Screening novel HIV-1 protease inhibitors based on the Substrate Envelope Hypothesis

Acta Chimica Sinica

Volumn 67, Issue 10, 2009, Pages 1098-1102

  Miao, Youpan ^a   Li, Aixiu ^a   Liu, Tao ^a   Wu, Kezhu ^a   Ma, Yi ^b  

^a MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

HIV 1 protease inhibitor; Molecular docking; Molecular dynamics simulation; Pharmacophore; Substrate envelope hypothesis

Indexed keywords

EID: 67650974112     PISSN: 05677351     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. De-Clercq E. J. Med. Chem. 2005 48 1297.
2. Svicher V., Ceccherini-Silberstein F., Erba F., Santoro M., Gori C., Bellocchi M. C., Giannella S., Trotta M. P., Monforte A., Antinori A., Perno C. F. Antimicrob. Agents Chemother. 2005 49 2015.
3. Prabu-Jeyabalan M., Nalivaika E. A., Schiffer C. A. Structure 2002 10 369.
4. King N. M., Prabu-Jeyabalan M., Nalivaika E. A., Schiffer C. A. Chem. Biol. 2004 11 1333.
5. Prabu-Jeyabalan M., Nalivaika E. A., King N. M., Schiffer C. A. J. Virol. 2003 77 1306.
6. Qiao X.-B., Hou T.-J., Zhang W., Guo S.-L., Xu X.-J. J. Chem. Inf. Comput. Sci. 2002 42 481.
7. Zhou J.-J., Xie G.-R., Yan X.-J. Traditional Chinese Medicines: Molecular Structures, Natural Sources and Applications, 2004 (in Chinese).
8. FDA approves Darunavir on June 23, 2006: FDA approved new HIV treatment for patients who do not respond to existing drugs. Please see http://www.fda.gov/bbs/topics/NEWS/2006/NEW01395.html
9. Hao G.-F., Yang G.-F. J. Org. Chem. 2008 28 1545 (in Chinese).
10. Ghosh A. K., Chapsal B. D., Weber I. T., Mitsuya H. Acc. Chem. Res. 2008 41 78.
11. Yang S.-L., Yu J.-G., Xu L.-Z. Acta Acad. Med. Sin. 2000 4 377 (in Chinese).
12. Dun A.-S. Sichuan Journal of Anatomy 2004 2 131 (in Chinese).
13. Ohtaka H., Freire E. Prog. Biophys. Mol. Biol. 2005 88 193.
14. Chellappan S., Kiran Kumar Reddy G. S., Ali A., Nalam M. N. L., Anjum S. G., Cao H., Kairys V., Fernandes M. X., Altman M. D., Tidor B., Rana T. M., Schiffer C. A., Gilson M. K. Chem. Biol. Drug Des. 2007 69 298.