Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP

Analytical Biochemistry

Volumn 393, Issue 1, 2009, Pages 1-7

  Park, Je Won ^a   Mo, Sang Joon ^a   Park, Sung Ryeol ^a   Ban, Yeon Hee ^a   Yoo, Young Ji ^a   Yoon, Yeo Joon ^a  

^a Ewha Womans University   (South Korea)

Author keywords

FK506 profiling; Liquid chromatography mass spectrometry (LC MS); Tacrolimus

Indexed keywords

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CELL CULTURE; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLITES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE SEPARATION;

FK506 PROFILING; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY ELECTROSPRAY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE(NMR); SOLID PHASE EXTRACTION TECHNIQUES; STREPTOMYCES CLAVULIGERUS; TACROLIMUS;

EXTRACTION;

37,38 DIHYDROXYTACROLIMUS; 9 DECARBONYL 9 HYDROXYTACROLIMUS; 9 DEOXOASCOMYCIN; 9 DEOXOTACROLIMUS; ASCOMYCIN; FK 525; MACROLIDE; NORASCOMYCIN; PROLYLASCOMYCIN; PROLYLTACROLIMUS; TACROLIMUS; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BACTERIAL STRAIN; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FERMENTATION MEDIUM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RELIABILITY; SOLID PHASE EXTRACTION; STREPTOMYCES CLAVULIGERUS; STRUCTURE ANALYSIS;

BACTERIA (MICROORGANISMS); STREPTOMYCES CLAVULIGERUS;

EID: 67651004256     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2009.06.021     Document Type: Article

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