메뉴 건너뛰기




Volumn 95, Issue 15, 2009, Pages 1205-1208

RAAS inhibition/blockade in patients with cardiovascular disease: Implications of recent large-scale randomised trials for clinical practice

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PLACEBO; QUINAPRIL; RAMIPRIL; TELMISARTAN; TRANDOLAPRIL; VALSARTAN;

EID: 67650732533     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2009.167080     Document Type: Editorial
Times cited : (7)

References (41)
  • 1
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • ONTARGET Investigators
    • ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008;358:1547-59.
    • (2008) N Engl J Med , vol.358 , pp. 1547-1559
  • 2
    • 62849083736 scopus 로고    scopus 로고
    • The Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: A randomised controlled trial
    • Yusuf S, Teo K, Anderson C, et al. The Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet 2008; 372:1174-83.
    • (2008) Lancet , vol.372 , pp. 1174-1183
    • Yusuf, S.1    Teo, K.2    Anderson, C.3
  • 3
    • 0034688194 scopus 로고    scopus 로고
    • The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
    • Yusuf S, Sleight P, Pogue J, et al. The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000;342:145-53.
    • (2000) N Engl J Med , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3
  • 4
    • 0042330455 scopus 로고    scopus 로고
    • EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators. Effficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: Randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
    • Fox KM. EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators. Effficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003;362:782-8.
    • (2003) Lancet , vol.362 , pp. 782-788
    • Fox, K.M.1
  • 5
    • 19644400972 scopus 로고    scopus 로고
    • Angiotensin-converting-enzyme inhibition in stable coronary artery disease
    • The Prevention of Events with Angiotensin-Converting-Enzyme (PEACE) Trial Investigators
    • The Prevention of Events with Angiotensin-Converting-Enzyme (PEACE) Trial Investigators. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med 2004;351:2058-68.
    • (2004) N Engl J Med , vol.351 , pp. 2058-2068
  • 6
    • 0032901697 scopus 로고    scopus 로고
    • QUIET Investigators. Angiotensin-converting enzyme inhibition as antiatherosclerotic therapy: No answer yet. QUinapril Ischemic Event Trial
    • Cashin-Hemphill L, Holmvang G, Chan RC, et al. QUIET Investigators. Angiotensin-converting enzyme inhibition as antiatherosclerotic therapy: no answer yet. QUinapril Ischemic Event Trial. Am J Cardiol 1999;83:43-7.
    • (1999) Am J Cardiol , vol.83 , pp. 43-47
    • Cashin-Hemphill, L.1    Holmvang, G.2    Chan, R.C.3
  • 7
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 2001;345:1667-75.
    • (2001) N Engl J Med , vol.345 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 8
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 2003;349:1893-906.
    • (2003) N Engl J Med , vol.349 , pp. 1893-1906
    • Pfeffer, M.A.1    McMurray, J.J.2    Velazquez, E.J.3
  • 9
    • 52149090673 scopus 로고    scopus 로고
    • Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: A metaanalysis
    • Reboldi G, Angeli F, Cavallini C, et al. Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a metaanalysis. J Hypertens 2008;26:1282-9.
    • (2008) J Hypertens , vol.26 , pp. 1282-1289
    • Reboldi, G.1    Angeli, F.2    Cavallini, C.3
  • 10
    • 52249116778 scopus 로고    scopus 로고
    • Telmisartan to prevent recurrent stroke and cardiovascular events
    • Yusuf S, Diener HC, Sacco RL, et al. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med 2008;359:1225-37.
    • (2008) N Engl J Med , vol.359 , pp. 1225-1237
    • Yusuf, S.1    Diener, H.C.2    Sacco, R.L.3
  • 11
    • 42049084174 scopus 로고    scopus 로고
    • ACE inhibitors in cardiovascular disease-unbeatable?
    • McMurray JJ. ACE inhibitors in cardiovascular disease-unbeatable? N Engl J Med 2008;358:1615-6.
    • (2008) N Engl J Med , vol.358 , pp. 1615-1616
    • McMurray, J.J.1
  • 12
    • 2942516035 scopus 로고    scopus 로고
    • Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin- converting enzyme inhibition in patients with heart failure
    • Cruden NL, Witherow FN, Webb DJ, et al. Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin- converting enzyme inhibition in patients with heart failure. Arterioscler Thromb Vasc Biol 2004;24:1043-8.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1043-1048
    • Cruden, N.L.1    Witherow, F.N.2    Webb, D.J.3
  • 13
    • 0030638718 scopus 로고    scopus 로고
    • Blockade of bradykinin B2 receptors prevents the increase in capillary density induced by chronic angiotensinconverting enzyme inhibitor treatment in stroke-prone spontaneously hypertensive rats
    • Gohlke P, Kuwer I, Schnell A, et al. Blockade of bradykinin B2 receptors prevents the increase in capillary density induced by chronic angiotensinconverting enzyme inhibitor treatment in stroke-prone spontaneously hypertensive rats. Hypertension 1997;29(Pt 2):478-82.
    • (1997) Hypertension , vol.29 , Issue.PART 2 , pp. 478-482
    • Gohlke, P.1    Kuwer, I.2    Schnell, A.3
  • 14
    • 0037151675 scopus 로고    scopus 로고
    • Augmentation of myocardial blood flow in hypertensive heart disease by angiotensin antagonists: A comparison of lisinopril and losartan
    • Akinboboye OO, Chou RL, Bergmann SR. Augmentation of myocardial blood flow in hypertensive heart disease by angiotensin antagonists: a comparison of lisinopril and losartan. J Am Coll Cardiol 2002;40:703-9.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 703-709
    • Akinboboye, O.O.1    Chou, R.L.2    Bergmann, S.R.3
  • 15
    • 4644297102 scopus 로고    scopus 로고
    • Myocardial perfusion during long-term angiotensinconverting enzyme inhibition or beta-blockade in patients with essential hypertension
    • Buus NH, Bottcher M, Jorgensen CG, et al. Myocardial perfusion during long-term angiotensinconverting enzyme inhibition or beta-blockade in patients with essential hypertension. Hypertension 2004;44:465-70.
    • (2004) Hypertension , vol.44 , pp. 465-470
    • Buus, N.H.1    Bottcher, M.2    Jorgensen, C.G.3
  • 16
    • 34147116836 scopus 로고    scopus 로고
    • Blood pressuredependent and independent effects of agents that inhibit the renin-angiotensin system
    • Turnbull F, Neal B, Pfeffer M, et al. Blood pressuredependent and independent effects of agents that inhibit the renin-angiotensin system. J Hypertens 2007;25:951-8.
    • (2007) J Hypertens , vol.25 , pp. 951-958
    • Turnbull, F.1    Neal, B.2    Pfeffer, M.3
  • 17
    • 58149330265 scopus 로고    scopus 로고
    • Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential
    • Krankel N, Katare RG, Siragusa M, et al. Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ Res 2008;103:1335-43.
    • (2008) Circ Res , vol.103 , pp. 1335-1343
    • Krankel, N.1    Katare, R.G.2    Siragusa, M.3
  • 18
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, double-blind, controlled trial
    • Mann JF, Schmieder RE, McQueen M, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008;372:547-53.
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.1    Schmieder, R.E.2    McQueen, M.3
  • 19
    • 49349109979 scopus 로고    scopus 로고
    • The effects of angiotensin-receptor blockers on mortality and morbidity in heart failure: A systematic review
    • Shibata MC, Tsuyuki RT, Wiebe N. The effects of angiotensin-receptor blockers on mortality and morbidity in heart failure: a systematic review. Int J Clin Pract 2008;62:1397-402.
    • (2008) Int J Clin Pract , vol.62 , pp. 1397-1402
    • Shibata, M.C.1    Tsuyuki, R.T.2    Wiebe, N.3
  • 20
    • 35348976721 scopus 로고    scopus 로고
    • Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: A quantitative review of data from randomized clinical trials
    • Phillips CO, Kashani A, Ko DK, et al. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from randomized clinical trials. Arch Intern Med 2007;167:1930-6.
    • (2007) Arch Intern Med , vol.167 , pp. 1930-1936
    • Phillips, C.O.1    Kashani, A.2    Ko, D.K.3
  • 21
    • 38049158437 scopus 로고    scopus 로고
    • Systematic review: Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension
    • Matchar DB, McCrory DC, Orlando LA, et al. Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Ann Intern Med 2008;148:16-29.
    • (2008) Ann Intern Med , vol.148 , pp. 16-29
    • Matchar, D.B.1    McCrory, D.C.2    Orlando, L.A.3
  • 22
    • 38049139424 scopus 로고    scopus 로고
    • Meta-analysis: Effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    • Kunz R, Friedrich C, Wolbers M, et al. Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease. Ann Intern Med 2008;148:30-48.
    • (2008) Ann Intern Med , vol.148 , pp. 30-48
    • Kunz, R.1    Friedrich, C.2    Wolbers, M.3
  • 23
    • 8844239987 scopus 로고    scopus 로고
    • Effect of valsartan added to background ACE inhibitor therapy in patients with heart failure: Results from Val-HeFT
    • Krum H, Carson P, Farsang C, et al. Effect of valsartan added to background ACE inhibitor therapy in patients with heart failure: results from Val-HeFT. Eur J Heart Fail 2004;6:937-45.
    • (2004) Eur J Heart Fail , vol.6 , pp. 937-945
    • Krum, H.1    Carson, P.2    Farsang, C.3
  • 24
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-convertingenzyme inhibitors: The CHARM-Added trial
    • McMurray JJ, Ostergren J, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-convertingenzyme inhibitors: the CHARM-Added trial. Lancet 2003;362:767-71.
    • (2003) Lancet , vol.362 , pp. 767-771
    • McMurray, J.J.1    Ostergren, J.2    Swedberg, K.3
  • 25
    • 33646094699 scopus 로고    scopus 로고
    • Relationship of dose of background angiotensin-converting enzyme inhibitor to the benefits of candesartan in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Added trial
    • McMurray JJ, Young JB, Dunlap ME, et al. Relationship of dose of background angiotensin-converting enzyme inhibitor to the benefits of candesartan in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Added trial. Am Heart J 2006;151:985-91.
    • (2006) Am Heart J , vol.151 , pp. 985-991
    • McMurray, J.J.1    Young, J.B.2    Dunlap, M.E.3
  • 26
    • 41149101190 scopus 로고    scopus 로고
    • Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: A systematic review and meta-analysis of randomized controlled trials
    • Lakhdar R, Al-Mallah MH, Lanfear DE. Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: a systematic review and meta-analysis of randomized controlled trials. J Card Fail 2008;14:181-8.
    • (2008) J Card Fail , vol.14 , pp. 181-188
    • Lakhdar, R.1    Al-Mallah, M.H.2    Lanfear, D.E.3
  • 27
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341:709-17.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 28
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:1309-21.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 29
    • 52449122086 scopus 로고    scopus 로고
    • Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways
    • Montezano AC, Callera GE, Yogi A, et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol 2008;28:1511-8.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1511-1518
    • Montezano, A.C.1    Callera, G.E.2    Yogi, A.3
  • 30
    • 0036898286 scopus 로고    scopus 로고
    • Hyperaldosteronism among black and white subjects with resistant hypertension
    • Calhoun D, Nishizaka M, Zaman M, et al. Hyperaldosteronism among black and white subjects with resistant hypertension. Hypertension 2002;40:892-6.
    • (2002) Hypertension , vol.40 , pp. 892-896
    • Calhoun, D.1    Nishizaka, M.2    Zaman, M.3
  • 31
    • 34047197931 scopus 로고    scopus 로고
    • Effect of spironolactone on blood pressure in subjects with resistant hypertension
    • Chapman N, Dobson J, Wilson S, et al. Effect of spironolactone on blood pressure in subjects with resistant hypertension. Hypertension 2007;49:839-45.
    • (2007) Hypertension , vol.49 , pp. 839-845
    • Chapman, N.1    Dobson, J.2    Wilson, S.3
  • 33
    • 55949112567 scopus 로고    scopus 로고
    • Serum potassium and clinical outcomes in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS)
    • Pitt B, Bakris G, Ruilope LM, et al. Serum potassium and clinical outcomes in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). Circulation 2008;118:1643-50.
    • (2008) Circulation , vol.118 , pp. 1643-1650
    • Pitt, B.1    Bakris, G.2    Ruilope, L.M.3
  • 34
    • 52049097072 scopus 로고    scopus 로고
    • Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes
    • Imanishi T, Tsujioka H, Ikejima H, et al. Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes. Hypertension 2008;52:563-72.
    • (2008) Hypertension , vol.52 , pp. 563-572
    • Imanishi, T.1    Tsujioka, H.2    Ikejima, H.3
  • 35
    • 79958249630 scopus 로고    scopus 로고
    • Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
    • McMurray J, Pitt B, Latini R, et al. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail 2008;1:17-24.
    • (2008) Circ Heart Fail , vol.1 , pp. 17-24
    • McMurray, J.1    Pitt, B.2    Latini, R.3
  • 36
    • 66749134251 scopus 로고    scopus 로고
    • Heart failure: Neurohormonal modulation [abstract]
    • Pitt B, McMurray J, Latifi R, et al. Heart failure: neurohormonal modulation [abstract]. Circulation 2007;116:2491.
    • (2007) Circulation , vol.116 , pp. 2491
    • Pitt, B.1    McMurray, J.2    Latifi, R.3
  • 37
    • 20544440652 scopus 로고    scopus 로고
    • Renin inhibition: What are the therapeutic opportunities?
    • Fisher ND, Hollenberg NK. Renin inhibition: what are the therapeutic opportunities? J Am Soc Nephrol 2005;16:592-9.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 592-599
    • Fisher, N.D.1    Hollenberg, N.K.2
  • 38
    • 40049106627 scopus 로고    scopus 로고
    • Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: A double-blind, randomised, placebo-controlled phase IIa study
    • Tissot AC, Maurer P, Nussberger J, et al. Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study. Lancet 2008;371:821-7.
    • (2008) Lancet , vol.371 , pp. 821-827
    • Tissot, A.C.1    Maurer, P.2    Nussberger, J.3
  • 39
    • 20544453256 scopus 로고    scopus 로고
    • Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage
    • Fiebeler A, Nussberger J, Shagdarsuren E, et al. Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Circulation 2005;111:3087-94.
    • (2005) Circulation , vol.111 , pp. 3087-3094
    • Fiebeler, A.1    Nussberger, J.2    Shagdarsuren, E.3
  • 40
    • 58149375072 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation: A novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
    • Kaschina E, Grzesiak A, Li J, et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 2008;118:2523-32.
    • (2008) Circulation , vol.118 , pp. 2523-2532
    • Kaschina, E.1    Grzesiak, A.2    Li, J.3
  • 41
    • 58149352445 scopus 로고    scopus 로고
    • Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart
    • Mercure C, Yogi A, Callera GE, et al. Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circ Res 2008;103:1319-26.
    • (2008) Circ Res , vol.103 , pp. 1319-1326
    • Mercure, C.1    Yogi, A.2    Callera, G.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.