Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity

Molecular Systems Biology

Volumn 5, Issue , 2009, Pages

  Kitagawa, Yuichi ^a,b   Hirano, Tomoo ^a,b   Kawaguchi, Shin Ya ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; PHOSPHODIESTERASE I; 4 AMINOBUTYRIC ACID; CALCIUM; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BEHAVIORAL RESEARCH; BRAIN ELECTROPHYSIOLOGY; CELL ACTIVATION; CELL STIMULATION; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MOLECULAR MODEL; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PURKINJE CELL; SIGNAL TRANSDUCTION; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION; TISSUE CULTURE; BIOLOGICAL MODEL; COMPUTER SIMULATION; FEEDBACK SYSTEM; METABOLISM; PHYSIOLOGY; REPRODUCIBILITY; SYNAPSE;

CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; COMPUTER SIMULATION; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; FEEDBACK, BIOCHEMICAL; GAMMA-AMINOBUTYRIC ACID; MODELS, NEUROLOGICAL; NEURONAL PLASTICITY; PURKINJE CELLS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 67650838208     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2009.39     Document Type: Article

References (50)

1. 2++/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation. J Neurosci 25: 5604-5610
2. Bailey CH, Giustetto M, Huang YY, Hawkins RD, Kandel ER (2000) Is heterosynaptic modulation essential for stabilizing Hebbian plasticity and memory? Nat Rev Neurosci 1: 11-20
3. Bhalla US, Iyengar R (1999) Emergent properties of networks of biological signaling pathways. Science 283: 381-387
4. Bhalla US, Ram PT, Iyengar R (2002) MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297: 1018-1023
5. Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR (1993) Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol 13: 4760-4769
6. Brandman O, Meyer T (2008) Feedback loops shape cellular signals in space and time. Science 322: 390-395
7. Cherry JA, Davis RL (1999) Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect. J Comp Neurol 407: 287-301
8. Cooper DM, Mons N, Karpen JW (1995) Adenylyl cyclases and the interaction between calcium and cAMP signalling. Nature 374: 421-424
9. + threshold dynamics detect spike timing in cerebellar Purkinje cells. J Neurosci 25: 950-961
10. Gaiarsa JL, Caillard O, Ben-Ari Y (2002) Long-term plasticity at GABAergic and glycinergic synapses: mechanisms and functional significance. Trends Neurosci 25: 564-570
11. Hansel C, de Jeu M, Belmeguenai A, Houtman SH, Buitendijk GH, Andreev D, De Zeeuw CI, Elgersma Y (2006) αCaMKII is essential for cerebellar LTD and motor learning. Neuron 51: 835-843
12. Hansel C, Linden DJ, D'Angelo E (2001) Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum. Nat Neurosci 4: 467-475
13. 2++/calmodulin-dependent protein kinase II. J Biol Chem 264: 10884-10887
14. Hayer A, Bhalla US (2005) Molecular switches at the synapse emerge from receptor and kinase traffic. PLoS Comput Biol 1: 137-154
15. A receptors by calcium/calmodulin-dependent protein kinase II. J Neurosci 28: 7574-7584
16. Houston CM, Smart TG (2006) CaMK-II modulation of GABAA receptors expressed in HEK293, NG108-15 and rat cerebellar granule neurons. Eur J Neurosci 24: 2504-2514
17. Ito M (2001) Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 81: 1143-1195
18. Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294: 1030-1038
19. 2+ /calmodulin-dependent kinase II. Proc Natl Acad Sci USA 93: 13351-13356
20. Kano M, Rexhausen U, Dreessen J, Konnerth A (1992) Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells. Nature 356: 601-604
21. Breceptors in a Purkinje neuron. Neuron 27: 339-347
22. A receptor responsiveness in cerebellar Purkinje neurons. J Neurosci 22: 3969-3976
23. Kawaguchi S, Hirano T (2006) Integrin α3b1 suppresses long-term potentiation at inhibitory synapses on the cerebellar Purkinje neuron. Mol Cell Neurosci 31: 416-426
24. Areceptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. J Neurosci 27: 6788-6799
25. 2++ release are involved in the induction of long-term potentiation at visual cortical inhibitory synapses. J Neurosci 16: 6342-6352
26. Kuroda S, Schweighofer N, Kawato M (2001) Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation. J Neurosci 21: 5693-5702
27. Areceptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12: 1063-1076
28. Lisman J, Schulman H, Cline H (2002) The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 3: 175-190
29. Malenka RC, Nicoll RA (1999) Long-term potentiation-a decade of progress? Science 285: 1870-1874
30. Meyer T, Hanson PI, Stryer L, Schulman H (1992) Calmodulin trapping by calcium-calmodulin-dependent protein kinase. Science 256: 1199-1202
31. Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O'Dell TJ, Grant SG (1998) Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396: 433-439
32. 2+-triggered molecular switch. Cell 44: 861-870
33. Miller P, Zhabotinsky AM, Lisman JE, Wang XJ (2005) The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover. PLoS Biol 3: e107
34. Némoz G, Moueqqit M, Prigent AF, Pacheco H (1989) Isolation of similar rolipram-inhibitable cyclic-AMP-specific phosphodiesterases from rat brain and heart. Eur J Biochem 184: 511-520
35. A receptors underlies potentiation at hippocampal inhibitory synapses. Nature 395: 172-177
36. Ogasawara H, Doi T, Doya K, Kawato M (2007) Nitric oxide regulates input specificity of long-term depression and context dependence of cerebellar learning. PLoS Comput Biol 3: e179
37. Pettigrew DB, Smolen P, Baxter DA, Byrne JH (2005) Dynamic properties of regulatory motifs associated with induction of three temporal domains of memory in Aplysia. J Comput Neurosci 18: 163-181
38. Polli JW, Kincaid RL (1994) Expression of a calmodulin-dependent phosphodiesterase isoform (PDE1B1) correlates with brain regions having extensive dopaminergic innervation. J Neurosci 14: 1251-1261
39. Reed TM, Repaske DR, Snyder GL, Greengard P, Vorhees CV (2002) Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. J Neurosci 22: 5188-5197
40. 2+ /calmodulin-dependent protein kinase II inhibitor. J Neurosci 27: 5190-5199
41. Schweighofer N, Doya K, Kuroda S (2004) Cerebellar aminergic neuromodulation: towards a functional understanding. Brain Res Brain Res Rev 44: 103-116
42. Sheng M, Kim MJ (2002) Postsynaptic signaling and plasticity mechanisms. Science 298: 776-780
43. Sugiyama Y, Kawaguchi S, Hirano T (2008) mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. Eur J Neurosci 27: 884-896
44. Takeuchi T, Ohtsuki G, Yoshida T, Fukaya M, Wainai T, Yamashita M, Yamazaki Y, Mori H, Sakimura K, Kawamoto S, Watanabe M, Hirano T, Mishina M (2008) Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin. PLoS ONE 3: e2297
45. Tanaka K, Augustine GJ (2008) A positive feedback signal transduction loop determines timing of cerebellar long-term depression. Neuron 59: 608-620
46. 2+ requirements for cerebellar long-term synaptic depression: role for a postsynaptic leaky integrator. Neuron 54: 787-800
47. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ (1999) Genetic enhancement of learning and memory in mice. Nature 401: 63-69
48. Tsuruno S, Kawaguchi SY, Hirano T (2008) Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression. Neurosci Res 61: 329-332
49. Urakubo H, Honda M, Froemke RC, Kuroda S (2008) Requirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity. J Neurosci 28: 3310-3323
50. Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (1997) Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. Cell Signal 9: 519-529