Alterations in rat serum proteome and metabolome as putative disease markers in sepsis

Journal of Trauma - Injury, Infection and Critical Care

Volumn 66, Issue 4, 2009, Pages 1065-1075

  Hinkelbein, Jochen ^a,b   Feldmann Jr , Robert E ^b   Schubert, Charlotte ^a,b   Peterka, Anna ^a,b   Schelshorn, Dominik ^b   Maurer, Martin H ^b,c   Kalenka, Armin ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c SYGNIS Bioscience   (Germany)

Author keywords

Coecal ligature and puncture; Protein expression; Proteomics; Rat serum; Sepsis

Indexed keywords

PROTEOME; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; MALE; METABOLOME; MORTALITY; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; SEPSIS; TWO DIMENSIONAL GEL ELECTROPHORESIS; ANIMAL; BLOOD; DISEASE MODEL; GENETICS; IMAGE PROCESSING; PEPTIDE MAPPING; PHYSIOLOGY; WISTAR RAT;

ACUTE-PHASE PROTEINS; ANIMALS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; METABOLOME; PEPTIDE MAPPING; PROTEOME; RATS; RATS, WISTAR; SEPSIS;

EID: 67651009426     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181958ad7     Document Type: Article

References (55)

1. Fink MP, Heard SO. Laboratory models of sepsis and septic shock. J Surg Res. 1990;49:186-196. (Pubitemid 20241651)
2. Dellinger RP, Carlet JM, Masur H, et al. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2004;30:536-555. (Pubitemid 38541501)
3. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-1554.
4. Hinkelbein J, Feldmann RE Jr, Peterka A, et al. Alterations in cerebral metabolomics and proteomic expression during sepsis. Curr Neurovasc Res. 2007;4:280-288. (Pubitemid 350171829)
5. Hinkelbein J, Schroeck H, Peterka A, Schubert C, Kuschinsky W, Kalenka A. Local cerebral blood flow is preserved in sepsis. Curr Neurovasc Res. 2007;4:39-47. (Pubitemid 46280290)
6. Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res. 1980;29:189-201.
7. Hubbard WJ, Choudhry M, Schwacha MG, et al. Cecal ligation and puncture. Shock. 2005;24:52-57.
8. Kalenka A, Hinkelbein J, Feldmann RE Jr, Kuschinsky W, Waschke KF, Maurer MH. The effects of sevoflurane anesthesia on rat brain proteins: a proteomic time-course analysis. Anesth Analg. 2007;104:1129-1135. (Pubitemid 46649933)
9. Kalenka A, Feldmann RE Jr, Otero K, Maurer MH, Waschke KF, Fiedler F. Changes in the serum proteome of patients with sepsis and septic shock. Anesth Analg. 2006;103:1522-1526. (Pubitemid 44949223)
10. Bradford MM. A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
11. Weinkauf M, Hiddemann W, Dreyling M. Sample pooling in 2-D gel electrophoresis: a new approach to reduce nonspecific expression background. Electrophoresis. 2006;27:4555-4558. (Pubitemid 44869610)
12. Schlags W, Walther M, Masree M, Kratzel M, Noe CR, Lachmann B. Towards validating a method for two-dimensional electrophoresis/silver staining. Electrophoresis. 2005;26:2461-2469. (Pubitemid 40932753)
13. Perkins D, Pappin D, Creasy D, Cottrell JS. Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis. 1999;20:3551-3567. (Pubitemid 30007252)
14. Maurer MH. Comparison of large proteomic datasets. Curr Proteomics. 2005;2:179-189.
15. Feldmann RE Jr, Maurer MH, Hunzinger C, et al. Reduction in rat phosphatidyl ethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study. Stress. 2008;11:134-147. (Pubitemid 351323434)
16. Anderson L, Seilhamer J. A comparison of selected mRNA and protein abundances in human liver. Electrophoresis. 1997;18:533-537. (Pubitemid 27174443)
17. Anderson N, Anderson N. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002;1:845-867.
18. Rittirsch D, Hoesel LM, Ward PA. The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol. 2007;81:137-143. (Pubitemid 46021262)
19. Chaudry IH, Wichterman KA, Baue AE. Effect of sepsis on tissue adenine nucleotide levels. Surgery. 1979;85:205-211. (Pubitemid 9097866)
20. McDunn JE, Townsend RR, Cobb JP. The murine plasma protein response to polymicrobial intra-abdominal sepsis. Proteomics Clin Appl. In press. doi: 10.1002/prca. 200600494.
21. Hall RE, Blaese RM, Davis AE III, et al. Cooperative interaction of factor B and other complement components with mononuclear cells in the antibody-independent lysis of xenogeneic erythrocytes. J Exp Med. 1982;156:834-843.
22. Sundsmo JS, Gotze O. Human monocyte spreading induced by activated factor B of the complement alternative pathway: differential effects of Fab′ and F(ab′)2 antibody fragments directed to C5, C6, and C7. Cell Immunol. 1983;77:176-186.
23. Peters MG, Ambrus JL Jr., Fauci AS, et al. The Bb fragment of complement factor B acts as a B cell growth factor. J Exp Med. 1988;168:1225-1235. (Pubitemid 18264861)
24. Ingenuity pathway analysis. Available at: http://www.ingenuity.com. Accessed September 30, 2008.
25. Zhao X, Tang R, Xiao Z, et al. An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis. Int J Neuropsychopharmacol. 2006;9:705-712. (Pubitemid 46122770)
26. Vincent P, Collette Y, Marignier R, et al. A role for the neuronal protein collapsin response mediator protein 2 in T lymphocyte polarization and migration. J Immunol. 2005;175:7650-7660. (Pubitemid 41713465)
27. Vuaillat C, Varrin-Doyer M, Bernard A, et al. High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation. J Neuroimmunol. 2008;193:38-51.
28. Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr Med Chem. 2007;14:2925-2936. (Pubitemid 350201659)
29. Ceydeli A, Condon MR, Siegel JH. The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell death. Shock. 2003;20:74-84.
30. Ruot B, Breuillé D, Rambourdin F, Bayle G, Capitan P, Obled C. Synthesis rate of plasma albumin is a good indicator of liver albumin synthesis in sepsis. Am J Physiol Endocrinol Metab. 2000;279:E244-E251. (Pubitemid 30672700)
31. Ramsey CP, Glass CA, Montgomery MB, et al. Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol. 2007;66:75-85.
32. Zanata SM, Lopes MH, Mercadante AF, et al. Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. EMBO J. 2002;21:3307-3316.
33. Crouser ED, Julian MW, Huff JE, Mandich DV, Green-Church KB. A proteomic analysis of liver mitochondria during acute endotoxemia. Intensive Care Med. 2006;32:1252-1262.
34. Chang AY, Chan JY, Chou JL, Li FC, Dai KY, Chan SH. Heat shock protein 60 in rostral ventrolateral medulla reduces cardiovascular fatality during endotoxaemia in the rat. J Physiol. 2006;574:547-564.
35. Vachharajani V, Russell JM, Scott KL, et al. Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brain. Microcirculation. 2005;12:183-194. (Pubitemid 40485631)
36. Chan SYH, Cheng HL, Chou JLJ, et al. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death. J Biol Chem. 2007;282:4585-4600.
37. Chien HF, Yeh KY, Jiang-Shieh F, et al. Signal transduction pathways of nitric oxide release in primary microglial culture challanged with gram-positive bacterial constituent, lipoteichoic acid. Neuroscience. 2005;133:423-436.
38. Quintana E, Hernández C, Moran AP, Esplugues JV, Barrachina MD. Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia. Life Sci. 2005;77:1044-1054. (Pubitemid 40814639)
39. Fink MP. Cytopathic hypoxia. Crit Care Clin. 2001;17:219-237.
40. Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L, Heneka MT. Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neuroanat. 2005;30:144-157. (Pubitemid 41338695)
41. Messaris E, Memos N, Chatzigianni E, et al. Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis. Crit Care Med. 2004;32:1764-1770. (Pubitemid 39050530)
42. Berbée JFP, Havekes LM, Rensen PCN. Apolipoproteins modulate the inflammatory response to lipopolysaccharide. J Endotoxin Res. 2005;11:97-103.
43. Voisin L, Breuillé D, Ruot B, et al. Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats. Am J Physiol. 1998;275:R1412-R1419. (Pubitemid 28539002)
44. Rothschild MA, Oratz M, Schreiber SS. Serum albumin. Hepatology. 1988;8:385-401.
45. Piñeiro M, Andrés M, Iturralde M, et al. ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection. Infect Immun. 2004;72:3777-3782. (Pubitemid 38821889)
46. Josic D, Brown MK, Huang F, et al. Proteomic characterization of inter-alpha inhibitor proteins from human plasma. Proteomics. 2006;6:2874-2885. (Pubitemid 43752047)
47. Liu D, Lu F, Qin G, Fernandes SM, Li J, Davis AE III. C1 inhibitor-mediated protection from sepsis. J Immunol. 2007;179:3966-3972.
48. Dobryszycka W. Biological functions of haptoglobin-new pieces to an old puzzle. Eur J Clin Chem Clin Biochem. 1997;35:647-654. (Pubitemid 27453361)
49. Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann H, Ceuppens JL. Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology. 2005;114:263-271. (Pubitemid 40208942)
50. Ren Y, Wang J, Jiang C, et al. The alterations of mouse plasma proteins during septic development. J Proteome Res. 2007;6:2812-2821. (Pubitemid 47122375)
51. Bazel S, Andrejko KM, Chen J, Deutschman CS. Hepatic gene expression and cytokine responses to sterile inflammation: comparison with cecal ligation and puncture sepsis in the rat. Shock. 1999;11:347-355.
52. Ebdrup L, Krog J, Granfeldt A, et al. Leukocyte, plasma, and organ-associated cytokine profiles in an animal model of acute inflammation. APMIS. 2008;116:352-360. (Pubitemid 351623875)
53. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008;34:17-60.
54. Bengmark S. Modulation by enteral nutrition of the acute phase response and immune functions. Nutr Hosp. 2003;18:1-5.
55. Rivers EP, Kruse JA, Jacobsen G, et al. The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock. Crit Care Med. 2007;35:2016-2024. (Pubitemid 47326436)