1308
    • Bederson, J.B.1    Pitts, L.H.2    Germano, S.M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.M.6
  • 5
    • 0342660895 scopus 로고    scopus 로고
    • Vasogenic brain edema
    • Welch KMA, Caplan LR, Reis DJ, Siesj BK, Weir B, ed, San Diego: Academic Press
    • Betz AL. Vasogenic brain edema. In: Welch KMA, Caplan LR, Reis DJ, Siesj BK, Weir B, ed, Primer on cerebrovascular diseases. San Diego: Academic Press, p 56-159, 1997.
    • (1997) Primer on Cerebrovascular Diseases , pp. 56-159
    • Betz, A.L.1
  • 7
    • 23444438909 scopus 로고    scopus 로고
    • Heterocyclics and selective serotonin reuptake inhibitors in the treatment and prevention of poststroke depression
    • DOI 10.1111/j.1532-5415.2005.53310.x
    • Bhogal SK, Teasell R, Foley N, Speechley M. Heterocyclics and selective serotonin reuptake inhibitors in the treatment and prevention of post-stroke depression. J Am Geriatr Soc 53: 1051-1057, 2005. (Pubitemid 41647607)
    • (2005) Journal of the American Geriatrics Society , vol.53 , Issue.6 , pp. 1051-1057
    • Bhogal, S.K.1    Teasell, R.2    Foley, N.3    Speechley, M.4
  • 8
    • 0035126635 scopus 로고    scopus 로고
    • Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis
    • DOI 10.1006/exnr.2000.7456
    • Bidmon HJ, Emde B, Oermann E, Kubitz R, Witte OW, Zilles K. Heme oxygenase-1 (HSP-32) and heme oxygenase-2 induction in neurons and glial cells of cerebral regions and its relation to iron accumulation after focal cortical photothrombosis. Exp Neurol 168: 1-22, 2001. (Pubitemid 32195254)
    • (2001) Experimental Neurology , vol.168 , Issue.1 , pp. 1-22
    • Bidmon, H.-J.1    Emde, B.2    Oermann, E.3    Kubitz, R.4    Witte, O.W.5    Zilles, K.6
  • 9
    • 0028287265 scopus 로고
    • Current advances and trends in the treatment of depression
    • DOI 10.1016/0165-6147(94)90315-8
    • Blier P, de Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15: 220-226, 1994. (Pubitemid 24210726)
    • (1994) Trends in Pharmacological Sciences , vol.15 , Issue.7 , pp. 220-226
    • Blier, P.1    De Montigny, C.2
  • 10
    • 18244426740 scopus 로고    scopus 로고
    • Cerebral hypoperfusion in medication resistant, depressed patients assessed by Tc99m HMPAO SPECT
    • DOI 10.1016/S0165-0327(96)00058-4, PII S0165032796000584
    • Bonne O, Krausz Y, Gorfine M, Karger H, Gelfin Y, Shapira B, Chisin R, Lerer B. Cerebral hypoperfusion in medication resistant, depressed patients assessed by Tc99m HMPAO SPECT. J Affect Disord 41: 163-171, 1996. (Pubitemid 26422946)
    • (1996) Journal of Affective Disorders , vol.41 , Issue.3 , pp. 163-171
    • Bonne, O.1    Krausz, Y.2    Gorfine, M.3    Karger, H.4    Gelfin, Y.5    Shapira, B.6    Chisin, R.7    Lerer, B.8
  • 11
    • 0025748584 scopus 로고
    • Serotonergic innervation of the cerebral vasculature: Relevance to migraine and ischaemia
    • Bonvento G, MacKenzie ET, Edvinsson L. Serotonergic innervation of the cerebral vasculature: relevance to migraine and ischaemia. Brain Res Brain Res Rev 16: 257-263, 1991.
    • (1991) Brain Res Brain Res Rev , vol.16 , pp. 257-263
    • Bonvento, G.1    MacKenzie, E.T.2    Edvinsson, L.3
  • 12
    • 33645120961 scopus 로고    scopus 로고
    • Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell
    • Chiou SH, Chen SJ, Peng CH, Chang YL, Ku HH, Hsu WM, Ho LL, Lee CH. Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell. Biochem Biophys Res Commun 343: 391-400, 2006.
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 391-400
    • Chiou, S.H.1    Chen, S.J.2    Peng, C.H.3    Chang, Y.L.4    Ku, H.H.5    Hsu, W.M.6    Ho, L.L.7    Lee, C.H.8
  • 13
    • 0029972042 scopus 로고    scopus 로고
    • Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy
    • Dam M, Tonin P, De Boni A, Pizzolato G, Casson S, Ermani M, Freo U, Piron L, Battistin L. Effects of fluoxetine and maprotiline on functional recovery in post-stroke hemiplegic patients undergoing rehabilitation therapy. Stroke 27: 1211-1214, 1996. (Pubitemid 26226957)
    • (1996) Stroke , vol.27 , Issue.7 , pp. 1211-1214
    • Dam, M.1    Tonin, P.2    De Boni, A.3    Pizzolato, G.4    Casson, S.5    Ermani, M.6    Freo, U.7    Piron, L.8    Battistin, L.9
  • 14
    • 23744449508 scopus 로고    scopus 로고
    • HO-1 induction by HIF-1: A new mechanism for delayed cardioprotection?
    • Dawn B, Bolli R. HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection? Am J Physiol Heart Circ Physiol 289: H522-H524, 2005.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Dawn, B.1    Bolli, R.2
  • 18
    • 32144460313 scopus 로고    scopus 로고
    • Expression of heme oxygenase-1 protein and messenger RNA in permanent cerebral ischemia in rats
    • DOI 10.1179/016164106X91852
    • Fu R, Zhao ZQ, Zhao HY, Zhao JS, Zhu XL. Expression of heme oxygenase-1 protein and messenger RNA in permanent cerebral ischemia in rats. Neurol Res 28: 38-45, 2006. (Pubitemid 43204490)
    • (2006) Neurological Research , vol.28 , Issue.1 , pp. 38-45
    • Fu, R.1    Zhao, Z.Q.2    Zhao, H.Y.3    Zhao, J.S.4    Zhu, X.L.5
  • 19
  • 20
    • 0029971924 scopus 로고    scopus 로고
    • Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2 protein in rat brain
    • Geddes JW, Pettigrew LC, Holtz ML, Craddock SD, Maines MD. Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2 protein in rat brain. Neurosci Lett 210: 205-208, 1996.
    • (1996) Neurosci Lett , vol.210 , pp. 205-208
    • Geddes, J.W.1    Pettigrew, L.C.2    Holtz, M.L.3    Craddock, S.D.4    Maines, M.D.5
  • 21
    • 0023109436 scopus 로고
    • 1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat
    • 1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat. Psychopharmacology 91: 500-505, 1987.
    • (1987) Psychopharmacology , vol.91 , pp. 500-505
    • Goodwin, G.M.1    De Souza, R.J.2    Green, A.R.3
  • 22
    • 11444252736 scopus 로고    scopus 로고
    • New brain networks are active after right MCA stroke when moving the ipsilesional arm
    • Hanlon CA, Burlington AL, McKeown MJ. New brain networks are active after right MCA stroke when moving the ipsilesional arm. Neurology 64: 114-120, 2005.
    • (2005) Neurology , vol.64 , pp. 114-120
    • Hanlon, C.A.1    Burlington, A.L.2    McKeown, M.J.3
  • 23
    • 31344438217 scopus 로고    scopus 로고
    • Mechanisms of brain injury after global cerebral ischemia
    • DOI 10.1016/j.ncl.2005.10.004, PII S0733861905000848, Brain Injury and Cardiac Arrest
    • Harukuni I, Bhardwaj A. Mechanisms of brain injury after global cerebral ischemia. Neurol Clin 24: 1-21, 2006. (Pubitemid 43144627)
    • (2006) Neurologic Clinics , vol.24 , Issue.1 , pp. 1-21
    • Harukuni, I.1    Bhardwaj, A.2
  • 24
    • 0025864868 scopus 로고
    • A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments
    • Hensler JG, Kovachich GB, Frazer A. A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology 4: 131-144, 1991.
    • (1991) Neuropsychopharmacology , vol.4 , pp. 131-144
    • Hensler, J.G.1    Kovachich, G.B.2    Frazer, A.3
  • 26
    • 0036278051 scopus 로고    scopus 로고
    • Use of selective serotonin reuptake inhibitors and the risk of stroke: Is there reason for concern?
    • Jakovljevic D, Tuomilehto J. Use of selective serotonin reuptake inhibitors and the risk of stroke: is there reason for concern? Stroke 33: 1448-1449, 2002.
    • (2002) Stroke , vol.33 , pp. 1448-1449
    • Jakovljevic, D.1    Tuomilehto, J.2
  • 27
    • 0037046182 scopus 로고    scopus 로고
    • Inability to control anger or aggression after stroke
    • Kim JS, Choi S, Kwon SU, Seo YS. Inability to control anger or aggression after stroke. Neurology 58: 1106-1108, 2002. (Pubitemid 34298556)
    • (2002) Neurology , vol.58 , Issue.7 , pp. 1106-1108
    • Kim, J.S.1    Choi, S.2    Kwon, S.U.3    Seo, Y.S.4
  • 28
    • 0033006068 scopus 로고    scopus 로고
    • Post-stroke depression and functional recovery in a population-based stroke register. the Finnstroke study
    • Kotila M, Numminen H, Waltimo O, Kaste M. Post-stroke depression and functional recovery in a population-based stroke register. The Finnstroke study. Eur J Neurol 6: 309-312, 1999. (Pubitemid 29250990)
    • (1999) European Journal of Neurology , vol.6 , Issue.3 , pp. 309-312
    • Kotila, M.1    Numminen, H.2    Waltimo, O.3    Kaste, M.4
  • 29
    • 0029064827 scopus 로고
    • Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine
    • Kreiss DS, Lucki I. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine. J Pharmacol Exp Ther 274: 866-867, 1995.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 866-867
    • Kreiss, D.S.1    Lucki, I.2
  • 31
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    • DOI 10.1074/jbc.272.9.5375
    • Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AM. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 272: 5371-5381, 1997. (Pubitemid 27102353)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.9 , pp. 5375-5381
    • Lee, P.J.1    Jiang, B.-H.2    Chin, B.Y.3    Iyer, N.V.4    Alam, J.5    Semenza, G.L.6    Choi, A.M.K.7
  • 33
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554, 1997.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 34
    • 3042660266 scopus 로고    scopus 로고
    • Implications of adult hippocampal neurogenesis in antidepressant action
    • Malberg JE. Implications of adult hippocampal neurogenesis in antidepressant action. J Psychiatry Neurosci 29: 196-205, 2004. (Pubitemid 38829856)
    • (2004) Journal of Psychiatry and Neuroscience , vol.29 , Issue.3 , pp. 196-205
    • Malberg, J.E.1
  • 36
    • 0030805906 scopus 로고    scopus 로고
    • Effects of serotonin on cerebral circulation after middle cerebral artery occlusion
    • Muhonen MG, Robertson SC, Gerdes JS, Loftus CM. Effects of serotonin on cerebral circulation after middle cerebral artery occlusion. J Neurosurg 87: 301-306, 1997. (Pubitemid 27349118)
    • (1997) Journal of Neurosurgery , vol.87 , Issue.2 , pp. 301-306
    • Muhonen, M.G.1    Robertson, S.C.2    Gerdes, J.S.3    Loftus, C.M.4
  • 37
    • 0028273120 scopus 로고
    • The influence of age on stroke outcome. The Copenhagen Stroke Study
    • Nakayama H, Jorgensen HS, Raaschou HO, Olsen TS. The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke 25: 808-813, 1994.
    • (1994) Stroke , vol.25 , pp. 808-813
    • Nakayama, H.1    Jorgensen, H.S.2    Raaschou, H.O.3    Olsen, T.S.4
  • 38
    • 0029997537 scopus 로고    scopus 로고
    • Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia
    • DOI 10.1016/0169-328X(95)00315-J
    • Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR. Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia. Brain Res Mol Brain Res 37: 201-208, 1996. (Pubitemid 26147991)
    • (1996) Molecular Brain Research , vol.37 , Issue.1-2 , pp. 201-208
    • Nimura, T.1    Weinstein, P.R.2    Massa, S.M.3    Panter, S.4    Sharp, F.R.5
  • 40
    • 0032972686 scopus 로고    scopus 로고
    • Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice
    • Panahian N, Yoshiura M, Maines MD. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem 72: 1187-1203, 1999. (Pubitemid 29085035)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.3 , pp. 1187-1203
    • Panahian, N.1    Yoshiura, M.2    Maines, M.D.3
  • 43
    • 0023798653 scopus 로고
    • Post-stroke depression: A critical review of the literature
    • Primeau F. Post-stroke depression: a critical review of the literature. Can J Psychiatry 33: 757-765, 1988. (Pubitemid 18279785)
    • (1988) Canadian Journal of Psychiatry , vol.33 , Issue.8 , pp. 757-765
    • Primeau, F.1
  • 44
    • 0022333159 scopus 로고
    • Selective neuronal vulnerability: Morphological and molecular characteristics
    • Pulsinelli WA. Selective neuronal vulnerability: morphological and molecular characteristics. Prog Brain Res 63: 29-37, 1985.
    • (1985) Prog Brain Res , vol.63 , pp. 29-37
    • Pulsinelli, W.A.1
  • 45
    • 0038746804 scopus 로고    scopus 로고
    • Effect of depression on stroke morbidity and mortality
    • Ramasubbu R, Patten SB. Effect of depression on stroke morbidity and mortality. Can J Psychiatry 48: 250-257, 2003. (Pubitemid 36733832)
    • (2003) Canadian Journal of Psychiatry , vol.48 , Issue.4 , pp. 250-257
    • Ramasubbu, R.1    Patten, S.B.2
  • 47
    • 0037406908 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients
    • DOI 10.1176/appi.psy.44.3.216
    • Rasmussen A, Lunde M, Poulsen DL, Sørensen K, Qvitzau S, Bech P. A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics 44: 216-221, 2003. (Pubitemid 36514728)
    • (2003) Psychosomatics , vol.44 , Issue.3 , pp. 216-221
    • Rasmussen, A.1    Lunde, M.2    Poulsen, D.L.3    Sorensen, K.4    Qvitzau, S.5    Bech, P.6
  • 49
    • 4243550127 scopus 로고    scopus 로고
    • Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
    • DOI 10.1023/A:1015957026924
    • Ryter SW, Otterbein LE, Morse D, Choi AM. Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem 234-235: 249-263, 2002. (Pubitemid 34777864)
    • (2002) Molecular and Cellular Biochemistry , vol.234-235 , pp. 249-263
    • Ryter, S.W.1    Otterbein, L.E.2    Morse, D.3    Choi, A.M.K.4
  • 50
    • 0034852341 scopus 로고    scopus 로고
    • The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain
    • Sanchez V, Camarero J, Esteban B, Peter MJ, Green AR, Colado MI. The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. Br J Pharmacol 134: 46-57, 2001. (Pubitemid 32835467)
    • (2001) British Journal of Pharmacology , vol.134 , Issue.1 , pp. 46-57
    • Sanchez, V.1    Camarero, J.2    Esteban, B.3    Peter, M.J.4    Green, A.R.5    Colado, M.I.6
  • 51
    • 0037198374 scopus 로고    scopus 로고
    • Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: Characterization of inflammatory responses
    • DOI 10.1016/S0165-0270(02)00072-9, PII S0165027002000729
    • Schroeter M, Jander S, Stoll G. Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: characterization of inflammatory responses. J Neurosci Methods 117: 43-49, 2002. (Pubitemid 34663898)
    • (2002) Journal of Neuroscience Methods , vol.117 , Issue.1 , pp. 43-49
    • Schroeter, M.1    Jander, S.2    Stoll, G.3
  • 52
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
    • DOI 10.1016/S1471-4914(01)02090-1
    • Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 7: 345-350, 2001. (Pubitemid 32735019)
    • (2001) Trends in Molecular Medicine , vol.7 , Issue.8 , pp. 345-350
    • Semenza, G.L.1
  • 53
    • 0033803047 scopus 로고    scopus 로고
    • Surviving ischemia: Adaptive responses mediated by hypoxia-inducible factor 1
    • Semenza GL. Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest 106: 809-812, 2000.
    • (2000) J Clin Invest , vol.106 , pp. 809-812
    • Semenza, G.L.1
  • 54
    • 0024534360 scopus 로고
    • Affective disorders and cerebral vascular disease
    • Starkstein SE, Robinson RG. Affective disorders and cerebral vascular disease. Br J Psychiatry 154: 170-182, 1989.
    • (1989) Br J Psychiatry , vol.154 , pp. 170-182
    • Starkstein, S.E.1    Robinson, R.G.2
  • 56
    • 0023856405 scopus 로고
    • Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence
    • Uyama O, Okamura N, Yanase M, Narita M, Kawabata K, Sugita M. Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence. J Cereb Blood Flow Metab 8: 282-284, 1988. (Pubitemid 18079698)
    • (1988) Journal of Cerebral Blood Flow and Metabolism , vol.8 , Issue.2 , pp. 282-284
    • Uyama, O.1    Okamura, N.2    Yanase, M.3    Narita, M.4    Kawabata, K.5    Sugita, M.6
  • 58
    • 0017625807 scopus 로고
    • Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine
    • Welch KM, Chabi E, Buckingham J, Bergin B, Achar VS, Meyer JS. Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine. Stroke 8: 341-346, 1977.
    • (1977) Stroke , vol.8 , pp. 341-346
    • Welch, K.M.1    Chabi, E.2    Buckingham, J.3    Bergin, B.4    Achar, V.S.5    Meyer, J.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.