Outcome prediction by traditional and new markers of inflammation in patients with sepsis

Clinical Chemistry and Laboratory Medicine

Volumn 37, Issue 3, 1999, Pages 363-368

  Oberhoffer, Mathias ^a   Vogelsang, Heinz ^a   Rußwurm, Stefan ^a   Hartung, Thomas ^b   Reinhart, Konrad ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Body temperature; C reactive protein; Cytokines; Leukocyte count; Logistic regression analysis; Monocytes; Procalcitonin; Receiver operating characteristic

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; PROCALCITONIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIGEN EXPRESSION; AREA UNDER THE CURVE; BODY TEMPERATURE; CONFERENCE PAPER; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; IMMUNOASSAY; INFLAMMATION; INTENSIVE CARE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MEDIATOR; MONOCYTE; PREDICTION AND FORECASTING; PRIORITY JOURNAL; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; REGRESSION ANALYSIS; SEPSIS; THERMOMETER;

ADULT; AGED; BIOLOGICAL MARKERS; BODY TEMPERATURE; CALCITONIN; FEMALE; HLA-DR ANTIGENS; HUMANS; INFLAMMATION; INTERLEUKIN-6; LEUKOCYTE COUNT; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PROGNOSIS; PROTEIN PRECURSORS; REGRESSION ANALYSIS; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032893288     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.1999.060     Document Type: Conference Paper

References (46)

1. Rangel Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. J Am Med Assoc 1995; 273:117-23.
2. Bone RC. Important new findings in sepsis. J Am Med Assoc 1997; 278:249.
3. Wenzel RP. Anti-endotoxin monoclonal antibodies - a second look. N Engl J Med 1992; 326:1151-3.
4. Centers for Disease Control and Prevention. Increase in national hospital discharge survey rates for septicemia. Morb Motal Wkly Rep 1990; 44:31-4.
5. Pinsky MR, Vincent JL, Deviere J, Alegre M, Kahn RJ, Dupont E. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 1993; 103:565-75.
6. Marano MA, Fong Y, Moldawer LL, Wei H, Calvano SE, Tracey KJ, et al. Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality. Surg Gynecol Obstet 1990; 170:32-8.
7. Girardin E, Grau GE, Dayer JM, Roux Lombard P, Lambert PH. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 1988; 319:397-400.
8. Waage A, Halstensen A, Espevik T. Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1987; 1:355-7.
9. Martin C, Saux P, Mege JL, Perrin G, Papazian L, Gouin F. Prognostic values of serum cytokines in septic shock. Intensive Care Med 1994; 20:272-7.
10. Friedland JS, Porter JC, Daryanani S, Bland JM, Screaton NJ, Vesely MJ, et al. Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit. Crit Care Med 1996; 24:1775-81.
11. Arend WP. Inhibiting the effects of cytokines in human diseases. Adv Intern Med 1995; 40:365-94.
12. Byerley LO, Alcock NW, Starnes HF, Jr. Sepsis-induced cascade of cytokine mRNA expression: correlation with metabolic changes. Am J Physiol 1992; 262:E728-35.
13. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993:119:771-8.
14. Moscovitz H, Shofer F, Mignott H, Behrman A, Kilpatrick L . Plasma cytokine determinations in emergency department patients as a predictor of bacteremia and infectious disease severity. Crit Care Med 1994; 22:1102-7.
15. Damas P, Ledoux D, Nys M, Vrindts Y, De Groote D, Franchimont P, et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 1992; 215:356-62.
16. Hack CE, Hart M, van Schijndel RJ, Eerenberg AJ, Nuijens JH, Thijs LG, et al. Interleukin-8 in sepsis: relation to shock and inflammatory mediators. Infect Immun 1992; 60:2835-42.
17. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993; 11:165-90.
18. Cheadle WG, Mercer Jones M, Heinzelmann M, Polk HC, Jr. Sepsis and septic complications in the surgical patient: who is at risk? Shock 1996; 6 Suppl 1:S5-9.
19. Hershman MJ, Cheadle WG, Wellhausen SR, Davidson PF, Polk HC, Jr. Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg 1990; 77:204-7.
20. Hershman MJ, Cheadle WG, Kuftinec D, Polk HC, Jr. George CD. An outcome predictive score for sepsis and death following injury. Injury 1988; 19:263-6.
21. de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991; 174:915-24.
22. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine [see comments]. Chest 1992; 101:1644-55.
23. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983; 148:839-43.
24. Blackwell TS, Christman JW. Sepsis and cytokines: current status. Br J Anaesth 1996; 77:110-7.
25. van Deuren M, van der Ven Jongekrijg J, Bartelink AK, van Dalen R, Sauerwein RW, van der Meer JW. Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections. J Infect Dis 1995; 172:433-9.
26. van Dissel JT, van Langevelde P, Westendorp RG, Kwappenberg K, Frolich M. Anti-inflammatory cytokine profile and mortality in febrile patients [see comments]. Lancet 1998; 351:950-3.
27. Cheadle WG. The human leukocyte antigens and their relationship to infection. Am J Surg 1993; 165:75S-81S.
28. Hershman MJ, Appel SH, Wellhausen SR, Sonnenfeld G, Polk HC, Jr. Interferon-gamma treatment increases HLA-DR expression on monocytes in severely injured patients. Clin Exp Immunol 1989; 77:67-70.
29. Peduzzi R Shatney C, Sheagren J, Sprung C. Predictors of bacteremia and gram-negative bacteremia in patients with sepsis. The Veterans Affairs Systemic Sepsis Cooperative Study Group. Arch Intern Med 1992; 152:529-35.
30. Meisner M, Tschaikowsky K, Palmaers T, Hoefig J, Schuettler J. Procalcitonin and CRP in septic shock: inflammatory parameters with different kinetics. Intens Care Med 1996; 22:14.
31. Meisner M, Tschaikowsky K, Palmaers T, Prudlo U, Schuettler J. PCT und CRP bei Sepsis und Multiorganversagen: Korrelationen zu APACHE II und SOFA-Score? Anästhesist 1996; 45:170.
32. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993; 341:515-8.
33. Gramm HJ, Dollinger P, Beier W. Procalcitonin-A new marker of host inflammatory response. Longitudinal studies in patients with sepsis and peritonitis (translated from German). Chir Gastroenterol 1995; 11 (Supp12):51-4.
34. Eberhard OK, Haubitz M, Brunkhorst FM, Kliem V, Koch KM, Brunkhorst R. Usefulness of procalcitonin for differentiation between activity of systemic autoimmune disease (systemic lupus erythematosus/systemic antineutrophil cytoplasmic antibody-associated vasculitis) and invasive bacterial infection. Arthritis Rheum 1997; 401250-6.
35. Rau B, Steinbach G, Gansauge F, Mayer JM, Grunert A, Beger HG. The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis. Gut 1997; 41:832-40.
36. de Werra I, Jaccard C, Corradin SB, Chiolero R, Yersin B, Gallati H, et al. Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med 1997; 25:607-13.
37. Hatherill M, Jones G, Lim E, Tibby SM, Murdoch IA. Procalcitonin aids diagnosis of adrenocortical failure. Lancet 1997; 350:1749-50.
38. Staehler M, Hammer C, Meiser B, Reichart B. Procalcitonin: a new marker for differential diagnosis of acute rejection and bacterial infection in heart transplantation. Transplant Proc 1997; 29:584-5.
39. Le Moullec JM, Jullienne A, Chenais J, Lasmoles F, Guliana JM, Milhaud G, et al. The complete sequence of human preprocalcitonin. FEBS Lett 1984; 167:93-7.
40. Oberhoffer M, Stonans I, Russwurm S, Stonane E, Vogelsang H, Junker U, et al. Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis related cytokines in vitro. J Lab Chin Med 1999. In press.
41. Oberhoffer M, Vogelsang H, Jäger L, Reinhart K. Katacalcin and calcitonin immunoreactivity in different types of leukocytes indicates intracellular procalcitonin content. J Crit Care 1999. In press.
42. Dandona P, Nix D, Wilson MF, Aljada A, Love J, Assicot M, et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994; 79:1605-8.
43. Oberhoffer M, Karzai W, Meier-Hellmann A, Fassbinder J, Reinhart K. Sensitivity and specificity of various markers of inflammation for the prediction of tumor necrosis factor-α and interleukin-6 in patients with sepsis. Crit Care Med 1998. In press.
44. Nylen ES, Whang KT, Snider RH, Steinwald PM, White JC, Becker KL. Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis. Crit Care Med 1998; 26:1001-6.
45. Meissner M. PCT-Procalcitonin. A new and innovative parameter in diagnosis of infections. B.R.A.H.M.S. Diagnostics 1996.
46. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982; 143:29-36.