To cyclize or not to cyclize: Catching enzyme evolution in the act

ACS Chemical Biology

Volumn 4, Issue 7, 2009, Pages 495-497

  Evans, Bradley S ^a   Kelleher, Neil L ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; CARBOXYLYASE; CHLORINE; CURACIN A; CYCLOPROPANE; GENE PRODUCT; HYDROLYASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; POLYKETIDE;

BIOSYNTHESIS; GENE CLUSTER; GENE SEQUENCE; GENOME; PRIORITY JOURNAL; SHORT SURVEY;

ACYL CARRIER PROTEIN; BIOLOGICAL PRODUCTS; CYANOBACTERIA; CYCLIZATION; EVOLUTION, MOLECULAR;

CYANOBACTERIA;

EID: 67650797215     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb900154b     Document Type: Short Survey

References (10)

1. Chang, Z., Sitachitta, N., Rossi, J. V., Roberts, M. A., Flatt, P. M., Jia, J., Sherman, D. H., and Gerwick, W. H. (2004) Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula, J. Nat. Prod. 67, 1356-1367 (Pubitemid 39145643)
2. Edwards, D. J., Marquez, B. L., Nogle, L. M., McPhail, K., Goeger, D. E., Roberts, M. A., and Gerwick, W. H. (2004) Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula, Chem. Biol. 11, 817-833. (Pubitemid 38836898)
3. Gu, L., Wang, B., Kulkarni, A., Geders, T. W., Grindberg, R. V., Gerwick, L., Hakansson, K., Wipf, P., Smith, J. L., Gerwick, W. H., and Sherman, D. H. (2009) Metamorphic enzyme assembly in polyketide diversification, Nature 459, 731-735.
4. Fischbach, M. A., and Walsh, C. T. (2006) Assemblyline enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms, Chem. Rev. 106, 3468-3496.
5. Calderone, C. T., Kowtoniuk, W. E., Kelleher, N. L., Walsh, C. T., and Dorrestein, P. C. (2006) Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis, Proc. Natl. Acad. Sci. U.S.A. 103, 8977-8982.
6. Gu, L., Jia, J., Liu, H., Hakansson, K., Gerwick, W. H., and Sherman, D. H. (2006) Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair, J. Am. Chem. Soc. 128, 9014-9015. (Pubitemid 44078967)
7. Jiang, H., Zirkle, R., Metz, J. G., Braun, L., Richter, L., Van Lanen, S. G., and Shen, B. (2008) The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis, J. Am. Chem. Soc. 130, 6336-6337. (Pubitemid 351706089)
8. Rahman, A. S., Hothersall, J., Crosby, J., Simpson, T. J., and Thomas, C. M. (2005) Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series, J. Biol. Chem. 280, 6399-6408. (Pubitemid 40341186)
9. Dorrestein, P. C., Bumpus, S. B., Calderone, C. T., Garneau-Tsodikova, S., Aron, Z. D., Straight, P. D., Kolter, R., Walsh, C. T., and Kelleher, N. L. (2006) Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry, Biochemistry 45, 12756-12766. (Pubitemid 44630862)
10. Dorrestein, P. C., Blackhall, J., Straight, P. D., Fischbach, M. A., Garneau-Tsodikova, S., Edwards, D. J., McLaughlin, S., Lin, M., Gerwick, W. H., Kolter, R., Walsh, C. T., and Kelleher, N. L. (2006) Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry, Biochemistry 45, 1537-1546. (Pubitemid 43222097)