Depletion of embryonic stem cell signature by histone deacetylase inhibitor in NCCIT cells: Involvement of Nanog suppression

Cancer Research

Volumn 69, Issue 14, 2009, Pages 5716-5725

  Jueng, Soo You ^a   Jae, Ku Kang ^b   Seo, Dong Wan ^c   Jae, Hyun Park ^a   Jong, Woo Park ^a   Jae, Cheol Lee ^a   Yae, Jee Jeon ^a   Eun, Jung Cho ^a   Han, Jeung Whan ^a  

^a Sungkyunkwan University   (South Korea)

^b Konyang University   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APICIDIN; OCTAMER TRANSCRIPTION FACTOR 4; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CBP; TRANSCRIPTION FACTOR DNMT3B; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR GCNF; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ECTODERM; EMBRYONAL CARCINOMA STEM CELL; EMBRYONIC STEM CELL; ENDODERM; GENE EXPRESSION; HUMAN; HUMAN CELL; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL;

APOPTOSIS; BINDING SITES; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; EMBRYONAL CARCINOMA STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; PEPTIDES, CYCLIC; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION FACTORS;

EID: 67651003097     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-4953     Document Type: Article

References (37)

1. Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902.
2. Polyak K, Hahn WC. Roots and stems: stem cells in cancer. Nat Med 2006;12:296-300.
3. Liu R, Wang X, Chen GY, et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007;356:217-26.
4. Cho RW, Clarke MF. Recent advances in cancer stem cells. Curr Opin Genet Dev 2008;18:48-53.
5. Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005;122:947-56.
6. Sperger JM, Chen X, Draper JS, et al. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A 2003;100:13350-5.
7. Nichols J, Zevnik B, Anastassiadis K, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998;95:379-91.
8. Abate-Shen C. Homeobox genes and cancer: new OCTaves for an old tune. Cancer Cell 2003;4:329-30.
9. Chambers I, Colby D, Robertson M, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-55.
10. Liu N, Lu M, Tian X, Han Z. Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol 2007;211:279-86.
11. Darr H, Mayshar Y, Benvenisty N. Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. Development 2006;133:1193-201.
12. Tanaka Y, Era T, Nishikawa S-i, Kawamata S. Forced expression of Nanog in hematopoietic stem cells results in a γδT-cell disorder. Blood 2007;110:107-15.
13. Chiou S-H, Yu C-C, Huang C-Y, et al. Positive correlations of Oct-4 and Nanog in oral cancer stemlike cells and high-grade oral squamous cell carcinoma. Clin Cancer Res 2008;14:4085-95.
14. Ben-Porath I, Thomson MW, Carey VJ, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499-507.
15. Chen S, Do JT, Zhang Q, et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A 2006;103:17266-71.
16. Park JS, Lee KR, Kim JC, Lim SH, Seo JA, Lee YW. A hemorrhagic factor (apicidin) produced by toxic Fusarium isolates from soybean seeds. Appl Environ Microbiol 1999;65:126-30.
17. Sawyers C. Targeted cancer therapy. Nature 2004;432: 294-7.
18. Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008;132:661-80.
19. Cip1 and gelsolin. Cancer Res 2000;60:6068-74.
20. Deb-Rinker P, Ly D, Jezierski A, Sikorska M, Walker PR. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem 2005;280: 6257-60.
21. Li B, Carey M, Workman JL. The role of chromatin during transcription. Cell 2007;128:707-19.
22. Pan G, Thomson JA. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res 2007;17:42-9.
23. Gu P, LeMenuet D, Chung ACK, Mancini M, Wheeler DA, Cooney AJ. Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation. Mol Cell Biol 2005;25:8507-19.
24. Blume SW, Snyder RC, Ray R, Thomas S, Koller CA, Miller DM. Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J Clin Invest 1991;88:1613-21.
25. Przyborski SA, Christie VB, Hayman MW, Stewart R, Horrocks GM. Human embryonal carcinoma stem cells: models of embryonic development in humans. Stem Cells Dev 2004;13:400-8.
26. Ohm JE, McGarvey KM, Yu X, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007;39:237-42.
27. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414: 105-11.
28. Schulz WA, Hoffmann MJ. Transcription factor networks in embryonic stem cells and testicular cancer and the definition of epigenetics. Epigenetics 2007;2:37-42.
29. Greber B, Lehrach H, Adjaye J. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol 2007;7:46.
30. Surani MA, Hayashi K, Hajkova P. Genetic and epigenetic regulators of pluripotency. Cell 2007;128:747-62.
31. Atkinson S, Armstrong L. Epigenetics in embryonic stem cells: regulation of pluripotency and differentiation. Cell Tissue Res 2008;331:23-9.
32. Vire E, Brenner C, Deplus R, et al. The polycomb group protein EZH2 directly controls DNA methylation. Nature 2006;439:871-4.
33. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 2002;3:662-73.
34. Lin T, Chao C, Saito Si, et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2005;7:165-71.
35. Baltus GA, Kowalski MP, Tutter AV, Kadam S. A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2. J Biol Chem 2009;284:6998-7006.
36. Wu DY, Yao Z. Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter. Cell Res 2006;16:319-22.
37. Li Y, Kimura T, Huyck RW, Laity JH, Andrews GK. Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1. Mol Cell Biol 2008;28:4275-84.