Calcitonin gene-related peptide is a survival factor, inhibiting apoptosis in neonatal rat gubernaculum in vitro

Journal of Pediatric Surgery

Volumn 44, Issue 8, 2009, Pages 1497-1501

  Chan, Jessica J ^a,b,c   Farmer, Pam J ^a   Southwell, Bridget R ^a   Sourial, Magdy ^a   Hutson, John M ^a,b,c  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Apoptosis; Calcitonin gene related peptide; CGRP; Gubernaculum; Testicular descent

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; FLUTAMIDE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; MALE; NEWBORN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TESTIS CELL; TESTIS DESCENT;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CELL PROLIFERATION; CELLS, CULTURED; FLUTAMIDE; IN SITU NICK-END LABELING; MALE; MITOSIS; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS, NONPARAMETRIC; TESTIS;

EID: 67650931885     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2008.11.039     Document Type: Article

References (18)

1. Hutson J.M., Baker M., Terada M., et al. Hormonal control of testicular descent and the cause of cryptorchidism. Reprod Fertil Dev 6 2 (1994) 151-156
2. Tomiyama H., Sasaki Y., Huynh J., et al. Testicular descent, cryptorchidism and inguinal hernia: the Melbourne perspective. J Pediatr Urol 1 1 (2005) 11-25
3. Nightingale S.S., Western P., and Hutson J.M. The migrating gubernaculum grows like a "limb bud". J Pediatr Surg 43 2 (2008) 387-390
4. Hrabovszky Z., Di Pilla N., Yap T., et al. Role of the gubernacular bulb in cremaster muscle development of the rat. Anat Rec 267 2 (2002) 159-165
5. Fernandez-Teran M.A., Hinchliffe J.R., and Ros M.A. Birth and death of cells in limb development: a mapping study. Dev Dyn 235 (2006) 2521-2537
6. Schaeffer C., Thomassin L., Rochette L., et al. Apoptosis induced in vascular smooth muscle cells by oxidative stress is partly prevented by pretreatment with CGRP. Ann N Y Acad Sci 1010 (2003) 733-737
7. Tokudome T., Horio T., Yoshihara F., et al. Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism. Endocrinology 143 9 (2002) 3515-3521
8. Sueur S., Pesant M., Rochette L., et al. Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex. J Mol Cell Cardiol 39 6 (2005) 955-963
9. Shono T., Ramm-Anderson S., Goh D.W., et al. The effect of flutamide on testicular descent in rats by scanning electron microscopy. J Pediatr Surg 29 (1994) 839-844
10. Goh D.W., Momose Y., Middlesworth W., et al. The relationship among CGRP, androgens and gubernacular development in three animal models of cryptorchidism. J Urol 150 2 (1993) 574-576
11. Hrabovszky Z., and Hutson J.M. Capsaicin restores gubernacular contractility in TS rats. J Pediatr Surg 34 (1999) 1769-1772
12. Barthold J.S., Mahler H.R., Sziszak T.J., et al. Lack of feminization of the cremaster nucleus by prenatal flutamide administration in the rat and pig. J Urol 156 2 Pt 2 (1996) 767-771
13. Terada M., Hutson J.M., Farmer P.J., et al. The role of the genitofemoral nerve and calcitonin gene-related peptide in congenitally cryptorchid mutant TS rats. J Urol 154 2 Pt 2 (1995) 734-737
14. Shono T., and Hutson J.M. Capsaicin increases the frequency of cryptorchidism in flutamide-treated rats. J Urol 152 (1994) 763-765
15. Meier P., Finch A., and Evan G. Apoptosis in development. Nature 407 6805 (2000) 796-801
16. Aaronson I.A. Sexual Differentiation and intersexuality. In: Belman A.B., King L.R., and Kramer S.A. (Eds). Clinical Pediatric Urology. 4th ed (2002), Martin Dunitz, London 995-1059
17. King C.R., and Pernoll M.L. Sexual differentiation. Obstet Gynecol Annu 13 (1984) 1-33
18. Watson R.W.G., and Fitzpatrick J.M. Targeting apoptosis in prostate cancer: focus on caspases and inhibitors of apoptosis proteins. BJU Int 96 Suppl 2 (2005) 30-34